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1.
J Orthop Surg (Hong Kong) ; 30(3): 10225536221125949, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-36189649

RESUMO

PURPOSE: To thoroughly compare the outcomes between exposed and buried Kirschner wires (K-wires) in fixation for pediatric supracondylar humerus fractures. METHODS: We examined patients who underwent surgery at our institution between January 2007 and June 2021. We investigated their age, sex, fracture pattern, number of K-wires used, whether they were exposed or buried, operative time, postoperative complications, number of outpatient visits, duration from surgery to K-wire removal, total length of hospitalization, and perioperative radiographic parameters. After propensity score matching, intergroup comparisons were performed to assess the differences in postoperative complication rate, number of outpatient visits, duration from surgery to K-wire removal, total length of hospitalization, and loss of reduction. RESULTS: Propensity score matching resulted in 43 pairs in both groups. Although more patients complained of skin irritation in the buried K-wire group, there was more backing out of the K-wire in the exposed K-wire group (p < 0.01). There were no significant differences in other complications. There were more outpatient visits in the buried K-wire group (p < 0.01). The duration from surgery to K-wire removal and the total length of hospitalization were significantly longer in the buried K-wire group (p < 0.01). There was no significant difference in the loss of Baumann's angle (p = 0.61), tilting angle (p = 0.48), or the development of rotation (p > 0.99) between groups. CONCLUSION: More outpatient visits and longer lengths of hospitalization in the buried K-wire group may lead to increased costs and burden on parents.


Assuntos
Fios Ortopédicos , Fraturas do Úmero , Criança , Fixação Interna de Fraturas/métodos , Humanos , Fraturas do Úmero/cirurgia , Úmero , Complicações Pós-Operatórias , Pontuação de Propensão
2.
J Hand Surg Asian Pac Vol ; 27(3): 541-547, 2022 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-35674260

RESUMO

Background: We have been using a simplified Sauvé-Kapandji (SK) procedure using a headless compression screw for the treatment of osteoarthritis (OA) of the distal radio-ulnar joint (DRUJ). Unlike a standard SK procedure, the simplified SK procedure does not require exposure of the DRUJ to prepare the opposing surfaces of the sigmoid fossa and the ulnar head or any procedures to stabilise the proximal stump of the ulna. The aim of this study is to report the radiological outcomes of the simplified SK procedure. Methods: We retrospectively reviewed data of all patients who underwent a simplified SK procedure for osteoarthritis of the DRUJ at our hospital between October 2008 and September 2020 with a follow-up of at least 25 weeks. Baseline demographic and clinical characteristics were investigated. We also measured radiographic parameters and performed statistical analyses to evaluate the shelf-forming region, ulnar stump and deviation of the carpal region. Results: Our study included 10 patients with a mean follow-up of 52.3 weeks. There was no instance of complications such as nonunion of DRUJ arthrodesis, callus formation at ulnar pseudoarthrosis and painful instability at the proximal stump of the ulna. According to the Wilcoxon signed rank test, no radiographic parameters significantly changed during the follow-up period. There was a significant negative correlation between radioulnar width and the variation of ulnar translation index. Conclusions: All radiographic parameters were well maintained, at least during the short follow-up period. There was no instance of nonunion of DRUJ arthrodesis. The simplified SK with simple headless compression screw insertion may be a reliable method for treating OA of the DRUJ. Level of Evidence: Level IV (Therapeutic).


Assuntos
Osteoartrite , Articulação do Punho , Humanos , Osteoartrite/diagnóstico por imagem , Osteoartrite/cirurgia , Radiografia , Estudos Retrospectivos , Ulna/diagnóstico por imagem , Ulna/cirurgia , Articulação do Punho/diagnóstico por imagem , Articulação do Punho/cirurgia
3.
JPRAS Open ; 32: 144-149, 2022 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-35445150

RESUMO

The profunda femoris artery perforator flap (PAP) based on a proximal skin perforator is often used for breast reconstruction. We report two cases of lateral knee joint reconstruction using a PAP flap based on a distal skin perforator. Case 1 is a 16-year-old male adolescent who underwent inappropriate resection of a synovial sarcoma on the lateral aspect of the right knee joint, which necessitated additional wide resection that led to a soft tissue defect measuring 11 × 5 cm. We elevated a propeller PAP flap (23 × 7 cm) for defect reconstruction, and the flap survived completely. Case 2 is an 81-year-old woman who underwent wide resection of an undifferentiated pleomorphic sarcoma on the lateral aspect of the right knee joint showed a persistent soft tissue defect measuring 9 × 6 cm. We elevated a propeller PAP flap (25 × 7 cm) as described in Case 1, and the flap survived completely. Skin perforators of the profunda femoris artery are present both in the proximal and distal thigh; therefore, a PAP flap can also be elevated in the distal thigh. However, a few reports have discussed PAP flap elevation in the distal thigh for knee joint reconstruction. The PAP flap with a distal skin perforator can be elevated with a relatively large volume of skin paddle and may be a useful option for lateral knee joint reconstruction.

