RESUMO
The paper considers an opportunity of using a method of design based on a scheme of a complete factor experiment to find an optimum drug composition, citing by way of example, a process of development of a diagnostic agent for liver scintigraphy on the basis of the calcium-phytate complex labelled with 99mTc taking into account biological behavior of drugs of various composition.
Assuntos
Fígado/diagnóstico por imagem , Compostos Organometálicos , Compostos de Organotecnécio , Ácido Fítico , Animais , Humanos , Cintilografia , Ratos , Software , Distribuição TecidualRESUMO
The authors present the results of an experimental study of pharmacokinetics of a new Soviet drug 99 mTc-technephyte for scintigraphy of the liver and spleen. The results of biological distribution of the agent in rat, scintigrams of the liver and spleen in rabbits and dogs have shown a high accumulation of 99 mTc-technephyte in the liver (up to 90%). The agent is prepared within one stage from a kit of reagents and 99m-sodium pertechnetate obtained using a generator.
Assuntos
Fígado/diagnóstico por imagem , Compostos Organometálicos , Compostos de Organotecnécio , Ácido Fítico , Baço/diagnóstico por imagem , Tecnécio , Animais , Cães , Cinética , Compostos Organometálicos/metabolismo , Ácido Fítico/metabolismo , Coelhos , Cintilografia , Ratos , Tecnécio/metabolismo , Distribuição TecidualRESUMO
The pharmacokinetics of 99mTc and 113mIn labeled aminopolymethyl phosphonic acids was studied in experiments on animals. Noticeable osteotropism of these compounds was shown. Scans of the rabbit and rat skeleton in health and experimental pathology 1 h after i.v. administration of these compounds were obtained making it possible to reveal the affected foci.
Assuntos
Osso e Ossos/diagnóstico por imagem , Índio , Compostos Organofosforados , Radioisótopos , Tecnécio , Animais , Osso e Ossos/metabolismo , Avaliação Pré-Clínica de Medicamentos , Feminino , Fraturas Ósseas/diagnóstico por imagem , Fraturas Ósseas/metabolismo , Índio/metabolismo , Cinética , Masculino , Neoplasias Experimentais/diagnóstico por imagem , Neoplasias Experimentais/metabolismo , Compostos Organofosforados/metabolismo , Coelhos , Radioisótopos/metabolismo , Cintilografia , Ratos , Tecnécio/metabolismo , Fatores de TempoRESUMO
113mIn-indifor pharmacokinetics was studied in 82 patients with malignant tumors (breast and lung carcinoma, reticulum cell sarcoma) in the first 2 hrs after i. v. injection. The drug redistribution in the first minutes occurred mainly between the osseous tissue and the urinary system, the value of radioactivity in the urinary bladder by the 1st hour was 50% of the injected value making it possible to visualize the kidneys. A high gradient of the drug accumulation in the osseous tissues and the adjacent organs and tissues made it possible to obtain high quality scintigrams. Radiation exposure of the skeleton was 7.0 mu Gy/MBq, that of the urinary bladder 61 mu Gy/MBq.
