OzNet: A New Deep Learning Approach for Automated Classification of COVID-19 Computed Tomography Scans.

Coronavirus disease 2019 (COVID-19) is spreading rapidly around the world. Therefore, the classification of computed tomography (CT) scans alleviates the workload of experts, whose workload increased considerably during the pandemic. Convolutional neural network (CNN) architectures are successful for the classification of medical images. In this study, we have developed a new deep CNN architecture called OzNet. Moreover, we have compared it with pretrained architectures namely AlexNet, DenseNet201, GoogleNet, NASNetMobile, ResNet-50, SqueezeNet, and VGG-16. In addition, we have compared the classification success of three preprocessing methods with raw CT scans. We have not only classified the raw CT scans, but also have performed the classification with three different preprocessing methods, which are discrete wavelet transform (DWT), intensity adjustment, and gray to color red, green, blue image conversion on the data sets. Furthermore, it is known that the architecture's performance increases with the use of DWT preprocessing method rather than using the raw data set. The results are extremely promising with the CNN algorithms using the COVID-19 CT scans processed with the DWT. The proposed DWT-OzNet has achieved a high classification performance of more than 98.8% for each calculated metric.

EEG-based emotion recognition using dual tree complex wavelet transform and random subspace ensemble classifier.

Emotions are strongly admitted as a main source to establish meaningful interactions between humans and computers. Thanks to the advancements in electroencephalography (EEG), especially in the usage of portable and cheap wearable EEG devices, the demand for identifying emotions has extremely increased. However, the overall scientific knowledge and works concerning EEG-based emotion recognition is still limited. To cover this issue, we introduce an EEG-based emotion recognition framework in this study. The proposed framework involves the following stages: preprocessing, feature extraction, feature selection and classification. For the preprocessing stage, multi scale principle component analysis and sysmlets-4 filter are used. A version of discrete wavelet transform (DWT), namely dual tree complex wavelet transform (DTCWT) is utilized for the feature extraction stage. To reduce the feature dimension size, a variety of statistical criteria are employed. For the final stage, we adopt ensemble classifiers due to their promising performance in classification problems. The proposed framework achieves nearly 96.8% accuracy by using random subspace ensemble classifier. It can therefore be resulted that the proposed EEG-based framework performs well in terms of identifying emotions.

A Deep Learning Approach for Detecting Stroke from Brain CT Images Using OzNet.

A brain stroke is a life-threatening medical disorder caused by the inadequate blood supply to the brain. After the stroke, the damaged area of the brain will not operate normally. As a result, early detection is crucial for more effective therapy. Computed tomography (CT) images supply a rapid diagnosis of brain stroke. However, while doctors are analyzing each brain CT image, time is running fast. This circumstance may lead to result in a delay in treatment and making errors. Therefore, we targeted the utilization of an efficient artificial intelligence algorithm in stroke detection. In this paper, we designed hybrid algorithms that include a new convolution neural networks (CNN) architecture called OzNet and various machine learning algorithms for binary classification of real brain stroke CT images. When we classified the dataset with OzNet, we acquired successful performance. However, for this target, we combined it with a minimum Redundancy Maximum Relevance (mRMR) method and Decision Tree (DT), k-Nearest Neighbors (kNN), Linear Discriminant Analysis (LDA), Naïve Bayes (NB), and Support Vector Machines (SVM). In addition, 4096 significant features were obtained from the fully connected layer of OzNet, and we reduced the dimension of features from 4096 to 250 using the mRMR method. Finally, we utilized these machine learning algorithms to classify important features. As a result, OzNet-mRMR-NB was an excellent hybrid algorithm and achieved an accuracy of 98.42% and AUC of 0.99 to detect stroke from brain CT images.

Automatic autism spectrum disorder detection using artificial intelligence methods with MRI neuroimaging: A review.

