Enhancement of the photoacoustic effect during the light-particle interaction.

Exogenous photoacoustic contrast agents such as gold nanoparticles are widely utilized in photoacoustic imaging. Enhancing the photoacoustic performance of gold nanoparticles is pivotal for improving the quality and expanding the application scope of photoacoustic imaging. In this work, the photothermal and photoacoustic responses of gold nanospheres surrounded by water excited with a pulsed laser are obtained via a two-temperature model. The interplay between pulse duration and interface thermal resistance and its effect on the photothermal and photoacoustic performances are uncovered quantitatively. The results reveal that, as the pulse duration decreases, increasing the interfacial thermal conductivity can substantially enhance heat transfer between the gold nanosphere and the surrounding water. However, this approach does not effectively enhance the photoacoustic performance. Interestingly, when increasing the thermal conductivity, it was found that there is an optimal pulse duration within the range of 10 ps-10 ns. Employing an incident pulse laser with this optimal pulse duration can maximize the enhancement of the photoacoustic signal.

Nomogram for predicting the risk of nonalcoholic fatty liver disease in older adults in Qingdao, China: A cross-sectional study.

BACKGROUND AND OBJECTIVES: To explore the risk factors for non-alcoholic fatty liver disease (NAFLD) and to establish a non-invasive tool for the screening of NAFLD in an older adult population. METHODS AND STUDY DESIGN: A total of 131,161 participants were included in this cross-sectional study. Participants were randomly divided into training and validation sets (7:3). The least absolute shrinkage and selection operator method was used to screen risk factors. Multivariate logistic regression was employed to develop a nomogram, which was made available online. Receiver operating characteristic curve analysis, calibration plots, and decision curve analysis were used to validate the discrimination, calibration, and clinical practicability of the nomogram. Sex and age subgroup analyses were conducted to further validate the reliability of the model. RESULTS: Nine variables were identified for inclusion in the nomogram (age, sex, waist circumference, body mass index, exercise frequency, systolic blood pressure, fasting plasma glucose, alanine aminotransferase, and low-density lipoprotein cholesterol). The area under the receiver operating characteristic curve values were 0.793 and 0.790 for the training set and the validation set, respectively. The calibration plots and decision curve analyses showed good calibration and clinical utility. Subgroup analyses demonstrated consistent discriminatory ability in different sex and age subgroups. CONCLUSIONS: This study established and validated a new nomogram model for evaluating the risk of NAFLD among older adults. The nomogram had good discriminatory performance and is a non-invasive and convenient tool for the screening of NAFLD in older adults.

Decreased levels of hydrogen sulfide in the hypothalamic paraventricular nucleus contribute to sympathetic hyperactivity induced by cerebral infarction.

Paroxysmal sympathetic hyperactivity (PSH) is a common clinical feature secondary to ischemic stroke (IS), but its mechanism is poorly understood. We aimed to investigate the role of H2S in the pathogenesis of PSH. IS patients were divided into malignant (MCI) and non-malignant cerebral infarction (NMCI) group. IS in rats was induced by the right middle cerebral artery occlusion (MCAO). H2S donor (NaHS) or inhibitor (aminooxy-acetic acid, AOAA) were microinjected into the hypothalamic paraventricular nucleus (PVN). Compared with the NMCI group, patients in the MCI group showed PSH, including tachycardia, hypertension, and more plasma norepinephrine (NE) that was positively correlated with levels of creatine kinase, glutamate transaminase, and creatinine respectively. The 1-year survival rate of patients with high plasma NE levels was lower. The hypothalamus of rats with MCAO showed increased activity, especially in the PVN region. The levels of H2S in PVN of the rats with MCAO were reduced, while the blood pressure and renal sympathetic discharge were increased, which could be ameliorated by NaHS and exacerbated by AOAA. NaHS completely reduced the disulfide bond of NMDAR1 in PC12 cells. The inhibition of NMDAR by MK-801 microinjected in PVN of rats with MCAO also could lower blood pressure and renal sympathetic discharge. In conclusion, PSH may be associated with disease progression and survival in patients with IS. Decreased levels of H2S in PVN were involved in regulating sympathetic efferent activity after cerebral infarction. Our results might provide a new strategy and target for the prevention and treatment of PSH.

