Enhanced photocatalytic efficiencies in a bifunctional ZnO/PVA nanocomposites derived from Capparis zeylanica L.

The modern food sector demands versatile nanocomposites of polymers for food to wrappers to inactivate germs linked to foods in order to ensure quality throughout the packaging process. Recently, it has become quite appealing to use zinc oxide nanocomposite with polyvinyl alcohol (PVA) assistance for food storage containers. Variable combinations of zinc acetate and Capparis zeylanica leaf extract (3:1, 1:7, 1:3, and 1:1) were used to create nanostructured ZnO at the desired pH (10.5). ZnO/PVA nanocomposites films were created with different weight % of (16, 13, 9 and 5%) ZnO nanoparticles by using solution casting method. The generated ZnO and ZnO/PVA nanocomposites (NCs) were characterized using analytical techniques like X-ray diffraction spectroscopy (XRD), ultraviolet spectroscopic analysis (UV-Vis), Fourier-transform infrared analysis (FT-IR), and field emission scanning electron microscopic study (FE-SEM). The generated ZnO and ZnO/PVA NCs were tested for their efficacy as antibacterial agents against Gram + ve (Streptococcus pyogenes, Staphylococcus aureus) and Gram -ve (Pseudomonas aeruginosa, and E. coli) bacteria. Under UV-visible irradiation, the methylene blue (MB) breakdown caused by the fabricated undoped ZnO and ZnO/PVA nanomixture was investigated. The FE-SEM investigation for synthesized ZnO from a 1:1 ratio exhibited spherical shaped appearance. However, the nanocomposite made with 5% ZnO showed equally scattered nanoflake particles in the matrix of PVA film as well as on the surface. The XRD results showed that ZnO synthesized with a higher proportion of plant extract produced smaller crystallites, whereas ZnO synthesized with a lower percentage of plant extract produced bigger crystallite sizes. The optimum concentration for the breakdown of methylene blue (MB) among the various concentrations examined was 5% ZnO/PVA. Furthermore, a study of the biomedical efficiency of undoped ZnO and ZnO/PVA revealed that 5% ZnO/PVA had the potential antibacterial efficacies.

Bioremediations analysis using multifactorial porous materials derived from tea residue.

Titanium dioxide nanoparticles (TiO2 NPs) are becoming more and more renowned as biocompatible nanomaterials with diverse biological functions. In the present study, the aqueous extract of tea residue (tea filtered waste powder) was used to synthesize the TiO2 NPs and treated for effluent bioremediations. Maximum absorption in the UV-Vis spectrum of the TiO2 NPs was seen at 358 nm, and the XRD pattern reveals peaks at 2 h values of 25.78, 38.24, 47.98, 54.76, 55.32, 62.64, 69.05, 70.15, 75.24, and 83.59 that may be indexed to the (101), (004), (200), (105), (211), (204), (116), (220), (215) and (303). The FT-IR spectra of TiO2 NPs showed a peak at 3420, 2925, 1621, 1382, 1098, and 687 cm-1. The spherical form and size were disclosed by FE-SEM analyses, and the EDAX pattern verified the purity of the TiO2 NPs. The average particles size of the TiO2 NPs was 32 nm. The photodegradation of paper mill waste water is significantly deteriorated up to 99.08% for 600 min, but textile waste water is degraded up to 98.06% for the same duration. Furthermore, we reported that TiO2 NPs may rapidly breakdown industrially hazardous effluents when exposed to sunshine. Overall, this new, straightforward, and environmentally beneficial strategy may be of interest to the management of efficient degradation of dye solutions in the polluted regions.

Molecular docking and ADME properties of bioactive molecules against human acid-beta-glucosidase enzyme, cause of Gaucher's disease.

Gaucher disease is one of the common lysosomal storage diseases widespread all over the world. It is divided into three types such as type 1 (non-neuropathic), type 2 (acute infantile neuropathic) and type 3 (chronic neuropathic). This is caused by the deficiency of glucocerebrosidases from the midpoint nervous system. Recent years, computational tools are very important and play a vital role in identifying new leads for disease treatment. This study was performed to screen the effective bioactive molecules against glucocerebrosidases. In this study, Molecular docking and ADME profiles of bioactive molecules were found with the help of Schrödinger software. Results showed that, (-)-epicatechin are having best docking score and good binding affinity than other ligands. Hence, we concluded that the (-)-epicatechin may be a better drug candidate for gaucher disease which can be explored further.

In silico prediction of monovalent and chimeric tetravalent vaccines for prevention and treatment of dengue fever.

Reverse vaccinology method was used to predict the monovalent peptide vaccine candidate to produce antibodies for therapeutic purpose and to predict tetravalent vaccine candidate to act as a common vaccine to cover all the fever dengue virus serotypes. Envelope (E)-proteins of DENV-1-4 serotypes were used for vaccine prediction using NCBI, Uniprot/Swissprot, Swiss-prot viewer, VaxiJen V2.0, TMHMM, BCPREDS, Propred-1, Propred and MHC Pred,. E-proteins of DENV-1-4 serotypes were identified as antigen from which T cell epitopes, through B cell epitopes, were predicted to act as peptide vaccine candidates. Each selected T cell epitope of E-protein was confirmed to act as vaccine and to induce complementary antibody against particular serotype of dengue virus. Chimeric tetravalent vaccine was formed by the conjugation of four vaccines, each from four dengue serotypes to act as a common vaccine candidate for all the four dengue serotypes. It can be justifiably concluded that the monovalent 9-mer T cell epitope for each DENV serotypes can be used to produce specific antibody agaomst dengue virus and a chimeric common tetravalent vaccine candidate to yield a comparative vaccine to cover any of the four dengue virus serotype. This vaccine is expected to act as highly immunogenic against preventing dengue fever.