The effect of concentrated growth factors in the treatment of periodontal intrabony defects.

AIM: To investigate the effect of concentrated growth factors (CGFs) in human intrabony defect treatment. METHODS: Thirty-one intrabony defects were randomly treated with CGFs + bovine porous bone mineral (BPBM) or BPBM alone. Probing depth, clinical attachment level and hard tissue fill were evaluated at baseline and 1 year post surgery. RESULTS: No differences in any of the investigated parameters were observed at baseline. At 1 year post therapy, both groups showed significant improvement in clinical parameters (p < 0.001). CGFs + BPBM was more effective than BPBM alone at decreasing probing depth (4.2 ± 1.3 mm vs 3.0 ± 1.6 mm) and clinical attachment level gain (3.7 ± 1.3 mm vs 2.4 ± 1.1 mm; p ≤ 0.05). A favorable increase of hard tissue fill was noted in CGFs + BPBM group compared with BPBM group (p > 0.05). The contents of growth factors in CGFs were statistically higher than those in platelet poor plasma (p < 0.001). CONCLUSION: Addition of CGFs significantly improved clinical effectiveness of BPBM for intrabony defect treatment.

[Effect of regenerative therapy for the furcation involvements of mandibular molars evaluated by cone-beam computed tomography].

OBJECTIVE: To evaluate the effect of regenerative therapy for the treatment of furcation involvements of mandibular molars with cone-beam computed tomography (CBCT). METHODS: In the study, 38 furcation involvements of mandibular molars were included and randomly divided into two groups. The experimental group accepted guided tissue regeneration and bone graft therapy, and the control group only flap surgery. The clinical examination and CBCT examination were performed at baseline and 1 year post-surgery. RESULTS: The clinical and CBCT data of both groups were not statistically different at baseline (P>0.05). At the end of 1 year post-surgery, except gingival recession, the clinical parameters of both groups were significantly improved (P<0.001). The vertical and horizontal attachment gains of the experimental group were (3.20 ± 1.82) mm and (2.05 ± 1.27) mm, respectively, and significantly higher than the changes of the control group (P<0.001). And at the end of 1 year post-surgery, the experimental group showed significantly higher bone gain at the vertical and horizontal directions compared with those of the control group: (2.82 ± 0.97) mm and (2.24 ± 0.92) mm, respectively (P<0.001). CONCLUSION: With the limitation of this study, the effect of guided tissue regeneration surgery and bone graft therapy for the treatment of furcation involvements of mandibular molars is significantly better than that of the flap surgery. CBCT can reflect the horizontal and vertical bone changes of furcation area, which is more comprehensive than traditional periapicals.

The accuracy of cone-beam computed tomography in assessing maxillary molar furcation involvement.

AIM: The aim of this study was to investigate the accuracy of cone-beam computed tomography (CBCT) in assessing maxillary molar furcation involvement (FI). MATERIALS AND METHODS: Fifteen patients with generalized chronic periodontitis after initial therapy were recruited. CBCT was performed in maxillary molars with probing pocket depths of ≥6 mm and advanced FI, and CBCT images were analysed. Furcation surgery was performed in 20 maxillary molars. Lastly, intra-surgical FI assessments were compared with CBCT-based data. RESULTS: Intra-surgical findings confirmed 82.4% of the CBCT data, with a weighted kappa of 0.917. The agreement between both assessments was the highest in buccal furcation entrances, followed by distopalatal and mesiopalatal furcation entrances. Of the four parameters tested of detailed root anatomy and furcation morphology, the mean length of the root trunk and the width of the furcation entrance revealed by CBCT were consistent with their respective intra-surgical values (p > 0.05). Horizontal bone loss and vertical bone loss were underestimated by CBCT relative to their respective intra-surgical classifications (p ≤ 0.05). CONCLUSIONS: Cone-beam computed tomography images demonstrate a high accuracy in assessing the loss of periodontal tissue of the FI and root morphologies in maxillary molars.

[The effects of indomethcin rinse on the periodontal inflammation].

OBJECTIVE: To observe the clinical results and the changes of gingival crevicular fluid prostaglandins E(2) (GCF-PGE(2)) levels three months after indomethcin rinsing. METHODS: Nineteen periodontal patients who had received periodontal treatment before were chosen and divided into two groups randomly: indomethcin test group and placebo control group. The clinical parameters and gingival crevicular fluid (GCF) samples were obtained respectively at 0, 1, 3 month. The levels of GCF-PGE(2) were measured by radioimmunoassay (RIA). RESULTS: After 3 months' rinse treatment, the bleeding index and the amounts of GCF in test group decreased significantly than those of the control group. Attachment level improved in test group as well. The levels of GCF-PGE(2) significantly decreased in test group, which not changed in control group. The percentage value of plaque reduced considerably in both test group and control group after rinsing, but no significant difference was found between these two groups. CONCLUSION: Gingival inflammation and the levels of GCF-PGE(2) are reduced after topical indomethcin administration. The effect is related to the decrease of local PGE(2) levels.