Research on modification and noise reduction optimization of Electric Multiple Units traction gear under multiple working conditions.

The vibration and radiation noise characteristics of the gear transmission system are different under different traction conditions, and the gear modification optimization scheme based on a single working condition is not suitable for the operating environment under all working conditions. To modify the traction gear of a high-speed EMU, an optimized design scheme for noise reduction under multiple working conditions is proposed. A modification plan of the tooth direction in conjunction with the tooth shape was devised using a parametric model of the EMU's traction gear transmission system. The radiation noise of the gear transmission system after modification was solved using the acoustic boundary element method under different working conditions. A gear noise prediction model based on the random forest was proposed, and a gear modification parameter combination was constructed to minimize radiation noise. Then, the optimal design scheme of multi-condition modification combination parameters is obtained with the weight of the running time and acoustic contribution under different working conditions. The grey correlation degree evaluation model is established to verify that the multi-condition modification optimization design method can make the traction gear of EMU obtain satisfactory transmission performance and noise reduction effect under different working conditions.

Possible quantum-spin-liquid state in van der Waals cluster magnet Nb3Cl8.

The cluster magnet Nb3Cl8consists of Nb3trimmers that form an emergentS= 1/2 two-dimensional triangular layers, which are bonded by weak van der Waals interactions. Recent studies show that its room-temperature electronic state can be well described as a single-band Mott insulator. However, the magnetic ground state is non-magnetic due to a structural transition below about 100 K. Here we show that there exists a thickness threshold below which the structural transition will not happen. For a bulk crystal, a small fraction of the sample maintains the high-temperature structure at low temperatures and such remnant gives rise to linear-temperature dependence of the specific heat at very low temperatures. This is further confirmed by the measurements on ground powder sample orc-axis pressed single crystals, which prohibits the formation of the non-magnetic state. Moreover, the intrinsic magnetic susceptibility also tends to be constant with decreasing temperature. Our results suggest that Nb3Cl8with the high-temperature structure may host a quantum-spin-liquid ground state with spinon Fermi surfaces, which can be achieved by making the thickness of a sample smaller than a certain threshold.

3D-Printed Carbon-Based Conformal Electromagnetic Interference Shielding Module for Integrated Electronics.

Electromagnetic interference shielding (EMI SE) modules are the core component of modern electronics. However, the traditional metal-based SE modules always take up indispensable three-dimensional space inside electronics, posing a major obstacle to the integration of electronics. The innovation of integrating 3D-printed conformal shielding (c-SE) modules with packaging materials onto core electronics offers infinite possibilities to satisfy ideal SE function without occupying additional space. Herein, the 3D printable carbon-based inks with various proportions of graphene and carbon nanotube nanoparticles are well-formulated by manipulating their rheological peculiarity. Accordingly, the free-constructed architectures with arbitrarily-customized structure and multifunctionality are created via 3D printing. In particular, the SE performance of 3D-printed frame is up to 61.4 dB, simultaneously accompanied with an ultralight architecture of 0.076 g cm-3 and a superhigh specific shielding of 802.4 dB cm3 g-1. Moreover, as a proof-of-concept, the 3D-printed c-SE module is in situ integrated into core electronics, successfully replacing the traditional metal-based module to afford multiple functions for electromagnetic compatibility and thermal dissipation. Thus, this scientific innovation completely makes up the blank for assembling carbon-based c-SE modules and sheds a brilliant light on developing the next generation of high-performance shielding materials with arbitrarily-customized structure for integrated electronics.

Plasma Cytokine Expression and Immune Reconstitution in Early and Delayed Anti-HIV 96-Weeks Treatment: A Retrospective Study.

