The Gender Role Attitude Scale (GRAS) as an alternative for the crisis in the measurement of attitudes towards gender roles in Latin America: a study in Chilean university students / La Escala de Actitudes de Roles de Género (GRAS) como una alternativa para la crisis en la medición de actitudes hacia los roles de género en América Latina: un estudio en universitarios chilenos

We have experienced sociocultural changes, which have favored the development of egalitarian gender role attitudes (GRA). Nevertheless, the revolution in gender roles is incomplete, and the lack of equity in social structures limits the individual experiences in equality. In the face of this reality, the scientific community is demanding a modernized system for measuring GRA. We present adaptation, evidence of factorial and convergent validity, accuracy, ceiling and floor effect, norms of interpretation by sex, and analyses of the easiest and most difficult GRAs to modify in the Gender Role Attitudes Scale (GRAS). We used a sample of 1013 Chilean university students. The GRAS has a two-factor structure that evaluates stereotyped and transcendent attitudes of gender roles in the family, social, and work contexts. The scale presents convergent validity with a sexual double standard measure and is more reliable in the low scores of transcendence and the high scores of stereotyped attitudes. Transcendent factor had a ceiling effect, and stereotyped attitudes had a floor effect. Family gender roles are the easiest to change, and work-related roles the most difficult. The authors discuss the need for a structural change to reactivate the revolution of gender roles in Chile.(AU)

Hemos experimentado cambios socioculturales que han favorecido el desarrollo de actitudes de roles de género (GRA) más igualitarias. Sin embargo, actualmente la revolución en los roles de género está incompleta y la falta de equidad en las estructuras sociales limita las experiencias individuales en igualdad. Ante esta realidad, la comunidad científica exige un sistema modernizado para medir GRA. Presentamos adaptación, evidencia de validez factorial y convergente, precisión, efecto techo y piso, normas de interpretación por sexo, y análisis del GRA más fácil y difícil de modificar, para la Escala de Actitudes de Rol de Género (EARG) en una muestra de 1013 universitarios chilenos. La EARG tiene una estructura bifactorial que evalúa actitudes estereotipadas y trascendentes en contextos familiares, sociales y laborales. Presenta validez convergente con una medida de doble estándar sexual y es más confiable en niveles bajos de trascendencia y niveles altos de actitudes estereotipadas. El factor trascendente tuvo un efecto techo, y las actitudes estereotipadas un efecto suelo. Los roles familiares de género son los más fáciles de cambiar, y los relacionados con el trabajo los más difíciles. Se discute la necesidad de un cambio estructural para reactivar la revolución de los roles de género en Chile.(AU)

Concordancia en la percepción de conductas violentas en parejas adolescentes / Concordance in the perception of violent behavior in adolescent couples

Resumen La violencia entre parejas de adolescentes es un tema de relevancia a nivel social, destacando por sus tasas de prevalencia y graves consecuencias. Como objetivo, se plantea comprobar los niveles de prevalencia de sucesos violentos en parejas adolescentes y jóvenes, y determinar los niveles de concordancia en la ocurrencia de la violencia en base a la información aportada por ambos miembros de la pareja. La muestra se conforma de 106 parejas con un rango de edad entre 18 y 30 años. Se aplicó de forma independiente el cuestionario de violencia entre novios, versión para parejas (CUVINO-VA). Los resultados reflejaron una alta prevalencia de violencia en sus relaciones de noviazgo y elevadas discrepancias en su percepción, estadísticamente significativas, tanto en varones como mujeres tanto en los roles de agresión como de victimización.

Abstract Violence between adolescent couples is a topic of social relevance, highlighted by its prevalence rates and its serious consequences. As an objective, it is proposed to check the levels of prevalence of violent events in adolescent and young couples and to determine the levels of concordance in the occurrence of violence during courtship based on the information provided by both members of the same couple. The sample consists of 106 couples with an age range between 18 and 30 years, to who was applied independently the questionnaire of violence between dating, in its version for couples (CUVINO-VA). The results reflected a high prevalence of violence in their dating relationships and high discrepancies in their perception, statistically significant, in both men and women in both the roles of aggression and victimization.

