1.
Org Lett
; 17(19): 4694-7, 2015 Oct 02.
Artigo
em Inglês
| MEDLINE
| ID: mdl-26367818
RESUMO
The A-D fragment of gambieric acids A and C has been synthesized using an asymmetric Tsuji-Trost allylation reaction to couple the two key segments. The A ring fragment has been prepared by a short and highly efficient route involving diastereoselective Lewis acid mediated alkylation of an acetal. Iterative ring-closing metathesis reactions have been used to construct cyclic ethers and assemble the tricyclic B-D fragment.