4.
Injury ; 53(6): 2074-2080, 2022 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-35236572

RESUMO

INTRODUCTION: Research regarding the epidemiology of paediatric trauma is limited. Using our unique classification, we describe paediatric trauma cases in a 10-year single-centre study to improve paediatric care. MATERIALS AND METHODS: Data regarding all paediatric trauma cases were extracted using a computerised medical record system that detected fracture diagnosis and epiphyseal injury. Registry search identified cases from January 2008 to December 2017. Age, sex, type of fracture, and details of injury mechanism were analysed, and we categorised the 'falls/turnover' mechanism using a new trauma energy classification based on speed and height. RESULTS: A total of 1379 cases (953 boys and 426 girls) were included. The highest number of injuries (553 cases, 40%) was seen in school children (aged 6 to 10 years). Forearm fracture occurred most frequently, followed by humeral fracture. The most frequent injury mechanism in falls/turnover (969 cases, 70%) was sports in 272 cases (28%), playground equipment in 179 cases (18%), furniture in 102 cases (11%), and bicycling in 87 cases (9%). We classified 956 cases of falls/turnover using our trauma energy classification scheme. Most cases (29%) were classified into the L2 category (low height and high speed), followed by the L1 category (low height and low speed) (p < 0.01). Subcategory analysis using the classification revealed that younger children were more likely to be injured by falling from high places because of their physique, whereas older children were more likely to be injured by a turnover from lower places and at higher speed. CONCLUSION: We describe the epidemiology of fractures in detail and present a new classification system, which may aid in understanding the injury mechanism independent of children's height. The fact that paediatric fractures occur at relatively low energy levels and are trended by age, activity, and sex, could be of potential universal use for their prevention and parent education.


Assuntos
Fraturas do Úmero , Adolescente , Criança , Feminino , Humanos , Fraturas do Úmero/epidemiologia , Masculino , Sistema de Registros , Estudos Retrospectivos
5.
JPRAS Open ; 32: 13-17, 2022 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-35242983

RESUMO

We describe a patient in whom the deep inferior epigastric artery served as a collateral pathway to the lower extremities, and free latissimus dorsi myocutaneous flap transfer was successfully used for reconstruction instead of the originally planned free rectus abdominis myocutaneous flap. A 74-year-old woman underwent subtotal tongue resection, followed by free flap tongue reconstruction for tongue cancer. Reconstruction using a free rectus abdominis myocutaneous flap was considered; however, preoperative contrast-enhanced computed tomography revealed complete occlusion of the bilateral external iliac arteries. Doppler ultrasonography revealed retrograde blood flow via the deep inferior epigastric artery, and the internal thoracic artery-deep inferior epigastric artery pathway served as a collateral pathway that supplied the lower extremities. The patient underwent reconstructive surgery using a free latissimus dorsi myocutaneous flap, and the flap completely survived. The internal thoracic artery-deep inferior epigastric artery pathway serves as a critical collateral pathway to the lower extremities in patients with aortoiliac occlusive disease. Blockage of the deep inferior epigastric artery in patients in whom this vessel shows retrograde blood flow may result in lower extremity ischemia. Therefore, preoperative Doppler ultrasonography is warranted to confirm the direction of the blood flow, in addition to evaluation of the deep inferior epigastric artery and its perforators before planning rectus abdominis myocutaneous flap or deep inferior epigastric artery perforator flap surgery.