Psychosocial profiles of adults with ADHD: a comparative study of prison and outpatient psychiatric samples / Perfiles psicosociales de adultos con TDAH: un estudio comparativo con muestras reclusa y clínica

This study aimed to describe and compare the educational, social, and family profiles of adults with and without ADHD from two different settings: a prison and an outpatient psychiatric setting. A total of 542 participants, aged between 17 and 69 years, took part in the study. The participants consisted of four groups: a prison sample with ADHD (n = 69) and without ADHD (n = 183), and an outpatient psychiatric sample with ADHD (n = 218) and without ADHD (n = 72). The results showed that, firstly, there were some statistically significant differences between the groups in academic history, social and family situation, and the adoption of risk behaviors during adolescence and early adulthood. Secondly, some of these differences were related to diagnosis (ADHD versus non-ADHD) while others were related to the sample being examined (prison versus psychiatric). The findings from the study showed the presence of significant implications in social, family, educational, and employment achievements both for adults with ADHD (both prison and psychiatric samples) and for adults without ADHD

Este estudio tiene como objetivo describir y comparar los perfiles educativos, sociales y familiares de un grupo de adultos con y sin TDAH de dos muestras diferentes: una de carcelarios y una población clínica. Formaron parte del estudio 542 participantes, con edades comprendidas entre los 17 y 69 años. La muestra se dividió en cuatro grupos, un grupo de carcelarios con TDAH (n = 69) y sin TDAH (n = 183) y un grupo clínico con TDAH (n = 218) y sin TDAH (n = 72). Los resultados apoyan la hipótesis inicial, que establece que, primero, hay diferencias estadísticamente significativas entre los grupos en cuanto a historial académico, situación social y familiar y la adopción de conductas de riesgo durante la adolescencia y la adultez temprana; en segundo lugar, algunas de las diferencias se relacionarán con el diagnóstico de TDAH, mientras que otras estarán más vinculadas a la población examinada. Los hallazgos del estudio mostraron la presencia de consecuencias significativas para los contextos sociales, familiares, educativos y laborales tanto en poblaciones adultas con TDAH (pacientes en carcelarios y clínicos) como aquellas sin TDAH

Are generalist batterers different from generally extra-family violent men? A study among imprisoned male violent offenders / ¿Son los maltratadores generalistas distintos de los hombres extrafamiliarmente violentos en general? Un estudio con hombres violentos en prisión

Research on male batterers has found that in some cases of severe intimate partner violence (IPV) against women, male aggressors were also generally violent beyond the family realm. These findings have been used by researchers to illustrate the common etiology of both general and IPV. Using data from imprisoned male violent offenders, we analyzed the individual, family, and community characteristics of two groups of violent offenders: generalist batterers (GB) and generally extra-family violent men (GEVM). GB offenders had a judicial sentence on IPV-related offenses (gender violence according to the Spanish legislation), while GEVM offenders did not have any IPV-related judicial sentence. The sample includes 153 imprisoned male violent offenders of the Penitentiary Center of Villabona (Asturias, Spain). Sociodemographic measures, and criminal and justice official records of participants are available. Two groups of participants (GB and GEVM) distinction was done based on official records. Multivariate analyses of covariance (MANCOVA) was carried out to study differences between each group of participants in self-reported measures of personal, family, and community context variables. MANCOVA showed no statistical differences among the individual, family, and community characteristics of these two groups, giving empirical support to the theoretical view that general violence and IPV might share a common etiology. These results are discussed in light of the debate about the potentially common etiology of these two types of violence (AU)