Autism spectrum disorder (ASD) is a brain condition characterized by diverse signs and symptoms that appear in early childhood. ASD is also associated with communication deficits and repetitive behavior in affected individuals. Various ASD detection methods have been developed, including neuroimaging modalities and psychological tests. Among these methods, magnetic resonance imaging (MRI) imaging modalities are of paramount importance to physicians. Clinicians rely on MRI modalities to diagnose ASD accurately. The MRI modalities are non-invasive methods that include functional (fMRI) and structural (sMRI) neuroimaging methods. However, diagnosing ASD with fMRI and sMRI for specialists is often laborious and time-consuming; therefore, several computer-aided design systems (CADS) based on artificial intelligence (AI) have been developed to assist specialist physicians. Conventional machine learning (ML) and deep learning (DL) are the most popular schemes of AI used for diagnosing ASD. This study aims to review the automated detection of ASD using AI. We review several CADS that have been developed using ML techniques for the automated diagnosis of ASD using MRI modalities. There has been very limited work on the use of DL techniques to develop automated diagnostic models for ASD. A summary of the studies developed using DL is provided in the Supplementary Appendix. Then, the challenges encountered during the automated diagnosis of ASD using MRI and AI techniques are described in detail. Additionally, a graphical comparison of studies using ML and DL to diagnose ASD automatically is discussed. We suggest future approaches to detecting ASDs using AI techniques and MRI neuroimaging.

LEDPatNet19: Automated Emotion Recognition Model based on Nonlinear LED Pattern Feature Extraction Function using EEG Signals.

Electroencephalography (EEG) signals collected from human brains have generally been used to diagnose diseases. Moreover, EEG signals can be used in several areas such as emotion recognition, driving fatigue detection. This work presents a new emotion recognition model by using EEG signals. The primary aim of this model is to present a highly accurate emotion recognition framework by using both a hand-crafted feature generation and a deep classifier. The presented framework uses a multilevel fused feature generation network. This network has three primary phases, which are tunable Q-factor wavelet transform (TQWT), statistical feature generation, and nonlinear textural feature generation phases. TQWT is applied to the EEG data for decomposing signals into different sub-bands and create a multilevel feature generation network. In the nonlinear feature generation, an S-box of the LED block cipher is utilized to create a pattern, which is named as Led-Pattern. Moreover, statistical feature extraction is processed using the widely used statistical moments. The proposed LED pattern and statistical feature extraction functions are applied to 18 TQWT sub-bands and an original EEG signal. Therefore, the proposed hand-crafted learning model is named LEDPatNet19. To select the most informative features, ReliefF and iterative Chi2 (RFIChi2) feature selector is deployed. The proposed model has been developed on the two EEG emotion datasets, which are GAMEEMO and DREAMER datasets. Our proposed hand-crafted learning network achieved 94.58%, 92.86%, and 94.44% classification accuracies for arousal, dominance, and valance cases of the DREAMER dataset. Furthermore, the best classification accuracy of the proposed model for the GAMEEMO dataset is equal to 99.29%. These results clearly illustrate the success of the proposed LEDPatNet19.

Artificial Intelligence-Based Breast Cancer Diagnosis Using Ultrasound Images and Grid-Based Deep Feature Generator.

Purpose: Breast cancer is a prominent cancer type with high mortality. Early detection of breast cancer could serve to improve clinical outcomes. Ultrasonography is a digital imaging technique used to differentiate benign and malignant tumors. Several artificial intelligence techniques have been suggested in the literature for breast cancer detection using breast ultrasonography (BUS). Nowadays, particularly deep learning methods have been applied to biomedical images to achieve high classification performances. Patients and Methods: This work presents a new deep feature generation technique for breast cancer detection using BUS images. The widely known 16 pre-trained CNN models have been used in this framework as feature generators. In the feature generation phase, the used input image is divided into rows and columns, and these deep feature generators (pre-trained models) have applied to each row and column. Therefore, this method is called a grid-based deep feature generator. The proposed grid-based deep feature generator can calculate the error value of each deep feature generator, and then it selects the best three feature vectors as a final feature vector. In the feature selection phase, iterative neighborhood component analysis (INCA) chooses 980 features as an optimal number of features. Finally, these features are classified by using a deep neural network (DNN). Results: The developed grid-based deep feature generation-based image classification model reached 97.18% classification accuracy on the ultrasonic images for three classes, namely malignant, benign, and normal. Conclusion: The findings obviously denoted that the proposed grid deep feature generator and INCA-based feature selection model successfully classified breast ultrasonic images.

The Ensemble Machine Learning-Based Classification of Motor Imagery Tasks in Brain-Computer Interface.