6.
JPRAS Open ; 30: 91-96, 2021 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-34522755

RESUMO

Pacinian corpuscle hyperplasia is a pathological increase in the size (Pacinian hypertrophy) and/or density of mature Pacinian corpuscles. Although its aetiology and pathogenesis remain unclear, surgery is the main treatment. Here, we report a rare case of Pacinian hypertrophy at the fingertip treated with surgical excision and reconstruction using a reverse digital artery flap. A 47-year-old man presented with injuries to his right little finger, which was wedged in a door while unloading a truck. His fingertip was amputated and stump plasty was performed. However, severe pain persisted at the fingertip for 5 months after the surgery. Therefore, the painful part of his fingertip was resected, and reconstruction was performed using a reverse digital artery flap 6 months after the injury. Haematoxylin and eosin staining of the resected specimen revealed scar tissue with foreign body reaction and mild Pacinian hypertrophy. One year has passed since the injury, and the pain has completely disappeared. The patient regained complete range of motion in his little finger and was able to resume work without any limitations. Surgical excision with sufficient margin and reconstruction with a reverse digital artery flap is a reliable method to relieve pain due to Pacinian hypertrophy at the fingertip.

7.
Int J Mol Sci ; 22(16)2021 Aug 11.
Artigo em Inglês | MEDLINE | ID: mdl-34445330

RESUMO

We investigated injury-induced heat shock protein 27 (HSP27) expression and its association to axonal outgrowth after injury and different nerve repair models in healthy Wistar and diabetic Goto-Kakizaki rats. By immunohistochemistry, expression of HSP27 in sciatic nerves and DRG and axonal outgrowth (neurofilaments) in sciatic nerves were analyzed after no, immediate, and delayed (7-day delay) nerve repairs (7- or 14-day follow-up). An increased HSP27 expression in nerves and in DRG at the uninjured side was associated with diabetes. HSP27 expression in nerves and in DRG increased substantially after the nerve injuries, being higher at the site where axons and Schwann cells interacted. Regression analysis indicated a positive influence of immediate nerve repair compared to an unrepaired injury, but a shortly delayed nerve repair had no impact on axonal outgrowth. Diabetes was associated with a decreased axonal outgrowth. The increased expression of HSP27 in sciatic nerve and DRG did not influence axonal outgrowth. Injured sciatic nerves should appropriately be repaired in healthy and diabetic rats, but a short delay does not influence axonal outgrowth. HSP27 expression in sciatic nerve or DRG, despite an increase after nerve injury with or without a repair, is not associated with any alteration in axonal outgrowth.


Assuntos
Proteínas de Choque Térmico HSP27/metabolismo , Regeneração Nervosa/fisiologia , Crescimento Neuronal/fisiologia , Traumatismos dos Nervos Periféricos , Animais , Diabetes Mellitus Experimental/metabolismo , Diabetes Mellitus Experimental/fisiopatologia , Feminino , Traumatismos dos Nervos Periféricos/metabolismo , Traumatismos dos Nervos Periféricos/fisiopatologia , Ratos , Ratos Wistar , Células de Schwann/metabolismo , Células de Schwann/fisiologia , Nervo Isquiático/metabolismo , Nervo Isquiático/fisiopatologia , Neuropatia Ciática/metabolismo , Neuropatia Ciática/fisiopatologia , Regulação para Cima
8.
JPRAS Open ; 28: 66-71, 2021 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-33786359

RESUMO

Spontaneous attritional extensor tendon ruptures of the index finger due to carpal bone lesions are uncommon. Here, we report the case of a patient with a spontaneous rupture of the extensor indicis proprius (EIP) and index extensor digitorum communis (EDC2) tendons due to a previously symptomatic dorsal scaphoid osteophyte. A healthy 60-year-old man with right-hand dominance experienced mild pain over the dorsum of his left hand for no particular cause. He was a maker of tatami mats. Nine months later, he noted a sudden snap on the dorsum of his right hand while he was making tatami mats and he became unable to extend his index finger. Plain radiography revealed an osteophyte on the dorsal side of the scaphoid. Computed tomography revealed a bone fragment on the dorsal side between the scaphoid and lunate, which seemed to be derived from the scaphoid osteophyte. He underwent surgery 24 days after the incident. First, the fragment was excised; then tendon transfer was performed. EIP and EDC2 tendons were bundled using a side-to-side suture and connected to the middle extensor digitorum communis tendon using interlacing sutures. Histopathological findings of the resected bone were compatible with osteoarthritic change. Tatami mat making requires repeated radioulnar deviation, which could be a risk factor for scaphoid osteophytes. To our knowledge, the present case is the first to report extensor tendon rupture due to a scaphoid osteophyte in a healthy person. Although there is no consensus on the appropriate management of symptomatic scaphoid osteophytes, early intervention at the first sign of tenosynovitis might be necessary to prevent extensor tendon ruptures.

