[Clinical effect of chitosan in bacterial vaginosis therapy].

AIM: Determination of antibacterial activity of acid-soluble chitosan in bacterial vaginosis therapy in women of reproductive age and comparison of therapy results of traditional scheme and local administration of acid-soluble chitosan. MATERIALS AND METHODS: Vaginal microflora of 76 gynecologic and obstetrical female patients (18-43 years of age) with bacterial vaginosis diagnosis was examined by using bacteriological method. Control group consisted of 30 practically healthy women. Sensitivity of 145 bacteria strains from 14 genera to 2% acid-soluble chitosan solution (200-250 kDa molecularweight) was determined by using agar diffusion method. RESULTS: During bacterial vaginosis members of the Gardnerella, Mobiluncus and Bacteroides genera dominated with a background reduction of lactobacilli quantity. An increase of population level of Staphylococcus, Enterococcus, Prevotella, Porphyromonas, Peptostreptococcus genera members, and Candida species was also observed. All the microorganisms were sensitive to 2% chitosan solution. Mycoplasma and Ureaplasma spp. were sensitive to chitosan in 82% of cases. Administration of chitosan in local therapy of vaginosis resulted in suppression of opportunistic microflora and clinical effect with a lack of adverse effects. CONCLUSION: Local administration of chitosan is perspective against bacterial vaginosis.

[The preclinical diagnosis of threatened abortion and late gestosis in pregnant women with normal body weight and obesity]. / Doklinicheskaia diagnostika ugrozy nevynashivaniia beremennosti i pozdnikh gestozov u beremennykh s normal'noi massoi tela i ozhireniem.

Measurements of blood serum phosphatidyl inosites in pregnant women with normal body mass and with obesity in whom pregnancy ran normal or pathological course showed that phosphatidyl inositol levels increased 2-3-fold in case of threatened miscarriage and decreased 2-3-fold if symptoms of late gestosis appeared (an abnormal gain in body mass) as compared to their levels in women with an uneventful course of pregnancy. Phosphatidyl inositol levels were higher in obese women that in those with normal body mass, no matter what the pregnancy course was.