1.
Bioorg Med Chem Lett
; 21(8): 2351-3, 2011 Apr 15.
Artigo
em Inglês
| MEDLINE
| ID: mdl-21421312
RESUMO
A scalable four-step synthesis of the ornithine transcarbamylase inhibitor N(5)-phosphonoacetyl-l-ornithine (PALO) is achieved through boroxazolidinone protection of ornithine. Investigations in the model organism Saccharomyces cerevisiae found that, in contrast to a previous report, PALO did not influence growth rate or expression of genes involved in arginine metabolism.