9.
Trauma Case Rep ; 32: 100408, 2021 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-33665305

RESUMO

Osteomyelitis of the epiphysis after a distal radius fracture is uncommon. If not adequately and promptly treated, the detrimental effects on wrist function can be devastating. However, management of septic bone defects of the epiphysis is significantly challenging. We report the case of a patient with juxta-articular distal radius osteomyelitis successfully treated with a free vascularised corticoperiosteal flap from the medial femoral condyle (MFC corticoperiosteal flap). A 46-year-old right-handed man fell on the grass from a height of 2 m during a demolition. He was diagnosed with a right distal radius and ulnar styloid process fracture. He underwent open reduction and internal fixation. However, he developed a deep infection, resulting in postoperative osteomyelitis. Therefore, thorough debridement was performed and an external fixator was applied. Antibiotics were administered according to the culture results. He underwent reconstruction for bone defect using an MFC corticoperiosteal flap 28 days after re-operation. The patient could resume work without limitations 4 months after the reconstruction. The infection subsided completely, and radiographs confirmed bone union at 5 months after the reconstruction. His wrist range of motion was 40° in dorsal flexion (uninjured side 70°), 50° in palmar flexion (75°), 80° in supination (90°), and 90° in pronation (90°). There was no donor site complication. The patient has reported no pain for 1 year since the injury. The use of the MFC corticoperiosteal flap for reconstruction of the juxta-articular distal radius osteomyelitis decreased the time required for bone union, enabled local antibiotic delivery to control infection, and helped preserve wrist function.

10.
Adv Orthop ; 2021: 8886063, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-33628514

RESUMO

PURPOSE: Elevation of the sural artery flap with the sural nerve is associated with donor-site morbidities, such as postoperative sensory disturbance of the lower extremity. We evaluated the sensory disturbance of the lower extremity after elevation of the sural artery flap. METHODS: This study included 7 patients who underwent surgery using the sural artery flap. The sensory disturbances immediately after surgery and at present were evaluated on a 10-point scale. The influences of surgery on activities of daily living and patient satisfaction were also evaluated. RESULTS: The sensory disturbance was 4.48 immediately after surgery and 2.24 presently, and the difference between the timepoints was not statistically significant. The influence of surgery on activities of daily living was 2.30, and the patient satisfaction was 7.90. CONCLUSION: It may be necessary to consider the sural artery flap, which does not include the sural nerve, to avoid unnecessary complications. When it is unavoidable to use the sural artery flap, including the sural nerve, it is important to thoroughly inform patients beforehand about the postsurgery sensory disturbance in the lower extremities.

11.
Eur J Orthop Surg Traumatol ; 31(2): 399-406, 2021 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-32909106

RESUMO

BACKGROUND: Although it is important to understand the risk factors affecting the reduction of pediatric supracondylar humerus fractures (PSHFs), no inclusive study has been conducted so far. We performed a retrospective cohort study to identify the risk factors affecting the quality and difficulty of reduction for PSHFs. METHODS: We reviewed 160 cases with a PSHF that had been surgically treated in our hospital between January 2007 and December 2019. We investigated age, sex, injured side, body mass index (BMI), modified Gartland classification, neurological deficit or an absent radial artery pulse at an initial examination, start time of the operation, waiting time from injury to surgery, operative time, reduction technique, and perioperative radiographic parameters. We calculated independent predictors of unsuccessful closed reduction, prolonged operative time, and malreduction using multivariate analyses. RESULTS: In a logistic regression analysis, modified Gartland type III was a significant predictor of unsuccessful closed reduction (OR 14.50 [95% CI 4.03-51.90]; P < 0.01) and BMI was a significant predictor of malrotation (OR 1.59 [95% CI 1.06-2.39]; P = 0.025). In a multiple linear regression analysis, BMI and open reduction were significant predictors of prolonged operative time (BMI, P = 0.011; open reduction, P < 0.01). CONCLUSIONS: If closed reduction fails, we should not hesitate to immediately switch to other methods. Obesity was an independent predictor of both prolonged operative time and malrotation, a finding that has not been previously reported. Rotational alignment should be carefully checked, especially for obese children, and accurately be reduced. Open reduction also extended operative time.


