Assuntos
Procedimentos Cirúrgicos Cardíacos/métodos , Matriz Extracelular/transplante , Migração de Corpo Estranho/patologia , Cardiopatias Congênitas/cirurgia , Mucosa Intestinal/transplante , Intestino Delgado/transplante , Adulto , Animais , Biópsia , Procedimentos Cirúrgicos Cardíacos/efeitos adversos , Criança , Pré-Escolar , Matriz Extracelular/patologia , Feminino , Migração de Corpo Estranho/etiologia , Migração de Corpo Estranho/cirurgia , Xenoenxertos , Humanos , Recém-Nascido , Mucosa Intestinal/patologia , Intestino Delgado/patologia , Masculino , Reoperação , Estudos Retrospectivos , Sus scrofa , Fatores de Tempo , Falha de TratamentoRESUMO
AIM: Bone osteoradionecrosis is a serious complication of radiation treatment. Current treatment approaches are not curative and treatment response is often poor leading to high social and healthcare costs. CASE REPORT: We report on the first case of osteoradionecrosis with successful restitutio ab integro by repeated administration of platelet gel (PLT-gel) and surgery in a critically ill patient. The administration of PLT-gel during a severe septic episode helped regeneration of bone and soft tissues, shortening the hospital stay of the patient. It was also noted that following applications of PLT-gel, both the use of morphine and the numbers of infective episodes were reduced. CONCLUSION: Additional studies are needed to confirm the promising effect of PLT-gel for the treatment of osteoradionecrosis.