RESUMO
Content of amino acids in the blood serum using ion-exchange chromatography and a quantitative crystalloscopic "closed drop" method was measured in 105 patients with multiple sclerosis of different severity. The relation between the dynamics of content of glutamic, asparagine acids and glycine and the disease severity was determined. The highest level of glutamic acid was found in the patients with severe disease course. The dynamics of quantitative changes in the amino acid content was accompanied by the disturbance of blood serum structuration and appearance of selective micromorphotypes. The positive correlation between the severity of motor and coordination disorders and the increase in levels of glutamic acid and glycine in the severe cases was detected.
Assuntos
Ácido Aspártico/sangue , Ácido Glutâmico/sangue , Glicina/sangue , Esclerose Múltipla/sangue , Esclerose Múltipla/fisiopatologia , Adulto , Cromatografia por Troca Iônica , Feminino , Humanos , Masculino , Índice de Gravidade de DoençaRESUMO
Thirteen antibiotics of red, rose, yellow and violet color, which are synthesized by the soil Streptomycetes on the complete corn-bean medium have been isolated and purified by means of thin layer chromatography. Antibiotic activity of the obtained compounds has been determined against a series of gram-positive and gram-negative microorganisms, and also yeasts. The maxima of absorption of antibiotics in visible and UV-light were established. The preliminary results are obtained about the presence of sugar component in the structure of molecules, as well as the indicator properties of the red-color antibiotics. The assumption was proposed about the affinity of some antibiotics for anthracyclines and ansamycines.