1.
Bioorg Med Chem Lett
; 20(10): 3039-42, 2010 May 15.
Artigo
em Inglês
| MEDLINE
| ID: mdl-20403696
RESUMO
A series of C-2 pyrroloquinoline analogs designed to improve aqueous solubility were examined for herpesvirus polymerase and antiviral activity. Several analogs were identified that maintained the antiviral activity of the previous development candidate against HCMV, HSV-1 and VZV, but with significantly improved aqueous solubility.
Assuntos
Antivirais/química , Herpesviridae/enzimologia , Inibidores da Síntese de Ácido Nucleico , Pirróis/química , Quinolinas/química , Antivirais/síntese química , Antivirais/farmacologia , Citomegalovirus/efeitos dos fármacos , DNA Polimerase Dirigida por DNA/metabolismo , Herpesvirus Humano 1/efeitos dos fármacos , Herpesvirus Humano 3/efeitos dos fármacos , Humanos , Pirróis/síntese química , Pirróis/farmacologia , Quinolinas/síntese química , Quinolinas/farmacologia , Solubilidade , Relação Estrutura-Atividade
2.
Bioorg Med Chem Lett
; 20(6): 1994-2000, 2010 Mar 15.
Artigo
em Inglês
| MEDLINE
| ID: mdl-20167488
RESUMO
Discovery efforts were focused on identifying a non-nucleoside antiviral for treating infections caused by human cytomegalovirus (HCMV) with equal or better potency and diminished toxicity compared to current therapeutics. This Letter describes the HCMV DNA polymerase inhibition and in vitro antiviral activity of various 2-aryl-2-hydroxy ethylamine substituted 1H,7H-pyrido[1,2,3-de]quinoxaline-6-carboxamides.