RESUMO
An optimized therapeutic rehabilitation program involved 393 patients with fractured long bones (humeral, radial/ulnar, femoral, crural) admitted to the Orthopedic Department of the Stavropol Regional Children's Clinical Hospital and the Rehabilitation Centre for Handicapped Children and Adolescents. Rehabilitation was performed in three consecutive stages, viz. immobilization, functional recovery and training. The proposed approach ensured rather fast functional recovery of the affected extremity even in cases with compound fractures. The rehabilitation program included polyenzyme therapy with wobenzym during 3-4 weeks after injury or surgical repositioning of bone fragments. Pain and oedema syndromes resolved twice as fast as after traditional treatment. The use of this program permitted to avoid development of contracture and disturbances of locomotary activity; moreover, it improved the quality of life in children with fractures of long tubular bones.
Assuntos
Fraturas do Fêmur/reabilitação , Fixação de Fratura/métodos , Fraturas do Úmero/reabilitação , Fraturas da Tíbia/reabilitação , Fraturas da Ulna/reabilitação , Criança , Combinação de Medicamentos , Fraturas do Fêmur/tratamento farmacológico , Fraturas do Fêmur/cirurgia , Humanos , Fraturas do Úmero/tratamento farmacológico , Fraturas do Úmero/cirurgia , Hidrolases/administração & dosagem , Hidrolases/uso terapêutico , Qualidade de Vida , Recuperação de Função Fisiológica , Rutina/administração & dosagem , Rutina/uso terapêutico , Fraturas da Tíbia/tratamento farmacológico , Fraturas da Tíbia/cirurgia , Resultado do Tratamento , Fraturas da Ulna/tratamento farmacológico , Fraturas da Ulna/cirurgiaRESUMO
The effectiveness and safety of treatment with vobenzyme supplemented to the standard antibiotic therapy have been compared in 60 patients. Addition of vobenzyme to the standard antibiotic therapy significantly reduces the number and degree of respiratory symptoms has a pronounced effect on the activity of inflammation, leads to a more complete reversal of pulmonary parenchymatous infiltration on a roentgenogram, contributes to the achievement of the maximum efficiency of treatment, and substantially diminishes residual respiratory symptoms of pneumonia economically expediently and safety at a late follow-up.
Assuntos
Infecções Comunitárias Adquiridas/tratamento farmacológico , Terapia Enzimática , Pneumonia Bacteriana/tratamento farmacológico , Adolescente , Adulto , Idoso , Antibacterianos/uso terapêutico , Infecções Comunitárias Adquiridas/diagnóstico por imagem , Relação Dose-Resposta a Droga , Quimioterapia Combinada , Enzimas/administração & dosagem , Feminino , Seguimentos , Humanos , Masculino , Pessoa de Meia-Idade , Pneumonia Bacteriana/diagnóstico por imagem , Radiografia Torácica , Resultado do Tratamento , Adulto JovemRESUMO
The effect of the enzyme complex from Vobenzin on transfer of plasmid genes in biofilms of gramnegative bacteria was studied. The extracellular matrix of the bacterial biofilms was shown to contain extracellular DNA carrying the antibiotic resistance markers. The action of the enzyme complex resulted in lower frequency of the antibiotic resistance genes transfer in mixed bacterial biofilms.