En varias de las investigaciones sobre hombres maltratadores se ha demostrado que éstos no sólo son violentos contra la pareja, sino también en el ámbito extrafamiliar, lo cual ha sido utilizado por los investigadores para ilustrar la etiología común de la violencia general y la violencia en la pareja íntima (VPI). Utilizando datos de hombres violentos en prisión se han analizado las características individuales, familiares y comunitarias de dos grupos de agresores violentos: maltratadores generalistas (GB) y hombres violentos en general fuera de la familia (GEVM). Los GB fueron condenados por delitos de violencia de género (de acuerdo con la legislación española), mientras que los GEVM no han sido condenados nunca por tales delitos. La muestra está compuesta por 153 hombres internos en el Centro Penitenciario de Villabona (Asturias, España). Se ha dispuesto de variables sociodemográficas así como de registros judiciales. La distinción entre los grupos se ha establecido en base a los registros oficiales. Se han llevado a cabo análisis multivariados de covarianza (MANCOVA) para estudiar las diferencias entre los grupos de estudio en las variables individuales, familiares y comunitarias. Los resultados de los MANCOVA indican que no existen diferencias estadísticamente significativas en los ámbitos individual, familiar y comunitario entre los grupos, apoyando la perspectiva teórica que defiende que la violencia general y la VPI comparten una etiología común. Estos resultados han sido discutidos teniendo en cuenta el debate sobre la potencial etiología común de estos dos tipos de violencia (AU)

Perfil del psicópata institucionalizado sin comportamiento criminal previo a su entrada en prisión / A profile of institutionalized psycopaths without a history of criminal behavior before incarceration

La inclusión en el PCL-R del comportamiento criminal previo como criterio para la evaluación de la psicopatía en las prisiones, supone que los individuos evaluados como psicópatas en la comunidad por sus consistencias de personalidad no sean detectados al llegar a prisión. Se pretende establecer el perfil diferencial del psicópata no detectado frente al psicópata criminal a nivel familiar, educativo, de consumo y delictivo. La muestra está conformada por 352 internos en prisión que fueron evaluados mediante el PCL-R. Los resultados obtenidos confirman que el psicópata no detectado presenta mismas consistencias de personalidad que el psicópata criminal, difiriendo en el estilo de vida; exhibe variables moderadoras durante su desarrollo que le han mantenido alejado del comportamiento criminal; no ha tenido un estilo de vida delictivo, pero mantiene la misma capacidad que el psicópata criminal para la comisión de los delitos más graves, siendo víctimas más frecuentes familiares y parejas.

The previous criminal behavior included in the PCL-R like a criterion to evaluation of the psychopathy in the prisons, suppose that individuals considered as psychopaths in the community for their personality were not detected when they arrive to prison. The aim of this research was to establish the different profile of the undetected psychopath in comparison with criminal psychopath in the familiar, educative, substance abuse and criminal environments. The sample was made up of 352 prisoners evaluated with the PCL-R. Results revealed that undetected psychopath showed the same personality but different lifestyle than criminal psychopath. Moreover, undetected psychopath accounted with moderating variables during his development that avoid them committing criminal behavior. Finally they did not show a criminal lifestyle, however, as the same as a criminal psychopath, they had the capacity to commit serious crimes being their victims their relatives or couples.

Generalists versus specialists: toward a typology of batterers in prison / Generalistas frente a especialistas: hacia una tipología de maltratadores encarcelados

In this study we apply the versatile/specialist offender debate to the research of intimate partner violence. We propose the existence of two types of imprisoned male batterers: the generalist and the specialist batterer. The individual, family, and community characteristics of these types of batterers are further explored in 110 imprisoned males in the Penitentiary of Villabona (Spain). As for the individual characteristics, results indicate that the generalist batterer present higher levels of psychopathology (specially antisocial and borderline personality), sexist attitudes, and substance dependence. Specialist batterers presented higher levels of conflict in their family of origin. Finally, generalist batterers reported coming from more socially disordered communities and showed lower levels of participation and integration in these communities than the specialist batterer. These results suggest that the classical distinctions among batterers based on psychopathology and context of violence (whether general or family only) might be of little utility when applied to imprisoned male batterers (AU)

En este estudio aplicamos el debate del delincuente versátil/especialista a la investigación de la violencia de pareja. Proponemos que hay dos tipos de maltratadores masculinos en prisión: el generalista y el especialista. Se profundiza en la exploración de las características familiares, individuales y comunitarias de ambos tipos de maltratadores en 110 varones encarcelados en la prisión de Villabona (España). Sobre las características individuales los resultados indican que el maltratador generalista tiene niveles elevados de psicopatología (sobre todo personalidad antisocial y límite), actitudes sexistas y dependencia de sustancias. Los maltratadores especialistas tenían niveles elevados de conflicto con la familia de origen. Por último, los maltratadores generalistas afirmaban que procedían de comunidades más desestructuradas socialmente que los maltratadores especialistas. Estos resultados indican que la distinción clásica entre maltratadores según la psicopatología y el contexto de la violencia (únicamente la general o familiar) pudiera ser poco útil en el caso de los maltratadores masculinos encarcelados (AU)

Risk Factors for School Dropout in a Sample of Juvenile Offenders.

