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1.
Eur Radiol ; 23(1): 163-73, 2013 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-22772151

RESUMO

OBJECTIVES: Computed tomography perfusion (CTP) can provide information about angiogenesis and blood-flow characteristics in tumours. [18F]Fluoro-2-deoxy-D-glucose-positron emission tomography/computed tomography (FDG-PET/CT) is one of the major oncological imaging techniques which provides information about viability of the tumour cell and partly also about its aggressiveness. The aim of the study was to investigate the relationship between FDG and CTP data in patients with head and neck cancers. MATERIALS AND METHODS: Forty-one patients with a clinically suspected head and neck cancer were prospectively included. All patients underwent a combined PET/CT with an integrated CTP examination in the area of the head and neck tumour. CTP data (BF, BV and MTT) and PET data (SUVmax, SUVmean, TLG, PETvol) were compared between tumours and (1) healthy contralateral tissue, (2) inflammatory lesions, (3) metastatic lymph nodes, and CTP data and PET data were correlated in tumours. RESULTS: Thirty-five patients had a head and neck cancer. All CTP data were statistically different between tumours, inflammatory lesions, healthy tissue and metastatic lymph nodes; PET/CT data were in part significantly different. CTP and PET parameters were not significantly correlated. CONCLUSION: CTP and PET parameters were not significantly correlated; thus, the additional CTP values provide additional insights into tumour behaviour and their glycolytic status.


Assuntos
Neoplasias de Cabeça e Pescoço/diagnóstico por imagem , Imagem Multimodal , Tomografia por Emissão de Pósitrons , Tomografia Computadorizada por Raios X , Adulto , Idoso , Biópsia , Meios de Contraste , Diatrizoato de Meglumina , Feminino , Fluordesoxiglucose F18 , Neoplasias de Cabeça e Pescoço/terapia , Humanos , Iohexol/análogos & derivados , Metástase Linfática/diagnóstico por imagem , Masculino , Pessoa de Meia-Idade , Estudos Prospectivos , Compostos Radiofarmacêuticos , Estatísticas não Paramétricas
2.
J Endovasc Ther ; 11(6): 595-604, 2004 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-15615549

RESUMO

PURPOSE: To evaluate the effect of probucol and/or of endovascular brachytherapy (EVBT) on restenosis after percutaneous transluminal angioplasty (PTA) of femoropopliteal arteries. METHODS: A total of 335 patients (206 men; mean age 72+/-9 years) with intermittent claudication were randomized according to a 2x2 factorial design to 1 of the 4 groups: probucol, placebo, EVBT, and EVBT+probucol. Probucol (1 g/d) or placebo were given in double-blinded fashion 1 month before and for 6 months after PTA. Gamma irradiation (192Iridium, 14 Gy, 5-mm reference depth) was randomly applied in an unblinded manner from a noncentered endoluminal catheter. All patients received aspirin (100 mg/d). Primary endpoint was restenosis (>50% diameter reduction) detected by duplex ultrasound 6 months after PTA. Secondary endpoints included clinical and hemodynamic assessment. RESULTS: Restenosis in patients undergoing EVBT was 17% (23/133) versus 35% (50/142) in patients without EVBT (p<0.001); in patients treated with probucol versus placebo, the rates were 23% (31/135) and 30% (43/140, p<0.001). Three quarters (77%, 102/133) of patients were free of claudication after EVBT therapy versus 61% (87/142) without EVBT (p<0.05). Need for target vessel revascularization was 6% (8/133) with EVBT versus 14% (20/142) without EVBT (p<0.01). Late thrombotic occlusions occurred in 4% (6/133), exclusively in patients treated with EVBT after stent implantation. CONCLUSIONS: Endovascular brachytherapy significantly reduces restenosis, improves symptoms, and reduces reinterventions after PTA of femoropopliteal arteries. Probucol reduces restenosis but has no additive effect when combined with brachytherapy.


Assuntos
Angioplastia com Balão/efeitos adversos , Arteriopatias Oclusivas/terapia , Aspirina/uso terapêutico , Braquiterapia , Probucol/uso terapêutico , Idoso , Idoso de 80 Anos ou mais , Análise de Variância , Angioplastia com Balão/métodos , Arteriopatias Oclusivas/diagnóstico , Feminino , Artéria Femoral/efeitos dos fármacos , Artéria Femoral/efeitos da radiação , Seguimentos , Humanos , Claudicação Intermitente/diagnóstico , Claudicação Intermitente/terapia , Masculino , Artéria Poplítea/efeitos dos fármacos , Artéria Poplítea/efeitos da radiação , Probabilidade , Recidiva , Valores de Referência , Medição de Risco , Método Simples-Cego , Resultado do Tratamento , Grau de Desobstrução Vascular/fisiologia
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