The Brain-Computer Interface (BCI) permits persons with impairments to interact with the real world without using the neuromuscular pathways. BCIs are based on artificial intelligence piloted systems. They collect brain activity patterns linked to the mental process and transform them into commands for actuators. The potential application of BCI systems is in the rehabilitation centres. In this context, a novel method is devised for automated identification of the Motor Imagery (MI) tasks. The contribution is an effective hybridization of the Multiscale Principal Component Analysis (MSPCA), Wavelet Packet Decomposition (WPD), statistical features extraction from subbands, and ensemble learning-based classifiers for categorization of the MI tasks. The intended electroencephalogram (EEG) signals are segmented and denoised. The denoising is achieved with a Daubechies algorithm-based wavelet transform (WT) incorporated in the MSPCA. The WT with the 5th level of decomposition is used. Onward, the Wavelet Packet Decomposition (WPD), with the 4th level of decomposition, is used for subbands formation. The statistical features are selected from each subband, namely, mean absolute value, average power, standard deviation, skewness, and kurtosis. Also, ratios of absolute mean values of adjacent subbands are computed and concatenated with other extracted features. Finally, the ensemble machine learning approach is used for the classification of MI tasks. The usefulness is evaluated by using the BCI competition III, MI dataset IVa. Results revealed that the suggested ensemble learning approach yields the highest classification accuracies of 98.69% and 94.83%, respectively, for the cases of subject-dependent and subject-independent problems.

A dynamic center and multi threshold point based stable feature extraction network for driver fatigue detection utilizing EEG signals.

Driver fatigue is the one of the main reasons of the traffic accidents. The human brain is a complex structure, whose function can be evaluated with electroencephalogram (EEG). Automated driver fatigue detection utilizing EEG decreases the incidence probability of related traffic accidents. Therefore, devising an appropriate feature extraction technique and selecting a competent classification method can be considered as the crucial part of the effective driver fatigue detection. Therefore, in this study, an EEG-based intelligent system was devised for driver fatigue detection. The proposed framework includes a new feature generation network, which is implemented by using texture descriptors, for fatigue detection. The proposed scheme contains pre-processing, feature generation, informative features selection and classification with shallow classifiers phases. In the pre-processing, discrete cosine transform and fast Fourier transform are used together. Moreover, dynamic center based binary pattern and multi threshold ternary pattern are utilized together to create a new feature generation network. To improve the detection performance, we utilized discrete wavelet transform as a pooling method, in which the functional brain network-based feature describing the relationship between fatigue and brain network organization. In the feature selection phase, a hybrid three layered feature selection method is presented, and benchmark classifiers are used in the classification phase to demonstrate the strength of the proposed method. In the experiments, the proposed framework achieved 97.29% classification accuracy for fatigue detection using EEG signals. This result reveals that the proposed framework can be utilized effectively for driver fatigue detection.

An automated COVID-19 detection based on fused dynamic exemplar pyramid feature extraction and hybrid feature selection using deep learning.

The new coronavirus disease known as COVID-19 is currently a pandemic that is spread out the whole world. Several methods have been presented to detect COVID-19 disease. Computer vision methods have been widely utilized to detect COVID-19 by using chest X-ray and computed tomography (CT) images. This work introduces a model for the automatic detection of COVID-19 using CT images. A novel handcrafted feature generation technique and a hybrid feature selector are used together to achieve better performance. The primary goal of the proposed framework is to achieve a higher classification accuracy than convolutional neural networks (CNN) using handcrafted features of the CT images. In the proposed framework, there are four fundamental phases, which are preprocessing, fused dynamic sized exemplars based pyramid feature generation, ReliefF, and iterative neighborhood component analysis based feature selection and deep neural network classifier. In the preprocessing phase, CT images are converted into 2D matrices and resized to 256 × 256 sized images. The proposed feature generation network uses dynamic-sized exemplars and pyramid structures together. Two basic feature generation functions are used to extract statistical and textural features. The selected most informative features are forwarded to artificial neural networks (ANN) and deep neural network (DNN) for classification. ANN and DNN models achieved 94.10% and 95.84% classification accuracies respectively. The proposed fused feature generator and iterative hybrid feature selector achieved the best success rate, according to the results obtained by using CT images.

A novel Covid-19 and pneumonia classification method based on F-transform.

Nowadays, Covid-19 is the most important disease that affects daily life globally. Therefore, many methods are offered to fight against Covid-19. In this paper, a novel fuzzy tree classification approach was introduced for Covid-19 detection. Since Covid-19 disease is similar to pneumonia, three classes of data sets such as Covid-19, pneumonia, and normal chest x-ray images were employed in this study. A novel machine learning model, which is called the exemplar model, is presented by using this dataset. Firstly, fuzzy tree transformation is applied to each used chest image, and 15 images (3-level F-tree is constructed in this work) are obtained from a chest image. Then exemplar division is applied to these images. A multi-kernel local binary pattern (MKLBP) is applied to each exemplar and image to generate features. Most valuable features are selected using the iterative neighborhood component (INCA) feature selector. INCA selects the most distinctive 616 features, and these features are forwarded to 16 conventional classifiers in five groups. These groups are decision tree (DT), linear discriminant (LD), support vector machine (SVM), ensemble, and k-nearest neighbor (k-NN). The best-resulted classifier is Cubic SVM, and it achieved 97.01% classification accuracy for this dataset.