HIV is an immunodeficiency disease with emergence of inadequate corresponding reconstruction therapies. Pyroptosis of CD4+T cell is mainly caused by immune activation and inflammation that cannot be reduced by successful antiretroviral therapy (ART) alone. Coinfections because of CD4+T cell reconstitution failure can occur. Anti-inflammatory treatment determines the success of immune reconstitution. In our experiment, only a few cytokines could recover to normal level following a 2-year antiretroviral treatment in early ART initiation, which is consistent with current findings about adjuvant HIV anti-inflammatory therapy. Early infection is often accompanied by a more severe inflammatory response. Innate immunity cytokines like granulocyte macrophage-colony stimulating factor, IFN-γ induced protein 10 kDa, and tumor necrosis factor-α exhibited the most elevated levels among all kinds of inflammatory cytokines. The correlation analysis showed at least eight cytokines contributing to the changes of CD4/CD8 ratio.

Assembling all-wood-derived carbon/carbon dots-assisted phase change materials for high-efficiency thermal-energy harvesters.

The collection and storage of renewable, sustainable and clean energy including wind, solar, and tidal energy has attracted considerable attention because of its promising potential to replace fossil energy sources. Advanced energy-storage materials are the core component for energy harvesters, affording the high-efficiency conversion of these new-style energy sources. Herein, originated from nature, a series of all-wood-derived carbon-assisted phase change materials (PCMs) were purposed by incorporating carbon dots-modified polyethylene glycol matrix into carbon skeletons via a vacuum-impregnation strategy. The resultant PCMs possessed desired anti-leakage capability and superior thermophysical behaviors. In particular, the optimum sample posed high latent heat (131.5 J/g) and well thermal stability, where the corresponding enthalpy still reserved 90 % over 100 heating/cooling cycles. More importantly, the as-fabricated thermal-energy harvester presented prominent capability to strorage and release multiple forms of thermal energy, as well as high-efficiency solar-energy utilization, corresponding to a photothermal conversion efficiency of 88 % in simulated sunlight irradiation, far exceeding some reported PCMs. Overall, with the introduction of wood-derived carbon dots and carbon skeletons, the assembled all-wood-derived carbon-assisted PCMs afforded trinity advantages on thermal performance, cycling stability, and energy conversion efficiency, which provide a promising potential for the practical application in thermal-energy harvesters.

[Retracted] Resveratrol reduces acute lung injury in a LPS­induced sepsis mouse model via activation of Sirt1.

Following the publication of this paper, it was drawn to the Editor's attention by a concerned reader that the ß­actin control western blotting data shown in Fig. 3D on p. 1893 were very similar to the contol data shown in Fig. 4A on p. 1894; furthermore, the data shown for the MMP­9 and the INOS protein bands in Fig. 4C were remarkably similar to the data shown for the IL­1ß and IL­6 proteins, respectively, albeit the backgrounds surrounding the bands were different. Moreover, various of the western blotting data shown in these figures were strikingly similar to data that had already been published in different form in other articles written by (largely) different authors at different research institutes. Owing to the fact that the contentious data in the above article had already been published prior to its submission to Molecular Medicine Reports, and due to the number of apparent duplications of strikingly similar data between Figs. 3 and 4, the Editor has decided that this paper should be retracted from the Journal. The authors were asked for an explanation to account for these concerns, but the Editorial Office did not receive a satisfactory reply. The Editor apologizes to the readership for any inconvenience caused. [Molecular Medicine Reports 7: 1889­1895, 2013; DOI: 10.3892/mmr.2013.1444].

Simulation of carbon peaking process of high energy consuming manufacturing industry in Shaanxi Province: A hybrid model based on LMDI and TentSSA-ENN.

