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OBJECTIVE: To compare the clinical efficacy and urodynamic parameter changes between the MiniArc and the Solyx sling for the treatment of female urodynamic stress incontinence (USI). MATERIALS AND METHODS: One-hundred and thirty (MiniArc n = 79, BS-Solyx n = 51) patients were included in this study. Cough stress test (ST), pad test (PT), Incontinence Impact short form Questionnaire (IIQ-7), Urogenital Distress Inventory six-item questionnaire (UDI-6), Sexual Questionnaire-Short Form (PIS-Q), and urodynamic parametric changes were assessed to determine objective and subjective outcomes following the procedure. Objective cure was defined as negative ST and PT <2 g and subjective cure was defined as "No" to the answer of UDI-6 Question #3. Predictors of surgical failure were also determined. RESULTS: All Solyx users, as opposed to 91.1% of MiniArc patients, obtained objective cure at postoperative 3 months (P = 0.042). No significant difference in subjective cure rates (93.7% vs. 90.2% at 3-months (P = 0.513); 89.9% vs. 80.4% at 1 year for Solyx and MiniArc patients, respectively (P = 0.126)) and improvement scores in UDI-6 and IIQ-7 were observed. The Solyx group incurred more de novo urgency (17.6% vs. 6.3% at 3 months (P = 0.042); 23.5% vs. 7.6% at 1 year (P = 0.01)). Both procedures yielded significant decrements in maximal urethral closure pressure (P < 0.001) and average flow rate (P = 0.015). The preoperative PT and sling type were strong predictors of surgical failure, where the Solyx tape reported lower odds (odds ratio = 0.174, P = 0.02) compared to the MiniArc sling. CONCLUSION: Single-incision mini-slings are safe and effective treatment for female USI. The Solyx SIS demonstrated superiority over the MiniArc in this study based on its higher objective cure rate and lower risk for surgical failure.
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Transvaginal mesh (TVM) insertion for the treatment of pelvic organ prolapse (POP) is significantly associated with lower failure rates, although its use remains controversial due to the potential risk of mesh-related complications. In this review, we collected the published literature regarding the use of TVM to treat POP in an attempt to assess both the efficacy and complications related to TVM usage in Taiwan. We searched 25 English language articles using PubMed related to TVM in Taiwan from 2010 to 2019. The present article focuses on the efficacy and complications of TVM and analyzes the data. There were 25 studies on TVM selected for this review. Regarding their success rate, 21 out of the 22 studies (95.5%) had more than a 90% objective success rate. Twenty studies (90.9%) had less than 10% major complications of TVM. Twenty out of the 25 studies (80.0%) had 5% or less mesh exposure. For self-cut TVM and the later single-incision TVM, both the complication rates and exposure rates decreased. The rate of de novo dyspareunia ranged from 2.6% to 14.3%, and the incidence decreased yearly from 2011 to 2019. This review showed both the high treatment efficacy and low complication rate of TVM usage for the short-term treatment of POP in Taiwan. However, a longer-term study is needed to draw a conclusion regarding the safety of this treatment.