Backgrounds: The high rates of school dropout worldwide and their relevance highlight the need for a close study of its causes and consequences. Literature has suggested that school dropout might be explained by multiple causes at different levels (individual, family, school, and neighborhood). The aim of the current study is to examine the relation between individual (defiant attitude, irresponsibility, alcohol abuse, and illegal drugs use), family (educational figure absent and parental monitoring), school factors (truancy and school conflict) and school dropout. Method: Judicial files of all juvenile offenders (218 males and 46 females) with a judicial penal measure in Asturias (Spain) in the year 2012 were examined. Multivariate logistic regression analyses were performed to estimate the relationships between school dropout and individual, family and school variables. Results: As for the individual characteristics, results showed that school dropouts were more irresponsible than non-dropouts. Also they had higher rates of illegal drug use and alcohol abuse. Moreover, lack of parental monitoring emerged as a key predictive factor of school dropout, beyond the type of family structure in terms of the presence of both or only one educational figure. Finally, school factors did not show a significant relationship to school dropout. Conclusions: These findings indicate that school dropout is a multidimensional process. School and family policies that emphasize the role of parental monitoring and prevent alcohol and substance abuse are recommended.

Aurora kinases as prognostic biomarkers in ovarian carcinoma.

We investigated the expression of Aurora kinases A and B by immunohistochemistry in 68 ovarian carcinomas to analyze their prognostic value. The amplification of AURKA gene by fluorescence in situ hybridization was also assessed. Overall, 58.8% and 85.3% of ovarian carcinomas showed expression of Aurora A and B, respectively. Amplification of AURKA was found in 27.6% of cases examined. Tumors with Aurora A expression showed a lower rate of recurrence than those tumors without Aurora A expression (65% versus 91.7%, P = .019). In the univariate analysis, patients with Aurora A and B expression showed an increased progression-free survival (P = .023 and .06, respectively, log-rank test) and overall survival (P = .03 and .02, respectively, log-rank test). The multivariate analysis adjusted to optimal surgery by Cox proportional hazards regression showed Aurora A expression as an independent prognostic factor for progression-free survival (P = .03) and overall survival (P = .02). In conclusion, Aurora A expression seems to have a prognostic value in ovarian carcinoma.

Angiogenesis-related gene expression profile with independent prognostic value in advanced ovarian carcinoma.

BACKGROUND: Ovarian carcinoma is the most important cause of gynecological cancer-related mortality in Western societies. Despite the improved median overall survival in patients receiving chemotherapy regimens such as paclitaxel and carboplatin combination, relapse still occurs in most advanced diseased patients. Increased angiogenesis is associated with rapid recurrence and decreased survival in ovarian cancer. This study was planned to identify an angiogenesis-related gene expression profile with prognostic value in advanced ovarian carcinoma patients. METHODOLOGY/PRINCIPAL FINDINGS: RNAs were collected from formalin-fixed paraffin-embedded samples of 61 patients with III/IV FIGO stage ovarian cancer who underwent surgical cytoreduction and received a carboplatin plus paclitaxel regimen. Expression levels of 82 angiogenesis related genes were measured by quantitative real-time polymerase chain reaction using TaqMan low-density arrays. A 34-gene-profile which was able to predict the overall survival of ovarian carcinoma patients was identified. After a leave-one-out cross validation, the profile distinguished two groups of patients with different outcomes. Median overall survival and progression-free survival for the high risk group was 28.3 and 15.0 months, respectively, and was not reached by patients in the low risk group at the end of follow-up. Moreover, the profile maintained an independent prognostic value in the multivariate analysis. The hazard ratio for death was 2.3 (95% CI, 1.5 to 3.2; p<0.001). CONCLUSIONS/SIGNIFICANCE: It is possible to generate a prognostic model for advanced ovarian carcinoma based on angiogenesis-related genes using formalin-fixed paraffin-embedded samples. The present results are consistent with the increasing weight of angiogenesis genes in the prognosis of ovarian carcinoma.