To achieve the goals of carbon peaking and carbon neutrality in Shaanxi, the high energy consuming manufacturing industry (HMI), as an important contributor, is a key link and important channel for energy conservation. In this paper, the logarithmic mean Divisia index (LMDI) method is applied to determine the driving factors of carbon emissions from the aspects of economy, energy and society, and the contribution of these factors was analyzed. Meanwhile, the improved sparrow search algorithm is used to optimize Elman neural network (ENN) to construct a new hybrid prediction model. Finally, three different development scenarios are designed using scenario analysis method to explore the potential of HMI in Shaanxi Province to achieve carbon peak in the future. The results show that: (1) The biggest promoting factor is industrial structure, and the biggest inhibiting factor is energy intensity among the drivers of carbon emissions, which are analyzed effectively in HMI using the LMDI method. (2) Compared with other neural network models, the proposed hybrid prediction model has higher accuracy and better stability in predicting industrial carbon emissions, it is more suitable for simulating the carbon peaking process of HMI. (3) Only in the coordinated development scenario, the HMI in Shaanxi is likely to achieve the carbon peak in 2030, and the carbon emission curve of the other two scenarios has not reached the peak. Then, according to the results of scenario analysis, specific and evaluable suggestions on carbon emission reduction for HMI in Shaanxi are put forward, such as optimizing energy and industrial structure and making full use of innovative resources of Shaanxi characteristic units.

During the Omicron Pandemic Wave, the Severe Systemic Inflammatory Status of COVID-19 Indicated a Higher Risk of In-Hospital Mortality and Mediated the Clinical Efficacy of Corticosteroids.

Background: For the distinct immune/inflammatory responses from Omicron variant infection, this study aimed to investigate the diagnostic efficacy of systemic inflammatory indicators and the clinical efficacy of corticosteroids on the in-hospital mortality among COVID-19 patients. Methods: Under a retrospective cohort study, 1081 COVID-19 patients were recruited from Beijing Youan Hospital, Capital Medical University between November 16, 2022 and January 30, 2023. We chose neutrophil-to-lymphocyte ratio (NLR), CRP-to-lymphocyte ratio (CLR), and CRP-to-albumin ratio (CAR) as the systemic inflammatory indicators. Receiver operating curve (ROC) and multivariate logistic regression analysis were used to determine the diagnostic efficacy of systemic inflammatory indicators and the association between systemic inflammatory indicators and in-hospital mortality. Results: Among 684 patients included in analysis, 96 died during hospitalization. NLR, CLR and CAR performed well (with an area under the curve (AUC) greater than 0.75) in discriminating in-hospital mortality among COVID-19 patients. The severe status of systemic inflammation, with optimal cut-off value derived from ROC analysis, significantly associated higher risk of in-hospital mortality (OR = 3.81 for NLR ≥ 6.131; OR = 3.76 for CLR ≥ 45.455; OR = 5.10 for CAR ≥ 1.436). Corticosteroids use within 72 hours of admission increased the in-hospital mortality 2.88-fold for COVID-19 patients. In the subgroup of patients with severe systemic inflammation, corticosteroids increased the risk of in-hospital mortality (OR = 2.11 for NLR, p = 0.055; OR = 2.94 for CLR, p = 0.005; OR = 2.31 for CAR, p = 0.036). Conclusion: Systemic inflammatory indicators had good diagnostic performance for in-hospital mortality. Patients with severe systemic inflammatory status should not receive corticosteroid treatment and further studies are warranted for confirmation.

A novel tumor immunotherapy-related signature for risk stratification, prognosis prediction, and immune status in hepatocellular carcinoma.

Immunotherapy as a strategy to deal with cancer is increasingly being used clinically, especially in hepatocellular carcinoma (HCC). We aim to create an immunotherapy-related signature that can play a role in predicting HCC patients' survival and therapeutic outcomes. Immunotherapy-related genes were discovered first. Clinical information and gene expression data were extracted from GSE140901. By a series of bioinformatics methods to analyze, overlapping genes were used to build an immunotherapy-related signature that could contribute to predict both the prognosis of people with hepatocellular carcinoma and responder to immune checkpoint blockade therapy of them in TCGA database. Differences of the two groups in immune cell subpopulations were then compared. Furthermore, A nomogram was constructed, based on the immunotherapy-related signature and clinicopathological features, and proved to be highly predictive. Finally, immunohistochemistry assays were performed in HCC tissue and normal tissue adjacent tumors to verify the differences of the four genes expression. As a result of this study, a prognostic protein profile associated with immunotherapy had been created, which could be applied to predict patients' response to immunotherapy and may provide a new perspective as clinicians focus on non-apoptotic treatment for patients with HCC.