Assuntos
Prolapso de Órgão Pélvico/cirurgia , Complicações Pós-Operatórias/epidemiologia , Slings Suburetrais/efeitos adversos , Telas Cirúrgicas/efeitos adversos , Vagina/cirurgia , Dispareunia/epidemiologia , Dispareunia/etiologia , Feminino , Humanos , Incidência , Pessoa de Meia-Idade , Complicações Pós-Operatórias/etiologia , Taiwan , Resultado do TratamentoRESUMO
OBJECTIVE: The alternations of mtDNA may play an important role in the molecular pathogenesis and process of Pelvic Organ Prolapse (POP) formation in both pre-menopausal and post-menopausal women. The aim of the present study is to analyze the association between the mitochondrial biogenesis gene and development of POP in the uterosacral ligaments (UL) of pre-menopausal women. MATERIALS AND METHODS: Seventy one pre-menopausal women, all below 52 years of age, were enrolled in this study. UL biopsies were obtained from uterine specimens taken from 33 women with POP (n = 33, study group) and 38 myoma patients without POP (n = 38, control group). Quantitative Real-Time PCR was performed to measure mitochondrial DNA (mtDNA) copy number and mtDNA4977. Western blotting and immunohistochemistry were used to assess the protein expression of PGC-1α, TFAM, NRF-1 and NRF-2. Statistical analysis was performed using SPSS statistical software and the Mann-Whitney U test, and the continuous variables were analyzed using the Student's t-test in demographic data. RESULTS: There were no significant differences in the patient demographics between the two groups (p > 0.05). The mtDNA copy number in the UL of pre-menopausal patients with prolapse was significantly higher than that in the no prolapse group (p = 0.008). There were no significant differences between the mtDNA4977 of the POP and non-POP groups, but a significantly higher expression of PGC-1α in the POP group compared to the non-POP group (1.59 ± 1.30 v.s. 0.66 ± 0.53; p = 0.036). The expression of TFAM in the POP group was higher than in the non-POP group). There was no significant difference in the TFAM(p = 0.377), NRF-1 and NRF-2 expression between the POP and non-POP groups (p = 0.647; p = 0.682). CONCLUSIONS: Changes in the PGC-1α and mtDNA copy number may play a role in the development of Pelvic Organ Prolapse in pre-menopausal patients.
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Variações do Número de Cópias de DNA , Regulação da Expressão Gênica , Prolapso de Órgão Pélvico/genética , Coativador 1-alfa do Receptor gama Ativado por Proliferador de Peroxissomo/genética , Pré-Menopausa/genética , Estudos de Coortes , DNA Mitocondrial/análise , Feminino , Humanos , Incidência , Pessoa de Meia-Idade , Prolapso de Órgão Pélvico/epidemiologia , Prolapso de Órgão Pélvico/fisiopatologia , Reação em Cadeia da Polimerase em Tempo Real/métodos , Estudos Retrospectivos , Estatísticas não ParamétricasRESUMO
OBJECTIVE: The study aimed to explore the changes in mitochondrial DNA (mtDNA) copy number, collagen, and matrix metalloproteinase (MMPs) expression with pelvic organ prolapse (POP) in the uterosacral ligaments of premenopausal women. MATERIALS AND METHODS: A group of 56 premenopausal women, all younger than 52 years of age, were enrolled in this study. Uterosacral ligament (UL) biopsies were obtained from uterine specimens taken from 22 women with POP (n = 22, study group) and 34 myoma patients without POP (n = 34, control group) during abdominal or vaginal hysterectomy. Quantitative real-time polymerase chain reaction (Q-PCR) and immunohistochemistry analysis were applied in the present study. RESULTS: The rate of high body mass index (BMI) (> 24 kg/m(2)) women was significantly higher in the POP group (81.8% vs. 35.3%, p = 0.001 *), and the BMI of the POP women was higher than that of the nonPOP women (p = 0.029 *). The mtDNA copy number (p = 0.001 *), collagen III alpha 1 (COL3α1) expression (p = 0.025 *), and MMP2 expression (p = 0.047 *) were significantly higher in the POP group when compared with the nonPOP group. The high BMI women had a higher mtDNA copy number (p = 0.002 *), COL3α1 (p = 0.028 *) gene expressions compared with the standard BMI women. CONCLUSION: In the premenopausal state, higher BMI may be a stronger associate factor than vaginal birth for the development of POP. The higher mtDNA copy number, COL3α1, and MMP2 gene expressions are highly associated with POP in the UL of premenopausal women.
