Current use of an intrauterine device and risk of tubal pregnancy.

Using data from a population-based, case-control study, we assessed risk of tubal pregnancy associated with use of an intrauterine device (IUD) at the time of conception. Cases were 249 members of Group Health Cooperative of Puget Sound who experienced a tubal pregnancy between 1981 and 1986. Controls were 831 members at risk of ectopic pregnancy who were similar to cases with respect to age and county of residence, but otherwise selected at random. Risk of tubal pregnancy associated with current IUD use was compared separately to that among users of various other (or no) contraceptive methods. Tubal pregnancy was more likely to occur among IUD users than among women using oral contraceptives [relative risk (RR) = 3.8, 95% confidence interval (CI) = 1.5-9.9] or barrier methods (RR = 3.6, 95% CI = 1.6-8.1), or, to a lesser extent, among women who had been surgically sterilized (RR = 1.6, 95% CI = 0.8-3.5). In contrast, IUD users were much less likely to experience a tubal pregnancy (RR = 0.2, 95% CI = 0.1-0.4) than were women who were currently not contracepting. For most women, the decision to use an IUD occurs within the context of choosing among various contraceptive methods. Our results indicate that, for these women, the decision to use an IUD results in increased risk of ectopic pregnancy while the device is in use.

PIP: In King County, Washington, health workers interviewed 249 members of Group Health Cooperative of Puget Sound who had had an ectopic pregnancy between October 1981 and September 1986 and 831 randomly selected, age- and county-matched controls who were at risk of ectopic pregnancy. Researchers wanted to examine the risk of ectopic pregnancy associated with IUD use at time of conception. The Copper 7 IUD was the most common IUD used (66.7% of cases and 65% of controls). Cases were more likely to have a positive titer for C. trachomatis than controls (33.8% vs. 17.6%). In comparison with users of oral contraceptives, barrier methods, and tubal sterilization, IUD use increased the risk of ectopic pregnancy (relative risk [RR] = 3.8, 3.6, and 1.6, respectively). On other hand, IUD users were less likely to experience ectopic pregnancy than women not using any contraception or using other contraceptive methods (RR = 0.2 and 0.6, respectively). All the aforementioned results did not change when the researchers only considered women using the Copper 7 IUD. The risk of ectopic pregnancy fell with increasing duration of IUD use among current users, but the numbers of women were small (e.g., odds ratio for 36-72 months = 0.6 and for 72 months = 0.4). These findings suggest that, for women in the midst of choosing a contraceptive, the risk of ectopic pregnancy is high when an IUD is in situ.

Past use of an intrauterine device and risk of tubal pregnancy.

We assessed risk of tubal pregnancy associated with past use of an intrauterine device (IUD). Cases were 256 members of Group Health Cooperative of Puget Sound who experienced a tubal pregnancy between 1981 and 1986. Controls were 666 female members of the Cooperative at risk of ectopic pregnancy who were similar to cases with respect to age and county of residence, but otherwise selected at random. The presence of antibody to Chlamydia trachomatis was assessed in a sample of 134 cases and 182 controls. Women who had previously used an IUD for 3 or more years were more than twice as likely as women who had never used an IUD to have a tubal pregnancy (adjusted relative risk = 2.5, 95% confidence interval = 1.5-4.3). Among these long-term users of an IUD, risk of tubal pregnancy remained elevated for many years after the device was removed. Also, among long-term users, women known to have more than one IUD insertion were no more likely than women with one known insertion to develop a tubal pregnancy. When we restricted our analyses to women who used only copper-containing devices, the results were nearly identical. We conclude that extended past use of an IUD, including use of a copper device, increases the risk of tubal pregnancy.

