Magnetocardiography-based coronary artery disease severity assessment and localization using spatiotemporal features.

Objective.This study aimed to develop an automatic and accurate method for severity assessment and localization of coronary artery disease (CAD) based on an optically pumped magnetometer magnetocardiography (MCG) system.Approach.We proposed spatiotemporal features based on the MCG one-dimensional signals, including amplitude, correlation, local binary pattern, and shape features. To estimate the severity of CAD, we classified the stenosis as absence or mild, moderate, or severe cases and extracted a subset of features suitable for assessment. To localize CAD, we classified CAD groups according to the location of the stenosis, including the left anterior descending artery (LAD), left circumflex artery (LCX), and right coronary artery (RCA), and separately extracted a subset of features suitable for determining the three CAD locations.Main results.For CAD severity assessment, a support vector machine (SVM) achieved the best result, with an accuracy of 75.1%, precision of 73.9%, sensitivity of 67.0%, specificity of 88.8%, F1-score of 69.8%, and area under the curve of 0.876. The highest accuracy and corresponding model for determining locations LAD, LCX, and RCA were 94.3% for the SVM, 84.4% for a discriminant analysis model, and 84.9% for the discriminant analysis model.Significance. The developed method enables the implementation of an automated system for severity assessment and localization of CAD. The amplitude and correlation features were key factors for severity assessment and localization. The proposed machine learning method can provide clinicians with an automatic and accurate diagnostic tool for interpreting MCG data related to CAD, possibly promoting clinical acceptance.

Magnetocardiography using optically pumped magnetometers array to detect acute myocardial infarction and premature ventricular contractions in dogs.

Objective. Optically pumped magnetometers (OPMs) are recently developed magnetocardiography (MCG) sensors that can detect cardiac diseases. This is of great clinical significance for detecting acute myocardial infarction (AMI) and premature ventricular contractions (PVC). This study investigates the use of an array of OPMs to detect heart disease in animals.Approach.An array of OPMs was used to detect the MCG of AMI and PVC in dogs. We used four dogs in this study, and models of AMI with different degrees of severity were established by ligating the middle and proximal segments of the left anterior descending coronary artery. The dogs had PVC at the time of AMI. Continuous MCG time series with corresponding electrocardiograms (ECGs) and average MCG for each dog in different states are presented. The MCG features were extracted from the MCG butterfly diagram, magnetic field map, and pseudo current density map. The MCG features were used to quantify and compare with the gold-standard ECG measures.Main results.The results show that MCG features can accurately distinguish different states of dogs. That is, an array of OPMs can effectively detect AMI and PVC in dogs.Significance.We conclude that the array of OPMs can detect heart diseases in animals. Moreover, OPMs can complement or even replace superconducting quantum interference devices for MCG measurement in animals and diagnosis of human heart diseases in the future.

Test and Analysis of High-Permeability Material's Microstructure in Magnetic Shielding Device.

The magnetic shielding device is used to provide an extreme weak magnetic field, which plays a key role in variety of fields. Since the high-permeability material constituting the magnetic shielding device determines the magnetic shielding performance, it is important to evaluate the property of the high-permeability material. In this paper, the relationship between the microstructure and the magnetic properties of the high-permeability material is analyzed using minimum free energy principle based on magnetic domain theory, and the test method of the material's microstructure including the material composition, the texture and the grain structure to reflect the magnetic properties is put forward. The test result shows that the grain structure is closely related to the initial permeability and the coercivity, which is highly consistent with the theory. As a result, it provides a more efficient way to evaluate the property of the high-permeability material. The test method proposed in the paper has important significance in the high efficiency sampling inspection of the high-permeability material.

Measurement and Analysis of Magnetic Properties of Permalloy for Magnetic Shielding Devices under Different Temperature Environments.

The relative permeability, coercivity, and remanence of permalloy are closely related to the performance of magnetic shielding devices. In this paper, the relationship between the magnetic properties of permalloy and the working temperature of magnetic shielding devices is measured. Firstly, the measurement method of permalloy properties based on the simulated impact method is analyzed. What is more, a magnetic property test system consisting of a soft magnetic material tester and a high-low temperature chamber for permalloy ring samples at different temperatures was established to measure DC and AC (0.01 Hz to 1 kHz) magnetic properties at different temperatures (-60 °C to 140 °C). Finally, the results show that compared with room temperature (25 °C), the initial permeability (µi) decreases by 69.64% at -60 °C and increases by 38.23% at 140 °C, and the coercivity (hc) decreases by 34.81% at -60 °C and increases by 8.93% at 140 °C, which are the key parameters in the magnetic shielding device. It can be concluded that the relative permeability and remanence of permalloy are positively correlated with temperature, while the saturation magnetic flux density and coercivity are negatively correlated with temperature. This paper is of great significance to the magnetic analysis and design of magnetic shielding devices.