Assuntos
Índice de Massa Corporal , Variações do Número de Cópias de DNA , DNA Mitocondrial/análise , Ligamentos/química , Prolapso de Órgão Pélvico/genética , RNA Mensageiro/análise , Adulto , Estudos de Casos e Controles , Colágeno Tipo III/análise , Colágeno Tipo III/genética , Feminino , Expressão Gênica , Humanos , Metaloproteinase 2 da Matriz/análise , Metaloproteinase 2 da Matriz/genética , Pessoa de Meia-Idade , Prolapso de Órgão Pélvico/metabolismo , Pré-Menopausa , Sacro , ÚteroRESUMO
OBJECTIVE: To ascertain whether low preoperational maximal urethral closure pressure (MUCP) affects the outcomes of single incision sling (SIS) procedures and changes MUCP values postsurgery. MATERIAL AND METHODS: There were 112 (MUCP ≥ 40 cmH2O, n = 88; MUCP < 40 cmH2O, n = 24) consecutive women with urodynamic stress incontinence who had undergone SIS (MiniArc) procedures included in this study. The threshold of 40 cmH2O was used since it has been shown to be a significant risk factor for failed incontinence surgery. Clinical outcomes were assessed by the cough stress test, the 1-hour pad test, the Incontinence Impact Questionnaire-Short Form, the Urogenital Distress Inventory six-item questionnaire, the Sexual Questionnaire-SF, and postoperative changes in the urodynamic parameters. A comparison of the 1-year follow-up data is presented. RESULTS: Three months postsurgery, a significant decrease was observed in the 1-hour pad test, from 20.6 g preoperatively to 0.73 g postoperatively (p < 0.001). The objective cure rate was 82.1% without any significant differences between the two groups (p = 0.202). At 3 months and 1 year after surgery, significantly decreasing Urogenital Distress Inventory six-item questionnaire and Incontinence Impact Questionnaire-Short Form, and increasing Sexual Questionnaire-SF scores were observed in both groups, without any significant differences between the two groups. No statistically significant difference in the subjective cured rate was noted between the two groups at the 3-month and 18.4 month follow-ups. The postoperative MUCP was significantly decreased in the MUCP ≥ 40 group (p < 0.05) while significantly increased in the MUCP < 40 group (p = 0.006). CONCLUSIONS: These results suggest that SIS is a safe and highly effective treatment for urodynamic stress incontinence even in women with low MUCP at a mean follow-up of 18.4 months. Evaluation of the outcomes with more subjects after a longer follow-up period is necessary.
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Slings Suburetrais , Uretra/fisiopatologia , Incontinência Urinária por Estresse/fisiopatologia , Incontinência Urinária por Estresse/cirurgia , Absorventes Higiênicos/estatística & dados numéricos , Adulto , Idoso , Feminino , Seguimentos , Humanos , Pessoa de Meia-Idade , Estudos Retrospectivos , Inquéritos e Questionários , Resultado do Tratamento , UrodinâmicaRESUMO
The newer generation of single-incision slings such as the MiniArc may minimize these risks by avoiding the passage of needles through the obturator foramen and muscles. However, they may still lead to severe vascular injuries. We report a case of a life-threatening obturator hematoma forming after a MiniArc procedure. We determined the exact location using a computed tomographic scan of the pelvis, and it was surgically managed. The patient's symptoms subsided, and her vital signs stabilized after the hematoma was removed using a transvaginal approach. Single-incision slings may be associated with life-threatening vascular complications.
