RESUMO
We present a case of angioleiomyoma, a benign angiomatous soft tissue tumor in a 52-year-old patient. We empha- size that small nodular tumors showing hypervascularity on MRI or ultrasound may be malignant and should be treated with tumor excision.
Assuntos
Angiomioma/diagnóstico , Neoplasias Musculares/diagnóstico , Músculo Esquelético/diagnóstico por imagem , Músculo Esquelético/patologia , Meios de Contraste , Diagnóstico Diferencial , Feminino , Humanos , Aumento da Imagem/métodos , Imageamento por Ressonância Magnética/métodos , Pessoa de Meia-Idade , UltrassonografiaRESUMO
Non-Hodgkin's lymphoma (NHL) is a common cause of Fever of Unknown Origin (FUO) but the presentation as a gynaecologic malignancy is exceedingly rare. To our knowledge, this represents the first report of an intravascular large B-cell lymphoma of the uterus presenting with fever of unknown origin. After a standard clinical work-up for FUO, the endometrial curettage directed by the finding of a localized fluoro-deoxyglucose Positron Emission Tomography (FDG-PET) hot spot in the pelvic area, yielded material revealing an intr avascular B-cell lymphoma. A total abdominal hysterectomy confirmed the presence of an intravascular large B-cell lymphoma in the lumina of small blood vessels of the uterus.
Assuntos
Febre de Causa Desconhecida/etiologia , Linfoma de Células B/diagnóstico por imagem , Linfoma Difuso de Grandes Células B/diagnóstico por imagem , Tomografia por Emissão de Pósitrons , Neoplasias Uterinas/diagnóstico por imagem , Útero/irrigação sanguínea , Neoplasias Vasculares/diagnóstico por imagem , Evolução Fatal , Feminino , Humanos , Imuno-Histoquímica , Linfoma de Células B/complicações , Linfoma Difuso de Grandes Células B/complicações , Linfoma Difuso de Grandes Células B/tratamento farmacológico , Linfoma Difuso de Grandes Células B/metabolismo , Pessoa de Meia-Idade , Neoplasias Uterinas/complicações , Neoplasias Uterinas/tratamento farmacológico , Neoplasias Uterinas/metabolismo , Neoplasias Vasculares/complicaçõesRESUMO
We present a case of miliary tuberculosis diagnosed 15 months after infliximab treatment despite negative screening for previous exposure to Mycobacteria on skin PPD and chest X-ray. This case shows that--although screening for TB with a skin PPD and a chest X-ray should be performed in all patients--this is not 100% effective and may be a problem in patients on concomitant immunosuppression. The clinical course of this patient further shows that in a patient treated with anti-TNF antibodies who's condition does not improve one should always be aware of the possibility of a tuberculosis infection. Even though tuberculosis is usually not rapidly fatal, the disease may show a fulminant course in immunocompromised patients.
Assuntos
Anti-Inflamatórios/efeitos adversos , Anticorpos Monoclonais/efeitos adversos , Doença de Crohn/tratamento farmacológico , Fármacos Gastrointestinais/efeitos adversos , Infecções Oportunistas/etiologia , Tuberculose Miliar/etiologia , Idoso , Antibacterianos/uso terapêutico , Anti-Inflamatórios/administração & dosagem , Anticorpos Monoclonais/administração & dosagem , Fármacos Gastrointestinais/administração & dosagem , Humanos , Infliximab , Masculino , Infecções Oportunistas/tratamento farmacológico , Tuberculose Miliar/tratamento farmacológicoRESUMO
We present a case of a newborn with Turner syndrome (TS) and a scalp skin lesion resembling cutis verticis gyrata (CVG). Several reports on CVG in TS describe the lesions and correlate it with lymphoedema frequently seen in foetuses and infants with Turner syndrome. Histological examination in this case, however, shows a congenital mucinous nevus. Possibly an abnormal amount of proteoglycans in the skin of patients with TS can clarify the occurrence of this type of skin lesion.
Assuntos
Linfedema/patologia , Dermatoses do Couro Cabeludo/patologia , Síndrome de Turner/patologia , Diagnóstico Diferencial , Feminino , Humanos , Recém-Nascido , Dermatoses do Couro Cabeludo/etiologia , Síndrome de Turner/complicações , Síndrome de Turner/genéticaRESUMO
Uterine adenosarcoma (UAS) is microscopically characterized by a biphasic growth pattern. By definition, the epithelial component is benign, whereas the stromal component typically has the appearance of a low-grade sarcoma, usually an endometrial stromal sarcoma. CD10 acts by reducing cellular response to peptide hormones and is currently regarded as a specific marker for endometrial stromal tumors. In this international multicenter study, we further explored CD10 immunoreactivity in 30 UASs. We encountered CD10 positivity of the sarcomatous component in 18/20 (90%) of UASs, in five of eight (63%) of UASs with sarcomatous overgrowth as well as in both cases of recurrent UAS. The epithelial component stained negative in all cases. These findings suggest that CD10 can be used to differentiate UAS from cellular leiomyoma, or in case endometrial stromal cells exhibit muscle differentiation. Furthermore, CD10 positivity in recurrent UAS might guide the pathologist toward an endometrial stromal origin.