A Method to Measure Permeability of Permalloy in Extremely Weak Magnetic Field Based on Rayleigh Model.

In order to solve the problem that the relative permeability of the permalloy is missing and difficult to measure accurately in an extremely weak magnetic field (EWMF, <1 nT), a method to measure the permeability in EWMF based on the Rayleigh model is proposed in this paper. In this method, the Rayleigh model for the magnetic material was first introduced. Then, the test system for measuring the permeability of permalloy for the standard ring specimen was set up. Based on the test data and the Rayleigh model, the functional expression applied to obtain the permeability in EWMF is achieved. Finally, the feasibility and accuracy of the method are verified by the permeability measurement of the custom large-size ring specimen in EWMF (<1 nT) and residual field measurement based on the four-layer shielding cylinder. This method can obtain the relative permeability in any EWMF and avoid test errors caused by extremely weak magnetization signals.

Dynamic Stiffness Analysis and Measurement of Radial Active Magnetic Bearing in Magnetically Suspended Molecular Pump.

Current stiffness and displacement stiffness are two important parameters of radial active magnetic bearing (RAMB) that are generally considered as constants in a control system. However, such presumption may lead to the probable degradation of the control performance of the RAMB system when the perspective that the current and displacement stiffness should be variable due to variations in the speed. On this regard, a structure analysis and stiffness measurement method based on non-variable stiffness would not be feasible for RAMB under high-speed conditions. This paper presented an analysis of the dynamic stiffness characteristics of RAMB by means of a dynamic equivalent magnetic circuit method and laid out a comparison between the results of the theoretical analysis and the simulation results of finite element method. In particular, a novel dynamic stiffness measurement method of RAMB under high-rotation frequency was introduced. Results of experiments on the dynamic stiffness of RAMB demonstrated an excellent agreement with the theoretical research and the finite element analysis results, thereby verifying the rationality of the discussed dynamic stiffness characteristics. Practically, the proposed measurement method of RAMB dynamic stiffness provides an accurate analysis for the dynamic stiffness and contributes inspiring research significance for the dynamic properties of RAMB.

Study on PID tuning strategy based on dynamic stiffness for radial active magnetic bearing.

The development of industry technology requires magnetic bearings to work in high speed conditions. However, the current stiffness and displacement stiffness of the magnetic bearing will decrease significantly due to the consequent eddy current effect, and that decrease will make the system unstable and even result in the rotor drop and instrument damage. Therefore, the traditional Proportional-Integral-Derivative (PID) method based on constant stiffness is not adaptable for high speed conditions. This paper proposes a PID parameters tuning strategy based on dynamic stiffness for the radial active magnetic bearing (RAMB). The dynamic stiffness model under eddy current effect is established by analyzing the equivalent magnetic circuit model in which parameters are frequency-dependent. The PID parameters tuning method for RAMB control system including dynamic stiffness model is put forward according to the characteristic equation and Routh-Hurwitz criterion. Different PID parameters are set in simulations and several corresponding experiments are conducted. Satisfactory control effects consistent with the theoretical analysis are obtained and thus the proposed PID tuning strategy is verified to be good. Simulations and experiments in this paper provide theoretical guidance for the design of controller parameters and have research significance for structural optimization of RAMB.

A novel integrated structure with a radial displacement sensor and a permanent magnet biased radial magnetic bearing.

In this paper, a novel integrated structure is proposed in order to reduce the axial length of the high speed of a magnetically suspended motor (HSMSM) to ensure the maximum speed, which combines radial displacement sensor probes and the permanent magnet biased radial magnetic bearing in HSMSM. The sensor probes are integrated in the magnetic bearing, and the sensor preamplifiers are placed in the control system of the HSMSM, separate from the sensor probes. The proposed integrated structure can save space in HSMSMs, improve the working frequency, reduce the influence of temperature on the sensor circuit, and improve the stability of HSMSMs.

Selective activation of adrenergic beta1 receptors induces heme oxygenase 1 production in RAW264.7 cells.

We hypothesized that catecholamines through beta-adrenoceptor might modulate macrophage function. We showed that isoproterenol concentration-dependently induced HO-1 production through beta(1)-but not beta(2)-adrenoceptor. Production was increased by forskolin and inhibited by pretreatment with the PKA inhibitor, H-89. Furthermore, induction of HO-1 by isoproterenol effectively protected RAW264.7 cells from effects of glucose oxidase treatment, which was abrogated either by HO-1 inhibitor, ZnPP IX and beta-adenoceptor antagonist, propranolol. Thus, stimulation of HO-1 production through beta(1)-adenoceptors, and via the PKA pathways by isoproterenol, can enable RAW264.7 cells to resist oxidant stress, suggesting that catecholamine hormones may be necessary, at least, to maximize defending role of macrophages.