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Hematoma/etiologia , Pelve/diagnóstico por imagem , Implantação de Prótese/efeitos adversos , Incontinência Urinária por Estresse/cirurgia , Adulto , Feminino , Hematoma/diagnóstico por imagem , Hematoma/cirurgia , Humanos , Pelve/cirurgia , Slings Suburetrais , UltrassonografiaRESUMO
INTRODUCTION: In this retrospective study, a comparison is made of the clinical efficacy of two stress urinary incontinence treatment apparatuses, a single-incision sling and a transobturator sling. METHODS: Eighty-five (single-incision n=43, transobturator n=42) consecutive patients were included in this study. Clinical outcomes were assessed by the cough stress test (CST), the pad test, the Impact Questionnaire-Short Form (IIQ-7), the Urogenital Distress Inventory six-item questionnaire (UDI-6), the Sexual Questionnaire-SF (PIS-Q), the pain score, and the postoperative changes in urodynamic parameters. A comparison of the 1-year follow-up data is presented. RESULTS: Three months post-surgery, 81.8% of the single-incision sling group and 74.4% of the transobturator sling group had a negative cough test and a dry pad test. One year after surgery, significantly decreasing UDI-6, IIQ-7, and increasing PIS-Q scores were observed in both groups, while the complication rates remained similar. Postoperatively, the single-incision sling group seems to show a greater improvement in UDI-6 score, require less operation time, and experience less blood loss, less postoperative pain, and a smaller decrease in maximal urethral closure pressure (MUCP). CONCLUSIONS: These results suggest that the single-incision sling and the transobturator sling are equally as effective and safe for the treatment of stress incontinence, as evaluated during the 1-year follow-up. The insertion of a single-incision sling seems to be less painful than that of a conventional sling. One year after surgery, the MUCP and mean flow rate of the transobturator sling group had significantly decreased compared with that of the single-incision sling group.
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Procedimentos Cirúrgicos em Ginecologia/instrumentação , Slings Suburetrais , Incontinência Urinária por Estresse/cirurgia , Adulto , Feminino , Procedimentos Cirúrgicos em Ginecologia/efeitos adversos , Procedimentos Cirúrgicos em Ginecologia/estatística & dados numéricos , Humanos , Pessoa de Meia-Idade , Qualidade de Vida , Estudos Retrospectivos , Resultado do Tratamento , UrodinâmicaRESUMO
OBJECTIVE: To assess retrospectively the efficacy and safety of MONARC (American Medical Systems) transobturator suburethral slings in the treatment of female urodynamic stress incontinence with and without low maximal urethral closure pressure (MUCP). MATERIALS AND METHODS: Seventy-three women with urodynamic stress incontinence, fitted with the transobturator suburethral sling at a medical center in central Taiwan, participated in the study. Objective postoperative evaluations, including a 1-hour pad test, cough stress test, uroflowmetry, and residual urine volume, were conducted 6 months after operation. Subjective outcomes were evaluated by telephone interview. Charts were reviewed for perioperative complications, urinary retention, and requirements for postoperative medication for symptoms of urgency. The mean follow-up was 48 months. RESULTS: Objective cure rate was 80.8% (dry pad test and negative stress test), 82.4% for MUCP less than 30cmH(2)O, and 80.4% for MUCP greater than 30cmH(2)O (p=1.000). Mean pad weight gain changed from 25.8g preoperatively to 1.8g postoperatively (p<0.05). There was no significant change in urinary flow rate or residual volume. Subjectively, 98.6% of subjects experienced complete improvement; only one patient found no improvement. Very few perioperative complications occurred. Immediate postoperative difficulty in voiding occurred in 6.8% of patients. Postoperative de novo urgency was 2.7%. CONCLUSIONS: The MONARC transobturator suburethral sling is a safe and highly effective treatment for stress urinary incontinence even in women with low MUCP at a mean follow-up of 48 months. Evaluation of the outcomes after a longer follow-up period is necessary.
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Slings Suburetrais , Uretra/fisiologia , Uretra/cirurgia , Incontinência Urinária por Estresse/fisiopatologia , Incontinência Urinária por Estresse/cirurgia , Adulto , Feminino , Seguimentos , Humanos , Pessoa de Meia-Idade , Satisfação do Paciente , Complicações Pós-Operatórias , Pressão , Estudos Retrospectivos , Índice de Gravidade de Doença , Resultado do Tratamento , Urodinâmica/fisiologiaRESUMO
INTRODUCTION AND HYPOTHESIS: The optimal duration of urethral catheterization during and after pelvic reconstructive surgery is not established. This study investigated the optimal duration of urinary catheterization in patients undergoing anterior vaginal repair with or without other vaginal surgeries. METHODS: A total of 90 patients were included from April 2007 to March 2008. They were randomly divided into 2, 3, and 4 days urinary catheterization groups based on the color of the questionnaire papers they blindly chose. After catheter removal, the amount of post-void residual urine was used to measure the efficacy of bladder emptying. Differences between groups were determined using Chi-square test, Fisher's exact test, or Kruskal-Wallis test, as appropriate. RESULTS: No significant differences were found in the amount of post-void residual urine between the three catheterization groups. CONCLUSIONS: Our findings suggest that the duration of urethral catheterization after anterior colporrhaphy need not exceed 2 days.