Assuntos
Fraturas do Úmero , Obesidade Infantil , Criança , Humanos , Fraturas do Úmero/diagnóstico por imagem , Fraturas do Úmero/cirurgia , Úmero , Redução Aberta , Estudos Retrospectivos
12.
J Hand Surg Asian Pac Vol ; 25(2): 226-231, 2020 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-32312197

RESUMO

Background: Pediatric supracondylar humerus fracture (PSHF) is one of the most common fractures of the elbow seen among boys aged between 5 and 7 years. The timing of surgical treatment for this type of fracture is still controversial. Thus, we aimed to investigate whether the timing of surgery for PSHFs affects the incidence of early postoperative complications and reduction of PSHFs. Methods: We retrospectively reviewed the medical records of PSHF patients who underwent surgery at our hospital between January 2007 and March 2019. We classified patients who underwent surgery within 12 h and more than 12 h after the fracture as the early and delayed groups, respectively. The outcome measures compared between the two groups were the incidence of postoperative early complications such as neurological deficits, including iatrogenic ulnar nerve injury, vascular compromise, compartment syndrome, K-wire migration, and unplanned returns to the operating room. We also examined surgical time, reduction procedure, and perioperative radiographic parameters. Results: There was no significant difference in the incidence of early complications between the early and delayed groups for either modified Gartland type II or type III fractures. There was also no significant difference in surgical time, reduction procedure, or perioperative radiographic parameters between the two groups. Conclusions: Delayed surgery was not associated with an increased rate of postoperative early complications in either type II or type III fractures. The timing of surgery does not affect the difficulty or quality of reduction.


Assuntos
Fixação Interna de Fraturas/efeitos adversos , Fraturas do Úmero/cirurgia , Complicações Pós-Operatórias/epidemiologia , Tempo para o Tratamento , Fatores Etários , Fios Ortopédicos , Criança , Pré-Escolar , Feminino , Humanos , Incidência , Masculino , Estudos Retrospectivos , Fatores de Tempo
13.
Muscle Nerve ; 62(1): 119-127, 2020 07.
Artigo em Inglês | MEDLINE | ID: mdl-32243602

RESUMO

INTRODUCTION: Many reports have indicated that adipose-derived stem cells (ADSCs) are effective for nerve regeneration. We investigated nerve regeneration by combining a polyglycolic acid collagen (PGA-c) tube, which is approved for clinical use, and Schwann cell-like differentiated ADSCs (dADSCs). METHODS: Fifteen-millimeter-long gaps in the sciatic nerve of rats were bridged in each group using tubes (group I), with tubes injected with dADSCs (group II), or by resected nerve (group III). RESULTS: Axonal outgrowth was greater in group II than in group I. Tibialis anterior muscle weight revealed recovery only in group III. Latency in nerve conduction studies was equivalent in group II and III, but action potential was lower in group II. Transplanted dADSCs maintained Schwann cell marker expression. ATF3 expression level in the dorsal root ganglia was equivalent in groups II and III. DISCUSSION: dADSCs maintained their differentiated state in the tubes and are believed to have contributed to nerve regeneration.


Assuntos
Tecido Adiposo/fisiologia , Diferenciação Celular/fisiologia , Regeneração Nervosa/fisiologia , Células de Schwann/fisiologia , Nervo Isquiático/fisiologia , Transplante de Células-Tronco/métodos , Tecido Adiposo/citologia , Tecido Adiposo/transplante , Animais , Diferenciação Celular/efeitos dos fármacos , Colágeno/administração & dosagem , Feminino , Regeneração Nervosa/efeitos dos fármacos , Nervos Periféricos/efeitos dos fármacos , Nervos Periféricos/fisiologia , Ácido Poliglicólico/administração & dosagem , Ratos , Ratos Wistar , Células de Schwann/transplante , Nervo Isquiático/efeitos dos fármacos , Neuropatia Ciática/fisiopatologia , Neuropatia Ciática/terapia , Células-Tronco/fisiologia
14.
J Hand Surg Asian Pac Vol ; 22(3): 337-342, 2017 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-28774249

