RESUMO
Approximately 16 million people in the United States have diabetes mellitus, and the number of diagnoses is increasing at an alarming rate. A very costly disease in both human and economic terms, diabetes (currently the seventh leading cause of death) is common in both the old and young, crossing all racial, ethnic, and economic barriers. Diabetes significantly increases the risk of cardiovascular, cerebrovascular, and peripheral vascular disease, retinopathy, neuropathy, and nephropathy. The team approach to treating and managing diabetes provides a foundation of support and education for the patient, while allowing the individual control of his or her health care decisions. A self-management education program is essential for diabetes patients and their support systems to learn optimal strategies for dealing with chronic illness and the associated physical and psychological obstacles. Diabetes education must motivate and empower patients with instruction in self-monitoring techniques, proper nutrition and exercise, pharmacologic options, and psychosocial adjustments to depression and stress brought on by chronic disease, as well as provide resources for continuing education. Ochsner is developing a system-wide diabetes self-management education program as a resource for all of Louisiana and parts of Mississippi to improve the outcomes of diabetic patients. The program has demonstrated significant results since 1998 by providing a comprehensive foundation to patients and their support systems and providing a foundation for the lifelong quest to master the chronic disease process.
Assuntos
Surtos de Doenças , Infecções por Yersinia pseudotuberculosis/epidemiologia , Yersinia pseudotuberculosis/isolamento & purificação , Adolescente , Adulto , Distribuição por Idade , Colúmbia Britânica/epidemiologia , Estudos de Casos e Controles , Criança , Pré-Escolar , Intervalos de Confiança , Fezes/microbiologia , Feminino , Humanos , Incidência , Lactente , Masculino , Análise Multivariada , Razão de Chances , Fatores de Risco , Infecções por Yersinia pseudotuberculosis/diagnósticoRESUMO
Previous studies have not agreed on the incidence of ischemic stroke in persons with Parkinson's disease. There are epidemiologic and neurochemical facets of Parkinson's disease that might confer some benefit or protection against ischemic stroke. We used a case-control method to determine the lifetime history of ischemic stroke in 200 patients with Parkinson's disease and 200 controls of a similar age range. Analysis was also carried out for myocardial infarction as a marker of generalized atherosclerotic disease and for stroke risk factors. The cumulative incidence of ischemic stroke was significantly less in the patients with Parkinson's disease than in the controls, as was the cumulative incidence of myocardial infarction. Among risk factors, significantly fewer patients with Parkinson's disease used tobacco than controls. The decreased incidence of ischemic stroke in the patients with Parkinson's disease appears to be related to their less severe generalized atherosclerosis, possibly due to their lower incidence of tobacco use. In view of the known potential for dopamine to exacerbate experimental ischemic tissue damage, the possibility that the dopamine deficiency in the central nervous system of persons with Parkinson's disease confers an additional specific protective benefit against ischemic stroke cannot be excluded and requires further study.
Assuntos
Transtornos Cerebrovasculares/epidemiologia , Doença de Parkinson/epidemiologia , Idoso , Estudos de Casos e Controles , Transtornos Cerebrovasculares/complicações , Transtornos Cerebrovasculares/fisiopatologia , Feminino , Humanos , Incidência , Iowa , Masculino , Infarto do Miocárdio/complicações , Infarto do Miocárdio/epidemiologia , Infarto do Miocárdio/fisiopatologia , Doença de Parkinson/complicações , Doença de Parkinson/fisiopatologia , Estudos Retrospectivos , Fatores de RiscoRESUMO
Two-dimensional echocardiography has a high specificity for the detection of intracardiac thrombi, but technically difficult studies are often encountered. Ultrafast cardiac computed tomography may be useful in such cases. Using transthoracic two-dimensional echocardiography and ultrafast cardiac computed tomography, we studied 36 patients with cerebral ischemia; one patient had the studies performed on two occasions, making a total of 37 sets of studies. Technical difficulties occurred in 12 echocardiographic (32%) and two ultrafast cardiac computed tomographic (5%) studies. The two techniques agreed in 29 sets of studies (78%). Among the eight discrepant sets of studies, two-dimensional echocardiography was positive for a left ventricular thrombus while ultrafast cardiac computed tomography was negative in three and equivocal in one and echocardiography was equivocal while ultrafast cardiac computed tomography was negative in two and positive in one. In the latter case, a left ventricular thrombus was confirmed at autopsy. In the other discrepant set of studies echocardiography was negative while ultrafast cardiac computed tomography revealed a left atrial and appendage thrombus. Because of its ease of performance and safety, two-dimensional echocardiography is the appropriate initial screening test for left ventricular thrombus. Ultrafast cardiac computed tomography can provide additional information in patients with technically difficult or equivocal two-dimensional echocardiographic studies or patients with cardiac disorders predisposing to atrial thrombi formation.
Assuntos
Isquemia Encefálica/complicações , Doença das Coronárias/diagnóstico , Trombose Coronária/diagnóstico , Ecocardiografia , Tomografia Computadorizada por Raios X , Adulto , Idoso , Trombose Coronária/complicações , Trombose Coronária/diagnóstico por imagem , Trombose Coronária/patologia , Feminino , Humanos , Masculino , Miocárdio/patologiaRESUMO
Spontaneous circadian fluctuations of motor symptoms in Parkinson's disease (PD) often occur, with dysfunction typically less severe in the early morning than in the afternoon. In 23 PD patients with or without a history of circadian motor fluctuations, we studied contrast sensitivity (CS), a non-motor function, considered to be dependent on dopaminergic transmission to see if it exhibits similar circadian variability. We tested CS throughout the day at 2-hour intervals beginning at 8:30 AM. To facilitate multiple testing sessions, we used a rapid, printed, forced choice test of CS not requiring a motor response. We tested CS in 43 eyes in the PD patients and 23 eyes in 12 controls at spatial frequencies of 1.5, 3, 6, 12, and 18 cycles per degree (cpd). At 8:30 AM, CS in PD did not differ from that of controls, but at all other testing times it was significantly worse at 3 or more spatial frequencies. In PD, CS was significantly worse at 2:30 PM than at 8:30 AM at 3 and 6 cpd, but in controls it was unchanged throughout the day. Separate analysis of CS in PD patients, with and without a history of circadian change in motor symptoms, revealed no significant difference between the groups. These results suggest that in PD a non-motor dopaminergic function can exhibit circadian variability and that this pattern can exist in the absence of similar variability in motor symptoms. Circadian variability which parallels the most common pattern of motor variability in PD supports the notion that the CS abnormality in this condition is related to dopamine deficiency.