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Cateteres de Demora/efeitos adversos , Complicações Pós-Operatórias/epidemiologia , Cateterismo Urinário/efeitos adversos , Transtornos Urinários/epidemiologia , Distribuição de Qui-Quadrado , Cistocele/epidemiologia , Cistocele/cirurgia , Feminino , Humanos , Pessoa de Meia-Idade , Complicações Pós-Operatórias/etiologia , Fatores de Tempo , Transtornos Urinários/etiologiaAssuntos
Infecções Bacterianas/complicações , Histerectomia , Leiomioma/complicações , Neoplasias Uterinas/complicações , Infecções Bacterianas/diagnóstico por imagem , Infecções Bacterianas/cirurgia , Exsudatos e Transudatos/diagnóstico por imagem , Feminino , Febre/etiologia , Humanos , Leiomioma/diagnóstico por imagem , Leiomioma/cirurgia , Pessoa de Meia-Idade , Necrose , Ultrassonografia , Neoplasias Uterinas/diagnóstico por imagem , Neoplasias Uterinas/cirurgiaRESUMO
INTRODUCTION AND HYPOTHESIS: The pathophysiology of pelvic organ prolapse (POP) is related to aging in the pelvic organ support, and mitochondrial dysfunction is one of the major contributors to aging. Therefore, the objective of this study was to investigate the correlation between alternations of mitochondrial DNA and progression of POP. METHODS: Polymerase chain reaction (PCR) was applied in the present study. Uterosacral ligaments (UL) were obtained from 45 POP patients and 38 myoma patients without POP. Chi-square test, Student's t-test, Mann-Whitney U test, and Spearman correlation analysis were applied in the comparison between POP and non-POP patients. RESULTS: The results revealed that significant depletion of mitochondrial DNA (mtDNA) and an increase in the incidence of 4977 deletion of mtDNA (mtDNA(4977)) in the UL tissue of POP patients. CONCLUSIONS: The alternations of mtDNA may play an important role in the molecular pathogenesis and process of POP formation.
Assuntos
DNA Mitocondrial/genética , DNA Mitocondrial/metabolismo , Deleção de Genes , Dosagem de Genes/genética , Ligamentos/metabolismo , Mitocôndrias/metabolismo , Prolapso Uterino/metabolismo , Adulto , Idoso , Envelhecimento/metabolismo , Biópsia , Estudos de Casos e Controles , Progressão da Doença , Feminino , Humanos , Leiomioma , Ligamentos/patologia , Ligamentos/fisiopatologia , Pessoa de Meia-Idade , Debilidade Muscular/metabolismo , Debilidade Muscular/fisiopatologia , Mioma , Sacro , Neoplasias Uterinas , Prolapso Uterino/etiologia , Prolapso Uterino/fisiopatologia , ÚteroRESUMO
OBJECTIVE: The aim of this study was to retrospectively compare surgical outcomes of the suprapubic arc sling (SPARC) and transobturator suburethral tape (MONARC) for treatment of stress urinary incontinence (SUI) in women. MATERIALS AND METHODS: A total of 74 women treated for SUI using MONARC were compared with 32 treated using SPARC. Postoperative evaluations were conducted at 3-6 months, including 1-hour pad test, cough stress test, uroflowmetry and residual urine volume. Subjective outcomes were evaluated using telephone interviews. Perioperative complications were investigated from chart records. RESULTS: No significant difference was found between the SPARC and MONARC treatment groups in terms of the objective cure rate at 3 months postoperatively (90.6% vs. 80.6%; p = 0.258). However, a significant difference was found between the subjective cure rates of the SPARC and MONARC groups (77.4% vs. 97.3%; p < 0.05). CONCLUSION: Both MONARC and SPARC are safe and effective for surgical treatment of SUI.
