RESUMO
The enantiomerically pure chlorins 19 and 21 were synthesised from tripyrrolic nickel complex rac-17 and pyrrole building blocks 12 and 16. The pyrroles are annelated with norbornane moieties which contain the chiral information as well as two different functionalities. The functional groups, namely a carboxylic acid ester and a carbonitrile group, of chlorin 21 finally allowed the formation of an amino acid functionality at the periphery of the macrotetracycle. By using principles of peptide chemistry, the two chlorin subunits were joined to form the peptide-linked chlorin-chlorin dyad 24, which mimics the molecular parts of the natural photosynthetic reaction centre.
Assuntos
Modelos Biológicos , Peptídeos/síntese química , Complexo de Proteínas do Centro de Reação Fotossintética/fisiologia , Porfirinas/síntese químicaRESUMO
A systematic study of basis set superposition error (BSSE) behavior in H(3)C-H[ellipsis (horizontal)][NO] complexes for both -H...N- and -H...O- orientations were carried out using MP2 and density-functional theory with Pople's [6-31G(d,p),6-311++G(nd,nd), where n=1,2,3, and 6-311++G(3df,3pd)] and Dunning's augmented correlation consistent basis sets [aug-cc-pVXZ (X=D and T)]. Corrected and uncorrected counterpoise potential-energy surfaces (PESs) were explored and differences obtained between them indicate that reliable optimizations of these molecular interactions must be carried out in a PES free of BSSE, even in the case of large basis sets and popularly used functionals such as B3LYP. Although all basis used could be always considered within a margin of approximation for representing molecular orbitals and show important values of BSSE, 6-311++G(2d,2p) basis set shows the best results in uncorrected PES with respect to the corrected ones. B3LYP functional produces erratic results: complexes appear repulsive and the intermolecular distances are always large, evidencing the lack of a correct dispersive forces treatment in the original parameterization. According to the MP2 results, the -H...N- interactions appear as slightly more stable than those of the -H...O- orientation.
RESUMO
[1,2,5]Thiadiazolo[3,4-c][1,2,5]thiadiazole (1) is synthesized in 62% yield by fluoride ion-induced condensation of 3,4-difluoro-1,2,5-thiadiazole with (Me(3)SiN=)(2)S. The reversible electrochemical reduction of 1 leads to the long-lived [1,2,5]thiadiazolo[3,4-c][1,2,5]thiadiazolidyl radical anion (2) and further to the dianion (3). The radical anion 2 is also obtained by the chemical reduction of the precursor 1 with t-BuOK in MeCN. The radical anion 2 is characterized by ESR spectroscopy in solution and in the crystalline state. The stable salts [K(18-crown-6)][2] and [K(18-crown-6)][2].MeCN (8 and 9, respectively) are isolated from the spontaneous decomposition of the [K(18-crown-6)][PhXNSN] (6, X = S; 7, X = Se) salts in MeCN solution followed by XRD characterization. The radical anion 2 acts as a bridging ligand in 8 and as chelating ligand in 9. The structural changes observed by XRD in going from 1 to 2 are explained by means of DFT/(U)B3LYP/6-311+G calculations.
RESUMO
In the OSF(4)/Me(2)NSiMe(3) system besides the long known Me(2)NS(O)F(3) only the trisubstituted derivative is isolated as (Me(2)N)(3)SO(+)Me(3)SiF(2)(-) (3). Similar to (Me(2)N)(3)S(+)Me(3)SiF(2)(-) compound 3 is an excellent fluoride ion donor. With AsF(5) and HF the corresponding hexafluoroarsenate (Me(2)N)(3)SO(+)AsF(6)(-) (4) and the hydrogen bifluoride (Me(2)N)(3)SO(+)HF(2)(-) (5) are formed in almost quantitative yield. X-ray structure determinations of 3-5 surprisingly showed two different types of structures for the cation. In 3 and 5 this cation has C(3) symmetry, while in the hexafluoroarsenate 4 a (Me(2)N)(3)S(+)-like structure with C(s)() symmetry is determined. The experimental results for (Me(2)N)(3)SO(+) and (Me(2)N)(3)S(+) are compared with theoretical calculations for these cations and their isoelectronic neutral counterparts, the phosphorus amides (Me(2)N)(3)PO and (Me(2)N)(3)P, respectively.