PIP: In King County, Washington, health workers interviewed 256 members of the Group Health Cooperative of Puget Sound who had had an ectopic pregnancy between October 1981 and September 1986 and 666 randomly selected, age and country matched controls who were at risk of ectopic pregnancy. Researchers wanted to examine the risk of ectopic pregnancy associated with past use of an IUD, particularly a copper releasing IUD They tested for Chlamydia trachomatis antibody in 134 cases and 182 controls. Cases were more likely to have a positive titer for C. trachomatis than controls (42.5% vs. 18.1%). The risk of ectopic pregnancy rose with increasing duration of past IUD use (e.g., odds ratio for past IUD use of 36 or more months was 2.5). The risk was the same when the researchers only considered past use of copper releasing IUDs. Further, the risk remained elevated for at least 7 years after stopping IUD use, including copper IUDs. Women with no evidence of chlamydial infection experienced an elevated risk of ectopic pregnancy with increasing duration of past IUD use (adjusted relative risk at 36 or more months was 3.4 for all IUD users and 5.5 for copper IUD users), suggesting that events other than chlamydial salpingitis damage tubes in IUD users. Among women who used IUDs for at least 36 months in the past, women who continuously used the same IUD were just likely to have an ectopic pregnancy as were those with more than one IUD insertion. These results indicate that longterm, past use of an IUD, including a copper IUD, elevates the risk of ectopic pregnancy.

Current cigarette smoking and risk of acute pelvic inflammatory disease.

OBJECTIVES: Further information is needed on modifiable factors associated with the occurrence of acute pelvic inflammatory disease (PID). Cigarette smoking has been implicated as a risk factor for PID sequelae, but the association between smoking and PID has yet to be fully examined. METHODS: We conducted a population-based case-control study to evaluate smoking as a risk factor for acute PID. The case patients (n = 131) were women health maintenance organization (HMO) enrollees between the ages of 18 and 40 years who were treated for a first episode of PID. The control patients (n = 294) were randomly selected from the HMO enrollment files. RESULTS: Relative to never smokers, current smokers were at increased risk of PID. Women who smoked 10 or more cigarettes per day had a higher risk than did those who smoked less. Available data indicate that smoking status is not serving as a marker for uncontrolled confounding by lifestyle factors. CONCLUSIONS: Our study results suggest that smoking represents a modifiable risk factor for acute PID.

Tubal sterilization and subsequent ectopic pregnancy. A case-control study.

OBJECTIVE: To assess the relative risk of ectopic pregnancy associated with postpartum or interval tubal sterilization. DESIGN: Case-control study using a comparison group of women of reproductive age at risk of pregnancy. SETTING: Group Health Cooperative of Puget Sound, a health maintenance organization based in Seattle, Wash. organization based in Seattle, Wash. PARTICIPANTS: Cases were 249 enrollees diagnosed as having an ectopic pregnancy between October 1, 1981, and September 30, 1986. Controls were 835 randomly selected enrollees matched to cases on age and county of residence. MEASUREMENTS: Information on interval sterilization history was obtained from interviews, examination of medical records, automated hospitalization files and a previously validated algorithm. A logistic regression model was used to estimate relative risks (RRs) for sterilized women compared with women using other types of or no contraception at the reference date. RESULTS: Controlling for age, county, race, smoking, income, gravidity, and prior use of a Dalkon Shield intrauterine device, the risk of ectopic pregnancy in women who had undergone interval sterilization was 3.7 (95% confidence interval [CI], 1.7 to 8.0) times that of women currently using oral contraception and 2.8 (95% CI, 1.5 to 5.5) times that of women currently using barrier contraceptive methods. Use of interval sterilization was associated with a risk of ectopic pregnancy similar to that of women using intrauterine devices (RR, 0.8; 95% CI, 0.4 to 1.7) and a risk lower than that of women who were not using contraception (RR, 0.2; 95% CI, 0.1 to 0.3). The corresponding RRs associated with postpartum sterilization were lower: 1.2 (95% CI, 0.3 to 3.9), 0.9 (95% CI, 0.3 to 2.8), 0.3 (95% CI, 0.1 to 0.8), and 0.1 (95% CI, 0.0 to 0.2), respectively. CONCLUSION: Tubal sterilization provides some protection against extrauterine as well as intrauterine pregnancy. It is likely that postpartum sterilization can be a safe alternative to all types of temporary contraception in terms of risk of ectopic pregnancy, while some types of interval sterilization may lead to an increased risk, in comparison with use of oral contraceptives or barrier methods.