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Slings Suburetrais , Incontinência Urinária por Estresse/cirurgia , Adulto , Feminino , Humanos , Satisfação do Paciente , Desenho de Prótese , Estudos Retrospectivos , Resultado do Tratamento , Incontinência Urinária por Estresse/fisiopatologia , UrodinâmicaRESUMO
BACKGROUND: This manuscript compares the efficacy and safety of duloxetine with placebo in Taiwanese women with SUI. METHODS: Taiwanese women with SUI were were randomly assigned to placebo (n = 61) or duloxetine 80 mg/day (n = 60) in this double-blind, 8-week, placebo-controlled study. Outcome variables included: incontinence episode frequency (IEF), Incontinence Quality of Life questionnaire (I-QOL) scores, and Patient Global Impression of Improvement rating (PGI-I). RESULTS: Decrease in IEF was significantly greater in duloxetine-treated than placebo-treated women (69.98% vs 42.56%, P < .001). No treatment differences in I-QOL scores were significant. There were significant differences in PGI-I rating. Treatment-emergent adverse events (TEAEs) were experienced by more duloxetine-treated than placebo-treated women (80.0% vs 44.3%; P < .001). Discontinuations due to adverse events were significantly greater for duloxetine-treated than placebo-treated women (26.7% vs 6.6%; P = .003). CONCLUSION: Data provide evidence for the safety and efficacy of duloxetine for the treatment for Taiwanese women with SUI. TRIAL REGISTRATION: ClinicalTrials.gov Identifier: NCT00475358.
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Inibidores Seletivos de Recaptação de Serotonina/uso terapêutico , Tiofenos/uso terapêutico , Incontinência Urinária por Estresse/tratamento farmacológico , Adulto , Idoso , Método Duplo-Cego , Cloridrato de Duloxetina , Feminino , Humanos , Pessoa de Meia-Idade , TaiwanRESUMO
BACKGROUND: Herein we report a case of obturator hematoma formation which occurred during our 25th case involving the transobturator suburethral tape procedure with the inside-to-out approach. CASE: A case of an obturator hematoma forming after a transobturator suburethral tape procedure is reported. The patient did not become infected and was managed conservatively. The hematoma spontaneously resorbed after 11 weeks and the patient was cured of her incontinence. CONCLUSION: The transobturator approach for suburethral tape placement may be associated with vascular complications.
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Hematoma/etiologia , Pelve/irrigação sanguínea , Complicações Pós-Operatórias/etiologia , Incontinência Urinária por Estresse/cirurgia , Procedimentos Cirúrgicos Urológicos/efeitos adversos , Procedimentos Cirúrgicos Urológicos/métodos , Vasos Sanguíneos/lesões , Feminino , Hematoma/diagnóstico por imagem , Humanos , Pessoa de Meia-Idade , Tomografia Computadorizada por Raios XRESUMO
PURPOSE: We determined overactive bladder symptoms in combination with other lower urinary tract symptoms and illustrated their relationships using a statistical analysis. Furthermore, we also describe the potential contributory factors and adaptation strategies in patients that are associated with overactive bladder subtypes. MATERIALS AND METHODS: A total of 1,930 women with a mean age +/- SD of 46 +/- 15 years (range 15 to 91) with troubling lower urinary tract symptoms were successfully interviewed with a validated questionnaire at the urology and urogynecology clinics at 14 medical centers in Taiwan. The questionnaire was constructed to evaluate 6 lower urinary tract symptoms and 7 adaptation strategies. A log linear statistical model and multiple logistic regression analysis were used to assess the associations among lower urinary tract symptoms and the potential overactive bladder contributory factors, respectively. RESULTS: No single or isolated symptom presented in patients with overactive bladder. Most patients reported a combination with other lower urinary tract symptoms. These female patients can be categorized into 3 groups, including 1 is associated with dry symptoms (urgency, frequency and nocturia), 1 associated with wet symptoms (urgency, urge incontinence and mixed stress incontinence) and a small group that may have overactive bladder symptoms combined with voiding difficulty symptoms. in contrast to patients with dry overactive bladder (urgency associated with frequency and/or nocturia without urge incontinence), after multiple logistic regression analysis patients with wet overactive bladder (urgency with urge incontinence) had a greater average age and higher body mass index, and made more adaptation efforts (p <0.05). CONCLUSIONS: We used statistical analysis to determine and suggest that urgency is the core symptom of female overactive bladder syndrome and there are 3 distinctive overactive bladder subtypes, which differ in their symptom combinations. Different symptom combinations and patient characteristics affect female adaptation to overactive bladder syndrome.