Cytoplasmic localization of p120ctn and E-cadherin loss characterize lobular breast carcinoma from preinvasive to metastatic lesions.

Accumulating evidences indicate that p120 catenin, a member of the E-cadherin (E-CD)/catenin adhesion complex, plays a role in tumor invasion. To establish the expression pattern of p120 in breast cancer, we analysed 326 breast tissue biopsies by tissue microarray. Most of the lobular tumors (88%) showed exclusive cytoplasmic localization, and 6% of them also had p120 nuclear staining. Cytoplasmic p120 strongly associated with complete loss of E-CD and beta-catenin not only in lobular carcinoma and its metastases but also in atypical lobular hyperplasias. In the latter, loss of heterozygosity of E-CD gene was also observed. Complete loss of E-CD and cytoplasmic and nuclear p120 staining was also observed in primary lobular cancer cell cultures generated by us. In ductal tumors, by contrast, reduction of p120 and E-CD in membrane was very common (57 and 53%, respectively), whereas cytoplasmic p120 staining was rarely seen. This simultaneous reduction of membranous E-CD and p120 was not associated with increased Src kinase activity. To demonstrate that cytoplasmic p120 localization was a consequence of the absence of E-CD, the endogenous E-CD was re-expressed in MDA-231 cells by 5-Aza-2'-deoxycytidine (5Aza) treatment. After treatment, p120 shifted from the cytoplasm to the membrane, where it colocalized with endogenous E-CD. Additionally, suppressing E-CD expression in Madin-Darby canine kidney cells by stable transfection of the transcriptional repressors Snail, E47 or Slug, provokes p120 cytoplasmic localization and p120 isoform switching. In conclusion, abnormal cytoplasmic and nuclear localization of p120, which are mediated by the absence of E-CD, characteristically occur in the early stages of lobular breast cancer and are maintained during tumor progression to metastasis. Consequently, p120 may be an important mediator of the oncogenic effects derived from E-CD inactivation, including enhanced motility and invasion, in lobular breast cancer.

Tissue microarray immunohistochemical expression analysis of mismatch repair (hMLH1 and hMSH2 genes) in endometrial carcinoma and atypical endometrial hyperplasia: relationship with microsatellite instability.

Alterations in the mismatch repair genes (hMLH1 and hMSH2) play an important role in the development of microsatellite instability in sporadic endometrial cancer. Tissue microarray technology allows molecular profiling of tumor samples at the DNA, RNA, and protein levels. We analyzed hMLH1 and hMSH2 expression by immunohistochemistry in a group of atypical endometrial hyperplasias (n = 10), endometrioid endometrial carcinomas (n = 58), and nonendometrioid endometrial carcinomas (n = 27) on tissue microarray. The results were correlated with microsatellite instability status as evaluated by BAT-25 and BAT-26. Overall, 29.4% of lesions showed microsatellite instability. Loss of nuclear hMLH1 and hMSH2 protein expression was seen in 22.3% and 6.5% of cases, respectively. Immunohistochemistry for hMLH1 and hMSH2 showed lack of protein expression in 64% and 16.6% of microsatellite instability-positive endometrial lesions, respectively. Taken together, hMLH1 or hMSH2 protein expression was absent in 18 of 24 microsatellite instability-positive cases (75% sensitivity). A high level of concordance was found between immunohistochemistry for hMLH1 and hMSH2 and microsatellite instability status evaluated by BAT-25 and BAT-26 (kappa value of 0.7). Of the 57 cases found to be microsatellite instability negative, 53 showed normal expression of both proteins (93% specificity). The observed predictive value of absence of expression of hMLH1 for predicting microsatellite instability-positive status was 82%. The predictive value of normal expression of both proteins for predicting microsatellite instability-negative status was 90%. These results are consistent with those previously reported in whole tissue sections. Therefore, immunohistochemical analysis of hMLH1 and hMSH2 expression on tissue microarray provides an accurate technique for screening for tumors with microsatellite instability. Tissue microarrays represent an ideal approach for comparing different diagnostic or predictive markers with one another in consecutive tissue microarray sections.