Cloud-based ECG monitoring using event-driven ECG acquisition and machine learning techniques.

An approach is proposed for the detection of chronic heart disorders from the electrocardiogram (ECG) signals. It utilizes an intelligent event-driven ECG signal acquisition system to achieve a real-time compression and effective signal processing and transmission. The experimental results show that grace of event-driven nature an overall 2.6 times compression and bandwidth utilization gain is attained by the suggested solution compared to the counter classical methods. It results in a significant reduction in the complexity and execution time of the post denoising, features extraction and classification processes. The overall system precision is studied in terms of the classification accuracy, the F-measure, the area under the ROC curve (AUC) and the Kappa statistics. The best classification accuracy of 94.07% is attained. It confirms that the designed event-driven solution realizes a computationally efficient automatic diagnosis of the cardiac arrhythmia while achieving a high precision decision support for cloud-based mobile health monitoring.

Comparison of Bagging and Boosting Ensemble Machine Learning Methods for Automated EMG Signal Classification.

The neuromuscular disorders are diagnosed using electromyographic (EMG) signals. Machine learning algorithms are employed as a decision support system to diagnose neuromuscular disorders. This paper compares bagging and boosting ensemble learning methods to classify EMG signals automatically. Even though ensemble classifiers' efficacy in relation to real-life issues has been presented in numerous studies, there are almost no studies which focus on the feasibility of bagging and boosting ensemble classifiers to diagnose the neuromuscular disorders. Therefore, the purpose of this paper is to assess the feasibility of bagging and boosting ensemble classifiers to diagnose neuromuscular disorders through the use of EMG signals. It should be understood that there are three steps to this method, where the step number one is to calculate the wavelet packed coefficients (WPC) for every type of EMG signal. After this, it is necessary to calculate statistical values of WPC so that the distribution of wavelet coefficients could be demonstrated. In the last step, an ensemble classifier used the extracted features as an input of the classifier to diagnose the neuromuscular disorders. Experimental results showed the ensemble classifiers achieved better performance for diagnosis of neuromuscular disorders. Results are promising and showed that the AdaBoost with random forest ensemble method achieved an accuracy of 99.08%, F-measure 0.99, AUC 1, and kappa statistic 0.99.

Automatic identification of epileptic seizures from EEG signals using linear programming boosting.

BACKGROUND AND OBJECTIVE: Computerized epileptic seizure detection is essential for expediting epilepsy diagnosis and research and for assisting medical professionals. Moreover, the implementation of an epilepsy monitoring device that has low power and is portable requires a reliable and successful seizure detection scheme. In this work, the problem of automated epilepsy seizure detection using singe-channel EEG signals has been addressed. METHODS: At first, segments of EEG signals are decomposed using a newly proposed signal processing scheme, namely complete ensemble empirical mode decomposition with adaptive noise (CEEMDAN). Six spectral moments are extracted from the CEEMDAN mode functions and train and test matrices are formed afterward. These matrices are fed into the classifier to identify epileptic seizures from EEG signal segments. In this work, we implement an ensemble learning based machine learning algorithm, namely linear programming boosting (LPBoost) to perform classification. RESULTS: The efficacy of spectral features in the CEEMDAN domain is validated by graphical and statistical analyses. The performance of CEEMDAN is compared to those of its predecessors to further inspect its suitability. The effectiveness and the appropriateness of LPBoost are demonstrated as opposed to the commonly used classification models. Resubstitution and 10 fold cross-validation error analyses confirm the superior algorithm performance of the proposed scheme. The algorithmic performance of our epilepsy seizure identification scheme is also evaluated against state-of-the-art works in the literature. Experimental outcomes manifest that the proposed seizure detection scheme performs better than the existing works in terms of accuracy, sensitivity, specificity, and Cohen's Kappa coefficient. CONCLUSION: It can be anticipated that owing to its use of only one channel of EEG signal, the proposed method will be suitable for device implementation, eliminate the onus of clinicians for analyzing a large bulk of data manually, and expedite epilepsy diagnosis.