RESUMO

BACKGROUND: Chronic tenosynovitis of the wrist and hand is commonly seen by orthopedists, especially hand surgeons. However, cases with rice body formation are comparatively rare. Thus, we retrospectively reviewed the cases of chronic tenosynovitis in our department and evaluated the necessity of antibiotic therapy in the early post-surgical stage. METHODS: We analyzed the medical and surgical records of patients who had undergone surgery for chronic tenosynovitis with rice body formation in our department from 1997 to 2015. We evaluated the causes of chronic tenosynovitis, culture findings, pathological findings, and post-operative treatment courses. RESULTS: Nineteen patients with 23 involved hands underwent surgery for chronic tenosynovitis, and 9 patients had rice body formation. The most common cause of chronic tenosynovitis was non-tuberculous mycobacteriosis, and other causes were fungal infection and infection of unknown origin. Recurrence was observed in 2 cases of mycobacteriosis and 1 case of fungal infection; 1 case of mycobacteriosis also had a re-recurrence. CONCLUSIONS: In the diagnosis of chronic tenosynovitis with rice body formation, it is necessary to consider not only non-tuberculous mycobacteriosis, but also fungal infection as its origin. However, it is difficult to define the cause of synovitis, but in cases in which these infections are suspected, anti-bacterial therapy in the early post-surgical period could be effective.


Assuntos
Fungos/isolamento & purificação , Micobactérias não Tuberculosas/isolamento & purificação , Tenossinovite/microbiologia , Tenossinovite/patologia , Idoso , Idoso de 80 Anos ou mais , Antibacterianos/uso terapêutico , Doença Crônica , Feminino , Articulação da Mão , Humanos , Masculino , Pessoa de Meia-Idade , Recidiva , Estudos Retrospectivos , Tenossinovite/terapia
15.
J Hand Surg Asian Pac Vol ; 22(2): 232-235, 2017 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-28506178

RESUMO

The Galeazzi-equivalent fracture is a rare injury that occurs in children. The most important issue is the distal ulnar epiphyseal injury. Although there have been some case reports, most of them performed only short term follow-up. This article describes two cases of this fracture with long term follow-up until epiphyseal closure. First case is a 12-year-old girl who sustained a Galeazziequivalent fracture of her right forearm and underwent emergency surgery. At follow-up of 5 years and 10 months postsurgery, radiographs show ulnar growth arrest of one mm and she has mild pain. Second case is a 15-year-old boy who sustained an open Galeazzi-equivalent fracture of his left forearm and underwent emergency surgery. At follow-up of 3 years and 3 months postsurgery, radiographs show no growth arrest of the distal ulna. He has no residual complaint. Long term follow-up is absolutely necessary to monitor ulnar growth.


Assuntos
Fratura-Luxação/cirurgia , Fraturas do Rádio/cirurgia , Adolescente , Criança , Feminino , Antebraço , Fratura-Luxação/diagnóstico por imagem , Fratura-Luxação/etiologia , Humanos , Masculino , Radiografia , Fraturas do Rádio/diagnóstico por imagem , Fraturas do Rádio/etiologia
17.
Biomaterials ; 76: 33-51, 2016 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-26517563

RESUMO

Biosynthetic nerve grafts are developed in order to complement or replace autologous nerve grafts for peripheral nerve reconstruction. Artificial nerve guides currently approved for clinical use are not widely applied in reconstructive surgery as they still have limitations especially when it comes to critical distance repair. Here we report a comprehensive analysis of fine-tuned chitosan nerve guides (CNGs) enhanced by introduction of a longitudinal chitosan film to reconstruct critical length 15 mm sciatic nerve defects in adult healthy Wistar or diabetic Goto-Kakizaki rats. Short and long term investigations demonstrated that the CNGs enhanced by the guiding structure of the introduced chitosan film significantly improved functional and morphological results of nerve regeneration in comparison to simple hollow CNGs. Importantly, this was detectable both in healthy and in diabetic rats (short term) and the regeneration outcome almost reached the outcome after autologous nerve grafting (long term). Hollow CNGs provide properties likely leading to a wider clinical acceptance than other artificial nerve guides and their performance can be increased by simple introduction of a chitosan film with the same advantageous properties. Therefore, the chitosan film enhanced CNGs represent a new generation medical device for peripheral nerve reconstruction.


