RESUMO
OBJECTIVE: To study the efficacy of Reamberin in cognitive impairment in patients associated with traumatic brain injury, taking into account its effect on the parameters of neuropsychological and antioxidant status. MATERIAL AND METHODS: We examined 45 patients aged 35 to 60 years with cognitive impairment in the late period of traumatic brain injury. The patients were divided into two groups depending on the prescribed treatment. The first main group included 25 patients with cognitive impairment who received complex therapy: Reamberin against the background of standard treatment. The second control group consisted of 20 patients with cognitive impairment who received only standard therapy. In accordance with the purpose of the study, the parameters of the neuropsychological and antioxidant status were determined. RESULTS: The analysis of cognitive disorders according to the Montreal Cognitive Assessment made it possible to establish cognitive impairments in 100% of the patients included in the study in the late period of traumatic brain injury. The introduction of Reamberin to patients contributed to an improvement in work efficiency and a decrease in the amount of time required to prepare for work in relation to control (p<0.05), an increase in the volume of auditory short-term memory in dynamics from the moment of admission to the 11th day by 1.9 times (p<0.05). The evaluation of the parameters of the antioxidant status in the late period of traumatic brain injury made it possible to establish that in patients of the main group who received Reamberin as part of standard therapy, by the end of the observation (day 11), the concentration of lipid peroxidation products was lower than in the control by 13-43%, the level of ceruloplasmin and catalase activity are higher by 14 and 15%, respectively (p<0.05), which confirms the antioxidant activity of Reamberin. CONCLUSION: It was concluded that the inclusion of Reamberin in the treatment regimen for patients with cognitive impairment in the late period of traumatic brain injury should be considered clinically justified and promising.
