[Alcohol dehydrogenase polymorphism and the genotypic adaptation of D. melanogaster to the action of selective factors]. / Polimorfizm alkogol'degidrogenazy i genotipicheskaia adaptatsiia D. melanogaster k deistviiu selektivnykh faktorov.

Analysis of experimental populations of Drosophila has shown different selective value of S- and F-alleles of Adh locus under selection for delayed aging, resistance to elevated temperature and ethanol. Selection for delayed aging and resistance to hyperthermia was accompanied by an increase of Adhs frequency in populations and genotypic adaptation to ethanol- by an increase of AdhF frequency.

[Gene-enzyme system of alcohol dehydrogenase and adaptation of Drosophila to increased temperature]. / Gen-énzimnaia sistema alkogol'degidrogenazy i adaptatsiia drosofily k povyshennoi temperature.

Properties and allelic ADH (alcohol dehydrogenase) control in Drosophila melanogaster were studied upon flies' cultivation under conditions of hypotherm of different intensity and duration. Lines homozygotic for F allele (vg) and S allele (cn) of the Adh gene as well as genetically enriched experimental cn' and vg' populations containing a small number of AdhF/AdhS heterozygotes at the initial stage were used. It was found out that physiological adaptation of the species to momentary influence of elevated temperature is accompanied by modification of physical properties of ADH-F according to ADH-S. Constant influence (during the life span of 25 generations) of elevated temperature on the population changes its genetic structure, due to selective advantages of the S allele of Adh under these conditions.

[Effect of 5,6-hydroxytryptamine and various light schedules on the hypothalamo-hypophyseo-gonadal system of the female rat]. / Vliianie 5,6-oksitriptamina i raznykh svetovykh rezhimov na gipotalamo-gipofizarno-gonadnuiu sistemu samok krys.

Hypothalamic luliberin and plasma lutropin concentration were studied under normal light-darkness cycle or under constant illumination in rats. Some of them were injected with 5,6-dihydroxytryptamine (5,6-HTA) into the lateral brain ventricle. Constant illumination led to a persistent oestrus with a significant drop in plasma lutropin and a decrease in hypothalamic luliberin. Destruction of serotoninergic terminals with 5,6-HTA resulted in an opposite effect and prevented to some extent inhibiting influence of constant illumination. Luliberin synthesis and secretion seem to be suppressed by serotoninergic nerve terminals on the luliberin producing cells as well as by serotonin reaching the hypothalamus from the pineal gland.

[Effect of 6-hydroxydopamine and 5,6-Dihydroxytryptophan on the luliberin and luteinizing hormone levels in female rats under constant illumination]. / Vliianie 6-oksidofamina i 5,6-oksitriptofana na uroven' liuliberina i liuteiniziruiushchego gormona u samok krys pri postoiannom osveshchenii.

Administration of 5,6-oxytryptophan to female rats' 3rd cerebral ventricle, as opposed to 6-oxydopamine, prevents the decrease in the luteinizing hormone contents in the blood occurring under constant illumination. Administration of 6-oxydopamine against the background of desmethylimipramine caused a significant increase of the luliberine contents in the anterior hypothalamus while preserving its normal level in the medio-basal portion.

[Comparative characteristics of the immunologic structure of children's collectives as regards scarlatina in different climatic zones]. / Sravnitel'naia kharakteristika immunologicheskoi struktury detskikh kollektivov v otnoshenii skarlatiny v raznykh klimaticheskikh zonakh

An immunological study (in respect to scarlet fever) of children in children's collective bodies was conducted in 1971-1972 simultaneously in two towns-Ashkhabad and Petrozavodsk located in the contrast climatic zones. Results of Dick's test and passive hemagglutination test indicated no significant differences in the level and intensity of antitoxic immunity in children of both cities; only during the autumn period, corresponding to the seasonal increase in the incidence of scarler fever in Ashkabad, the number of immune children in this town proved to be greater than in Petrozavodsk, this being connected with a more active process of "mute" immunization. At the same time differences were revealed in the level and dynamics of antibodies to the leading types of M-antigens of hemolytic streptococci. Consequently, a higher immunological reactivity of the organism in children in Ashkhabad (promoting rapid formation of both the antitoxic and the antimicrobial immunity and limiting of the spread of marked scarlet fever affections) underlied the differences in the level of scarlet fever morbidity in different climatic zones.

[Correlated interrelationships between the concentrations of chorionic gonadotropin, progesterone and estriol in normal pregnancy]. / Korreliatsionnye vzaimootnosheniia mezhdu soderzhaniem khorionicheskogo gonadotropina, progesterona i éstriola pri normal'noi beremennosti

A study was made of 151 healthy pregnant women at periods of from 4 to 41 weeks of pregnancy. There was revealed no correlation between the level of excretion of the CG and estriol, and also of the CG and pregnandiol from the 7th to the 41st weeks of pregnancy; consequently CG played no role in the regulation of steroidogenesis in the placenta. Between the levels of CH and progesterone in the blood there existed a significant positive association from the 4th to the 7th week of pregnancy; this correlation disappeared from the 8th week. Consequently, the CG retained its steroidogenic action on the corpus luteum of pregnancy. The activity of the corpus luteum in respect to progesterone production decreased considerably as soon as the 7th week of pregnancy.