Congestive heart failure detection using random forest classifier.

BACKGROUND AND OBJECTIVES: Automatic electrocardiogram (ECG) heartbeat classification is substantial for diagnosing heart failure. The aim of this paper is to evaluate the effect of machine learning methods in creating the model which classifies normal and congestive heart failure (CHF) on the long-term ECG time series. METHODS: The study was performed in two phases: feature extraction and classification phase. In feature extraction phase, autoregressive (AR) Burg method is applied for extracting features. In classification phase, five different classifiers are examined namely, C4.5 decision tree, k-nearest neighbor, support vector machine, artificial neural networks and random forest classifier. The ECG signals were acquired from BIDMC Congestive Heart Failure and PTB Diagnostic ECG databases and classified by applying various experiments. RESULTS: The experimental results are evaluated in several statistical measures (sensitivity, specificity, accuracy, F-measure and ROC curve) and showed that the random forest method gives 100% classification accuracy. CONCLUSIONS: Impressive performance of random forest method proves that it plays significant role in detecting congestive heart failure (CHF) and can be valuable in expressing knowledge useful in medicine.

Medical Decision Support System for Diagnosis of Heart Arrhythmia using DWT and Random Forests Classifier.

In this study, Random Forests (RF) classifier is proposed for ECG heartbeat signal classification in diagnosis of heart arrhythmia. Discrete wavelet transform (DWT) is used to decompose ECG signals into different successive frequency bands. A set of different statistical features were extracted from the obtained frequency bands to denote the distribution of wavelet coefficients. This study shows that RF classifier achieves superior performances compared to other decision tree methods using 10-fold cross-validation for the ECG datasets and the obtained results suggest that further significant improvements in terms of classification accuracy can be accomplished by the proposed classification system. Accurate ECG signal classification is the major requirement for detection of all arrhythmia types. Performances of the proposed system have been evaluated on two different databases, namely MIT-BIH database and St. -Petersburg Institute of Cardiological Technics 12-lead Arrhythmia Database. For MIT-BIH database, RF classifier yielded an overall accuracy 99.33 % against 98.44 and 98.67 % for the C4.5 and CART classifiers, respectively. For St. -Petersburg Institute of Cardiological Technics 12-lead Arrhythmia Database, RF classifier yielded an overall accuracy 99.95 % against 99.80 % for both C4.5 and CART classifiers, respectively. The combined model with multiscale principal component analysis (MSPCA) de-noising, discrete wavelet transform (DWT) and RF classifier also achieves better performance with the area under the receiver operating characteristic (ROC) curve (AUC) and F-measure equal to 0.999 and 0.993 for MIT-BIH database and 1 and 0.999 for and St. -Petersburg Institute of Cardiological Technics 12-lead Arrhythmia Database, respectively. Obtained results demonstrate that the proposed system has capacity for reliable classification of ECG signals, and to assist the clinicians for making an accurate diagnosis of cardiovascular disorders (CVDs).

The effect of multiscale PCA de-noising in epileptic seizure detection.

In this paper we describe the effect of Multiscale Principal Component Analysis (MSPCA) de-noising method in terms of epileptic seizure detection. In addition, we developed a patient-independent seizure detection algorithm using Freiburg EEG database. Each patient contains datasets called "ictal" and "interictal". Window length of 16 s was applied to extract EEG segments from datasets of each patient. Furthermore, Power Spectral Density (PSD) of each EEG segment was estimated using different spectral analysis methods. Afterwards, these values were fed as input to different machine learning methods that were responsible for seizure detection. We also applied MSPCA de-noising method to EEG segments prior to PSD estimation to determine if MSPCA can further enhance the classifiers' performance. The MSPCA drastically improved both the sensitivity and the specificity, increasing the overall accuracy of all three classifiers up to 20%. The best overall detection accuracy (99.59%) was achieved when Eigenvector analysis was used for frequency estimation, and C4.5 as a classifier. The experiment results show that MSPCA is an effective de-noising method for improving the classification performance in epileptic seizure detection.

Effect of multiscale PCA de-noising on EMG signal classification for diagnosis of neuromuscular disorders.