Association between CD10 expression and phyllodes tumor: A retrospective case control study.

The present study aimed to explore the association between immunohistochemical markers and phyllodes tumor (PT). The retrospective case control study included biopsies from patients with PT who underwent surgical treatment, and patients with fibronenoma (FA), diagnosed in our hospital from October 2014 to May 2021. Differences in microscopic histopathological characteristics and expressions of common immunohistochemical markers (CD10, cluster of differentiation 117 marker, cluster of differentiation 34 marker, tumor protein P53, cell proliferation antigen) for different grades of PT and FA were analyzed. A total of 69 patients were enrolled, of them 34 with PT (12 with benign PT, 13 with borderline PT, and 9 with malignant PT) and 35 with FA. With the increase of tumor malignancy, significant enlargement trend was noted; for FA, most tumor boundaries were well-defined, the stromal distribution was homogeneous, the stromal cellularity was small. In contrast for PT, as the degree of malignancy increased, tumor boundary gradually became ill-defined and the stromal distribution was heterogeneous; stromal cellularity and stromal overgrowth had increased significantly (All P < .05). Multivariate analysis showed that among other markers only CD10 expression (OR = 0.67, 95%CI: -0.88, 2.22, P < .05) was independently associated with PT. The study showed that in addition to histological features, CD10 expression was independently associated with PT and has a potential to be used as a differentiation marker.

Dynamic Changes of Cytokine Profiles and Their Correlation With Tumor Recurrence Following Thermal Ablation in Hepatocellular Carcinoma.

The 5-year recurrence rate of thermal ablation for hepatocellular carcinoma (HCC) is high, and whether this treatment strategy induces systemic immune response remains elusive. This study aimed to investigate the effects of thermal ablation on HCC patients' cytokine profiles and to explore the correlation of cytokine profiles with tumor recurrence after ablation. A total of 22 HCC patients were included in this prospective study. The levels of 27 cytokines in the peripheral blood of HCC patients were measured before ablation (baseline), week 1, and week 4 after ablation using a Bio-Plex Pro Human Cytokine 27-plex Assay kit. Cytokines showed different dynamic changing trends after ablation treatment. It was found that the level of IL-6 was significantly elevated at week 1 and returned to the baseline level at week 4 after ablation. The level of IL-10 was slightly reduced at week 1 and significantly decreased at week 4. The levels of MCP-1, macrophage inflammatory protein-1ß (MIP-1ß), and TNF-α were similarly reduced at week 1 and increased at week 4. The levels of IL-17, platelet-derived growth factor-BB (PDGF-BB), and regulated upon activation, normal T cell expressed and secreted (RANTES) showed little to no change at week 1 while an observable increase at week 4. Patients with a high IL-10 level (2.99 pg/ml) at baseline and low levels of TNF-α (20.4 pg/ml), PDGF-BB (107.78 pg/ml), and RANTES (2303.94 pg/ml) at week 4 were at risk of tumor recurrence during 1-year follow-up. The results suggested that thermal ablation activated systemic immune responses by changing the levels of cytokines. The results also demonstrated that measurement of IL-10 at baseline, TNF-α, PDGF-BB, and RANTES at week 4 after ablation might predict the risk of tumor recurrence.

Asymmetric warming reduces the strength of selection pressure of moderate grazing on reproductive phenology in alpine plants.

