Atypical clinical presentation of pathologically proven Parkinson's disease: The role of Parkinson's disease related metabolic pattern.

Regional changes in brain metabolism upgraded with measurements of specific metabolic brain patterns and automated diagnostic algorithms can help to differentiate among neurodegenerative parkinsonisms, but with few reports on pathological confirmation. Here we describe a parkinsonian patient with atypical presentation and 18F-FDG-PET imaging consistent with idiopathic Parkinson's disease. The latter was confirmed at the pathohistological examination.

A case of haemangioblastoma of the fourth ventricle presenting with depression.

Haemangioblastoma (Hab) is a rare, benign and slow-growing tumour of uncertain histiogenesis. It constitutes roughly 1% to 2% of all intracranial tumours and most commonly arises in the posterior cranial fossa: more than 80% of Habs are located in the cerebellar hemispheres, the remaining cases lie in the vermis, brainstem and spinal cord. In about 20% of the cases Habs are associated with the hereditary disorder known as von Hippel-Lindau disease (VHL). Usually, Hab presents with symptoms of increased intracranial pressure and focal neurological symptoms, which depend on the tumour location. Here, a case of Hab localised in the fourth ventricle that manifested with an unusual clinical picture featuring predominant psychiatric symptoms is described; the condition went unrecognised until the patient's death.