Different approaches have been applied for quantitative analysis of EMG signals. This study introduces the effect of Multiscale Principal Component Analysis (MSPCA) denoising method in ElectroMyoGram (EMG) signal classification. The effect of the MSPCA denoising method discussed on EMG signal classification. In addition, effect of Multiple Single Classification (MUSIC) feature extraction method presented and compared for the classification of EMG signals. The results were accomplished on the basis of EMG signal data to classify into normal, ALS or myopathic. Furthermore, total accuracy of classifiers such as k-Nearest Neighbor (k-NN), Artificial Neural Network (ANN) and Support Vector Machines (SVMs) were discussed. Significant results were found by using MSPCA denoising method. The comparisons between the developed classifiers were based on a number of scalar performances such as sensitivity, specificity, accuracy, F-measure and area under ROC curve (AUC). The results show that MSPCA de-noising has considerably increased the accuracy as compared to EMG data without MSPCA de-noising.

Classification of EMG signals using PSO optimized SVM for diagnosis of neuromuscular disorders.

Support vector machine (SVM) is an extensively used machine learning method with many biomedical signal classification applications. In this study, a novel PSO-SVM model has been proposed that hybridized the particle swarm optimization (PSO) and SVM to improve the EMG signal classification accuracy. This optimization mechanism involves kernel parameter setting in the SVM training procedure, which significantly influences the classification accuracy. The experiments were conducted on the basis of EMG signal to classify into normal, neurogenic or myopathic. In the proposed method the EMG signals were decomposed into the frequency sub-bands using discrete wavelet transform (DWT) and a set of statistical features were extracted from these sub-bands to represent the distribution of wavelet coefficients. The obtained results obviously validate the superiority of the SVM method compared to conventional machine learning methods, and suggest that further significant enhancements in terms of classification accuracy can be achieved by the proposed PSO-SVM classification system. The PSO-SVM yielded an overall accuracy of 97.41% on 1200 EMG signals selected from 27 subject records against 96.75%, 95.17% and 94.08% for the SVM, the k-NN and the RBF classifiers, respectively. PSO-SVM is developed as an efficient tool so that various SVMs can be used conveniently as the core of PSO-SVM for diagnosis of neuromuscular disorders.

Medical decision support system for diagnosis of neuromuscular disorders using DWT and fuzzy support vector machines.

The motor unit action potentials (MUAPs) in an electromyographic (EMG) signal provide a significant source of information for the assessment of neuromuscular disorders. In this work, different types of machine learning methods were used to classify EMG signals and compared in relation to their accuracy in classification of EMG signals. The models automatically classify the EMG signals into normal, neurogenic or myopathic. The best averaged performance over 10 runs of randomized cross-validation is also obtained by different classification models. Some conclusions concerning the impacts of features on the EMG signal classification were obtained through analysis of the classification techniques. The comparative analysis suggests that the fuzzy support vector machines (FSVM) modelling is superior to the other machine learning methods in at least three points: slightly higher recognition rate; insensitivity to overtraining; and consistent outputs demonstrating higher reliability. The combined model with discrete wavelet transform (DWT) and FSVM achieves the better performance for internal cross validation (External cross validation) with the area under the receiver operating characteristic (ROC) curve (AUC) and accuracy equal to 0.996 (0.970) and 97.67% (93.5%), respectively. These results show that the proposed model have the potential to obtain a reliable classification of EMG signals, and to assist the clinicians for making a correct diagnosis of neuromuscular disorders.

Analysis of repetitive flash stimulation frequencies and record periods to detect migraine using artificial neural network.

Different kind of methods has been applied to detect the migraine by using flash stimulation. Especially frequency analysis of EEG signal is the most preferred method to detect the migraine by using flash stimulation. Different flash stimulation frequencies at wide frequency range have been used in migraine detection. But the effects of these flash stimulation frequencies and the most effective frequency can be determined by analyzing these frequencies separately. Since each stimulation frequency has been implemented in different time periods, it is necessary to determine the time period to detect magnitude increase in migraine patients. The aim of this study is to determine the most effective flash stimulation frequency and time duration to detect the migraine. In this study, we analyzed the flash stimulation frequencies and time duration separately for detecting migraine. Performance of each flash stimulation frequency has been determined to detect the migraine by analyzing the power spectrums obtained under 2 Hz, 4 Hz and 6 Hz and artificial neural network has been used to determine the which data has a superior performance. Afterwards we analyzed the 2 s, 4 s, 6 s, 8 s and 10 s of flash stimulation periods separately by observing the power spectrums and the results are verified by using artificial neural network. As a result of this study we proposed the 4 Hz of flash stimulation frequency is the most effective frequency and 8 s time period is necessary to detect the migraine at the beta band of EEG's T5-T3 channel.