Assuntos
Quitosana/uso terapêutico , Neuropatias Diabéticas/tratamento farmacológico , Regeneração Nervosa/efeitos dos fármacos , Animais , Quitosana/farmacologia , Neuropatias Diabéticas/fisiopatologia , Ratos , Ratos Wistar
18.
Hand Surg ; 19(3): 343-7, 2014.
Artigo em Inglês | MEDLINE | ID: mdl-25121940

RESUMO

We hypothesized that wrist joint motion involves a "wrist rhythm" similar to the scapulohumeral rhythm. Therefore, we used a flat-panel detector to evaluate the ratio of radiolunate and capitolunate joint motions during wrist joint motion by dynamic radiography. The subjects were 20 healthy men. Dynamic imaging of the wrist joint was performed during active exercise for a total of ten seconds. In this study, we defined the radiocarpal (RL angle) and midcarpal joint angle (CL angle) as the wrist joint angle in the obtained images and measured the variation of these angles. The average curve was plotted and regression lines calculated from the average curve. The ratio was calculated from the slopes of the regression lines of the RL CL angles. These findings indicated that the ratio of the RL and CL angle motions was approximately 1:4 during palmar flexion and approximately 2:1 during dorsiflexion.


Assuntos
Articulações do Carpo/diagnóstico por imagem , Articulações do Carpo/fisiologia , Amplitude de Movimento Articular/fisiologia , Articulação do Punho/diagnóstico por imagem , Articulação do Punho/fisiologia , Adulto , Humanos , Processamento de Imagem Assistida por Computador , Masculino , Movimento/fisiologia , Radiografia , Valores de Referência , Adulto Jovem
19.
Eur J Orthop Surg Traumatol ; 24(8): 1425-9, 2014 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-24487718

RESUMO

BACKGROUND: We have proposed that a positive tendon irritation test is suggestive of flexor pollicis longus (FPL) tendon damage that can lead to tendon rupture after volar plate fixation for distal radius fractures. We investigated cases of postsurgical hardware removal and validated the tendon irritation test as a way to elicit a sign of FPL tendon irritation. PATIENTS AND METHODS: We performed hardware removal from 30 wrists in 28 consecutive patients after volar plate fixation. Subjects included 9 men and 19 women with an average age of 58.8 years. The duration of internal fixation averaged 14.5 months. We investigated the efficacy of the tendon irritation test to elicit a sign of tendon irritation before hardware removal, and we intraoperatively evaluated the presence of FPL tendon injuries. RESULTS: Twenty-four of 30 wrists exhibited a sign of tendon irritation. There was no statistical correlation between a sign of tendon irritation and patient age or the duration of internal fixation. We diagnosed 10 wrists with tenosynovitis and 8 frayed tendons. The sensitivity of the tendon irritation test to identify a sign of tendon irritation that was associated with FPL tendon injuries was 80.0%, and its specificity to correctly identify non-injured FPL tendons was 40.0%. The duration of internal fixation associated with tendon fraying was significantly longer than it was in cases of non-injured tendons and tenosynovitis. CONCLUSION: Our results suggest that subsequent examinations should be performed when the tendon irritation test is positive for signs of tendon irritation that may require plate removal.


Assuntos
Placas Ósseas , Fixação Interna de Fraturas/métodos , Fraturas do Rádio/cirurgia , Traumatismos dos Tendões/prevenção & controle , Adulto , Idoso , Idoso de 80 Anos ou mais , Placas Ósseas/efeitos adversos , Feminino , Fixação Interna de Fraturas/efeitos adversos , Fixação Interna de Fraturas/instrumentação , Humanos , Masculino , Pessoa de Meia-Idade , Fraturas do Rádio/complicações , Medição de Risco/métodos , Fatores de Risco , Ruptura/etiologia , Ruptura/prevenção & controle , Traumatismos dos Tendões/etiologia , Tendões/fisiopatologia , Adulto Jovem
20.
J Plast Reconstr Aesthet Surg ; 66(6): 864-6, 2013 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-23182345

RESUMO

We report a case of keloid formation on the palm of the hand after trigger finger release. A 58-year-old male with trigger finger of the right index, middle and ring fingers was treated with open release at a nearby hospital. Three months after this operation, a progressively enlarging skin lesion formed at the surgical site. A diagnosis was made of keloid formation after trigger finger release, and keloid excision with full thickness skin graft and postoperative radiation therapy was done. One year postoperatively, the patient was asymptomatic and had not experienced a recurrence. This is a first report about keloid formation on the palm after trigger finger release. Our patient had a good outcome with keloid excision, full thickness skin graft and postoperative radiation therapy.


Assuntos
Queloide/cirurgia , Complicações Pós-Operatórias/cirurgia , Transplante de Pele/métodos , Dedo em Gatilho/cirurgia , Bandagens , Humanos , Queloide/etiologia , Masculino , Pessoa de Meia-Idade
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