Stem Cell Therapies for Restorative Treatments of Central Nervous System Ischemia-Reperfusion Injury.

Ischemic damage to the central nervous system (CNS) is a catastrophic postoperative complication of aortic occlusion subsequent to cardiovascular surgery that can cause brain impairment and sometimes even paraplegia. Over recent years, numerous studies have investigated techniques for protecting and revascularizing the nervous system during intraoperative ischemia; however, owing to a lack of knowledge of the physiological distinctions between the brain and spinal cord, as well as the limited availability of testing techniques and treatments for ischemia-reperfusion injury, the cause of brain and spinal cord ischemia-reperfusion injury remains poorly understood, and no adequate response steps are currently available in the clinic. Given the limited ability of the CNS to repair itself, it is of great clinical value to make full use of the proliferative and differentiation potential of stem cells to repair nerves in degenerated and necrotic regions by stem cell transplantation or mobilization, thereby introducing a novel concept for the treatment of severe CNS ischemia-reperfusion injury. This review summarizes the most recent advances in stem cell therapy for ischemia-reperfusion injury in the brain and spinal cord, aiming to advance basic research and the clinical use of stem cell therapy as a promising treatment for this condition.

Clinical feature of familial idiopathic basal ganglia calcification / 临床神经病学杂志

Objective To investigate the clinical features of familial idiopathic basal ganglia calcification (FIBGC).Methods Clinical data of 4 FIBGC patients from 2 families were analyzed retrospectively.Results The average age of 4 patients was(62.7 ±13.4)years old.The first symptom of 2 female patients was depression and schizophrenia, while 2 male patients displayed dementia and Parkinson's syndrome.Patients treated with vitamin D capsules,follow-up period for 3 to 6 months.All patients showed symptomatic improvement.Conclusions Clinical symptoms of FIBGC are complicated,and progressive development.The main symptom of female is mental symptoms, and male patients accompanied with dementia and dyskinesia.There is still no effective therapeutic plan for FIBGC.