Both warming and grazing already affect the reproductive phenology of alpine plants. However, their effects have mostly been studied in isolation, and their interaction is still unclear. In this study, an asymmetric warming (average + 1.2 °C during daytime and + 1.7 °C during nighttime and + 1.5 °C during summer and + 2.0 °C during winter) with moderate grazing experiment was conducted for four years to determine their individual and interactive effects on the onsets and durations of reproductive phenophases for fifteen alpine plant species on the Qinghai-Tibetan Plateau. Individual warming and grazing simultaneously advanced the average start dates and ending dates of budding, flowering and fruiting by 5.3-6.2 days, and further resulted in smaller effects on their durations for most plant species. The interactions between warming and grazing on them varied with plant species and year, which advanced by average 12.1 days for all plant species. The effects of grazing on the temperature sensitivity of the start dates of reproductive phenophases (average by -8.5 days °C-1) were greater than that of warming alone (average by -3.4 days °C-1) and warming with grazing (average by -5.5 days °C-1) for most of the alpine plant species. There were significant effects of the previous phenological events on subsequent reproductive phenophases. Therefore, our results suggested that both warming and grazing advanced reproductive phenophases through altered soil temperature and soil moisture and carry-over effects of previous phenological events on subsequent phenological events. Warming reduced the temperature sensitivity of the start dates of reproductive phenophases to grazing, suggesting that it depressed strength of selection pressure of grazing on the onsets of reproductive phenology in alpine plants.

3D printing of ultralight MWCNT@OCNF porous scaffolds for high-efficiency electromagnetic interference shielding.

Towards the difficulties of traditional processing technology in loading high-concentration functional fillers to realize the target electromagnetic interference shielding (EMI SE) performance, and constructing the arbitrary-designated architectures for serving advanced electronics, this work innovatively formulated a functional multi-walled carbon nanotubes@cellulose nanofibers (MWCNT@OCNF) ink for direct ink writing (DIW) 3D printing, which not only possessed high freedom on the proportion of functional particles, but also imparted to the ideal rheological performance for 3D printing. Based on the pre-programmed printing trajectories, a series of porous scaffolds featuring exceptional functionalities were architected. Particularly for the electromagnetic waves (EMWs) shielding behaviors, the optimized one with "full-mismatched" architecture posed the ultralight structure (0.11 g/cm3) and superior SE performance (43.5 dB) in the X-band frequency region. More encouragingly, the 3D-printed scaffold with hierarchical pores possessed the ideal electromagnetic compatibility on EMWs signal, where the radiation intensity generated by EMWs signal fluctuated in a step pattern in 0 and 1500 µT/cm2 as loading and unloading scaffolds. Overall, this study paved a novel path for the formulation of functional inks to print lightweight, multi-structure, and high-efficiency EMI SE scaffolds for the next-generation shielding elements.

Spatiotemporal variation and influencing factors of air pollution in Anhui Province.

Anhui Province locates in the Yangtze River Delta region. The spatial difference between the north and the south is significant, and the air quality is improved over time. Studying the spatial and temporal changes of air pollution and its influencing factors for the coordinated control of air pollutants in the Yangtze River Delta region is significant. This study used the annual and monthly average data of six pollutants, PM2.5, PM10, O3, NO2, SO2, and CO, in Anhui Province and various cities from 2015 to 2021 and analyzed the spatiotemporal change characteristics using Excel and GIS software. Meanwhile, this paper used the SPSS correlation analysis method to analyze the correlation between pollutants and meteorological factors and analyzed the impact of economic development and environmental protection policies. The results are shown below. (1) The concentrations of SO2, NO2, and CO showed an overall downward trend at an interannual level. Meanwhile, the concentrations of PM10 and PM2.5 first increased slowly before 2017 and then declined, while the concentrations of O3 increased significantly before 2018 and then declined slowly. On a monthly scale, O3 presented an M-shaped change, while the other five pollutants basically presented a U-shaped change mode. The top monthly pollutants in each city followed the order of PM2.5, O3, PM10, and NO2. (2) PM2.5 and PM10 showed apparent characteristics of high concentrations in the north and low concentrations in the south in space. There were no significant differences in NO2, SO2, and CO pollution between the north and the south in space, and the differences in spatial pollution among cities were reduced significantly. (3) Five pollutants (SO2, NO2, PM10, PM2.5, and CO) except O3 were positively correlated, and the degree of correlation was correlated, strongly correlated, and above. However, five pollutants were negatively correlated with O3. The temperature had the most significant impact of negative correlation on five pollutants except for O3. The sunshine duration had the most significant impact on O3. (4) Economic growth and environmental protection policies in Anhui Province have positively affected environmental governance.