Prior condom use and the risk of tubal pregnancy.

The relationship between prior condom use and tubal pregnancy was assessed in a population-based case-control study at Group Health Cooperative of Puget Sound during 1981-86. We interviewed 227 women with a tubal pregnancy who had no clinical indication of infertility and no history of sterilization and 674 similarly defined controls who were matched to the cases on age and county of residence. A history of condom use for more than one year was associated with a decreased risk of subsequent tubal pregnancy (RR = 0.74, 95% CI = 0.44, 1.26) adjusted for the effects of age, current use of contraceptive methods, educational level, and age at first intercourse. The effect was more pronounced when condoms had been used during five-year periods with more than one partner (RR = 0.38, 95% CI = 0.15, 1.0) than during five-year periods with one partner (RR = 0.89, 95% CI = 0.45, 1.76). Condom use for less than one year was unrelated to risk of ectopic pregnancy. Since the use of condoms offers protection against sexually transmitted diseases, one or more of which are likely to be causally related to tubal pregnancy, the observed negative association plausibly represents a protective influence of long-term condom use on the occurrence of tubal pregnancy.

Effect of a clinical pharmacist program on the cost of hypertension treatment in an HMO family practice clinic.

This study evaluated the impact of a clinical pharmacy service on the cost of antihypertensive drug therapy in an HMO family practice clinic. The service was provided to five family practice physicians. Pharmacists identified hypertensive patients prior to their regularly scheduled office visits from April through June 1986. Patient's medical records and computerized drug files were reviewed, and written recommendations for drug therapy changes were placed in patients' medical record by the pharmacists. When appropriate, pharmacists alerted prescribers to lower cost alternatives. A matched control group of physicians was selected. Hypertensive patients were identified retrospectively in the control group. We found that the cost of antihypertensive drug therapy was significantly higher for study physicians' patients when compared with control physicians' patients in the period prior to implementing the service. The difference between the two groups was not significant after six months. Clinical pharmacist intervention decreased the average cost of antihypertensive treatment from 33.4 to 27.2 cents per day.

Record linkage studies for postmarketing drug surveillance: data quality and validity considerations.

Large automated databases are the source of information for many record linkage studies, including postmarketing drug surveillance. Despite this reliance on prerecorded data, there have been few attempts to assess data quality and validity. This article presents some of the basic data quality and validity issues in applying record linkage methods to postmarketing surveillance. Studies based on prerecorded data, as in most record linkage studies, have all the inherent problems of the data from which they are derived. Sources of threats to the validity of record linkage studies include the completeness of data, the ability to accurately identify and follow the records of individuals through time and place, and the validity of data. This article also describes techniques for evaluating data quality and validity. Postmarketing surveillance could benefit from more attention to identifying and solving the problems associated with record linkage studies.

Pharmacy and health planning: a national survey of health planners.

The extent of pharmacy involvement in area health planning, and the perception of health planners on pharmacy and drug-related issues, were assessed. Health Systems Agencies (HSAs) (135, or 66%) and State Health Planning and Development Agencies (SHPDAs) (25, or 45%) responded to a 34-item mail questionnaire on pharmacy planning issues. Pharmacists were involved in developing health plans in 39% of the HSAs and 18% of the SHPDAs. Pharmaceutical services were mentioned in 50% of the local and 58% of the state plans. Thirty-two percent of the HSAs and 42% of the SHPDAs believed there was a poor distribution of pharmacies in health service areas. The respondents also answered questions on the need for pharmaceutical services in given areas and among special populations, drug reimbursement procedures, and the kinds of data health planners need when planning pharmaceutical services. Numerous respondents noted that increased participation by pharmacy groups in health planning would be desirable and welcomed.