1.
Bioorg Med Chem
; 11(15): 3229-36, 2003 Jul 31.
Artigo
em Inglês
| MEDLINE
| ID: mdl-12837532
RESUMO
Four potential S-adenosyl-L-homocysteine hydrolase inhibitors were prepared and tested against purified recombinant rat liver enzyme. Preliminary studies indicate that three of these compounds, 1, 2, and 4, caused time-dependent inactivation of S-adenosyl-L-homocysteine hydrolase but showed a biphasic nature. Compound 3 was found to be a rapid equilibrium inhibitor of this enzyme.
Assuntos
Adenosil-Homocisteinase/antagonistas & inibidores , Inibidores Enzimáticos/síntese química , Inibidores Enzimáticos/farmacocinética , Adenosil-Homocisteinase/metabolismo , Animais , Fígado/metabolismo , Ratos , Fatores de Tempo
2.
Bioorg Med Chem Lett
; 12(3): 457-60, 2002 Feb 11.
Artigo
em Inglês
| MEDLINE
| ID: mdl-11814819
RESUMO
A phosphonic acid analogue of S-adenosyl-L-homocysteine was prepared by a novel method and the epimeric mixture separated. Preliminary studies indicate that each epimer causes time-dependent inactivation of S-adenosyl-L-homocysteine hydrolase, however each presented distinct kinetic characteristics.