Preparation and characterization of superior hydrophilic PVDF/DA membranes by the self-polymerization approach of dopamine.

Polyvinylidene fluoride (PVDF) membranes are favored for their excellent properties. However, the inherent strong hydrophobicity of PVDF membranes limits their development in the field of water treatment. The objective of this study was to improve the performance of PVDF membranes using the self-polymerization, strong adhesion properties, and biocompatible effects of dopamine (DA). The PVDF/DA membrane modification conditions were simulated and optimized using response surface methodology (RSM), and the experimental design was used to investigate three main parameters. The results showed that the DA solution concentration of 1.65 g/L, the coating time of 4.5 h, the post-treatment temperature of 25°C, the contact angle decreased from 69° to 33.9°, and the pure water flux on the PVDF/DA membrane was higher than that on the original membrane. The absolute value of the relative error between the actual and predicted values is only 3.36 %. In the MBR parallel comparison test, compared with the PVDF/DA membrane, the total amount of extracellular polymers (EPS) of the PVDF membrane increased by 1.46 times and the polysaccharide increased by 1.56 times, which further showed that the PVDF/DA modified membrane had the excellent anti-pollution ability. Through Alpha diversity analysis, the biodiversity detected on PVDF/DA membranes was higher than that of PVDF membranes, which further proved its good bio-adhesion ability. These findings could offer a reference for the hydrophilicity, antifouling, and stability of PVDF/DA membranes, which would establish the foundation for the comprehensive applications in MBR.

Association between serum uric acid levels and clinical outcomes in patients with acute kidney injury.

BACKGROUND: The effects of serum uric acid (SUA) on clinical outcomes in patients with acute kidney injury (AKI) are unclear. The aim of this study was to investigate the association of SUA levels with clinical outcomes of AKI patients. METHODS: The data of AKI patients hospitalized in the Affiliated Hospital of Qingdao University were retrospectively reviewed. Multivariable logistic regression was utilized to assess the association between SUA levels and the clinical outcomes of AKI patients. Receiver operating characteristic (ROC) analysis was applied to assess the predictive ability of SUA levels for in-hospital mortality in patients with AKI. RESULTS: A total of 4,646 AKI patients were eligible for study inclusion. In multivariable analysis, after adjustment for various confounding factors in the fully adjusted model, a higher SUA level was found to be associated with increased in-hospital mortality of AKI patients with an odds ratio (OR) of 1.72 (95% CI, 1.21-2.33, p = 0.005) for the SUA level >5.1-6.9 mg/dl group and 2.75 (95% CI, 1.78-4.26, p < 0.001) for the SUA level >6.9 mg/dl group compared with the reference group (SUA ≤3.6 mg/dl). In the ROC analysis, the area under the curve (AUC) of SUA was 0.65 with a sensitivity of 51% and a specificity of 73%. CONCLUSIONS: An elevated SUA level is associated with an increased risk of in-hospital mortality in patients with AKI, and it appears to be an independent prognostic marker for these patients.

Bleaching-free, lignin-tolerant, high-yield production of nanocrystalline cellulose from lignocellulosic biomass.

Nanocrystalline cellulose (NCC) preparation in an integrated fractionation manner is expected to solve the problems of low yield and environmental impact in the traditional process. An integrated fractionation strategy for NCC production from wood was developed through catalytic biomass fractionation, the partial dissolution of cellulose-rich materials (CRMs) in aqueous tetrabutylphosphonium hydroxide, and short-term ultrasonication. The presented process could tolerate a high CRM lignin content of 21.2 wt % and provide a high NCC yield of 76.6 wt % (34.3 wt % of the original biomass). The increase in the CRM lignin content decreased the NCC yield, facilitated the crystal transition of NCC from cellulose I to cellulose II, and showed no apparent effects on the NCC morphology. A partial/selective dissolution mechanism is proposed for the presented strategy. This study provided a promising efficient fractionation-based method toward comprehensive and high-value utilization of lignocellulosic biomass through effective delignification and high-yield NCC production.