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Incontinência Urinária/diagnóstico , Adolescente , Adulto , Idoso , Idoso de 80 Anos ou mais , Feminino , Humanos , Modelos Lineares , Pessoa de Meia-Idade , Inquéritos e Questionários , Síndrome , Transtornos Urinários/diagnósticoRESUMO
OBJECTIVE: To investigate early postoperative complications of Burch colposuspension and the risk factors that may be associated with failure. METHODS: We retrospectively reviewed the chart records of all patients who underwent Burch colposuspension from October 1997 to September 2002. Indications for colposuspension included urodynamic stress incontinence with bladder neck hypermobility and adequate vaginal capacity. The occurrence of early postoperative complications related to the operation was documented. Subjective failure of the operation was defined as patient dissatisfaction and/or persistent urinary leakage. Chi-square test or Fisher's exact test was used to determine the association among risk factors, early postoperative complications, and the failure rate of Burch colposuspension. RESULTS: A total of 258 patients (92.5%) reported satisfaction with the surgical outcome. The age, parity, menopausal status, use of hormone replacement therapy, previous hysterectomy, and occurrence of early postoperative complications did not significantly influence the failure rate. CONCLUSION: Our results demonstrate that Burch colposuspension is an effective and, according to our patients, highly satisfactory procedure for the treatment of urodynamic stress incontinence.
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Incontinência Urinária por Estresse/cirurgia , Procedimentos Cirúrgicos Urológicos/efeitos adversos , Fatores Etários , Feminino , Terapia de Reposição Hormonal , Humanos , Histerectomia , Prontuários Médicos , Menopausa , Pessoa de Meia-Idade , Paridade , Satisfação do Paciente , Gravidez , Estudos Retrospectivos , Fatores de Risco , Fatores de Tempo , Falha de Tratamento , Resultado do Tratamento , Incontinência Urinária por Estresse/fisiopatologia , UrodinâmicaRESUMO
The purpose of this study was to determine whether the changes of sex hormone-binding globulin (SHBG) affect the pregnancy outcome in women undergoing controlled ovarian hyperstimulation (COH) for assisted reproduction. Forty-five infertile women who were undergoing pituitary desensitization and COH for in vitro fertilization (IVF) with or without intracytoplasmic sperm injection (ICSI) and 19 women with normal menstrual cycles participated in the study. Fasting blood samples of the follicular and luteal phases, including follicular fluid during oocyte retrieval, were obtained for determination of estradiol (E(2)), progesterone (P(4)), testosterone (T), and SHBG concentrations. The SHBG levels increased progressively during the course of COH, but remained constant throughout normal menstrual cycles. A positive correlation existed between E(2) and SHBG levels in both the follicular and luteal phases. The mean plasma SHBG concentration and E(2)/T ratio were significantly higher, while the level of T and the free androgen index were significantly lower, in the luteal phase of women who conceived than in those who did not conceive following COH. The changes of follicular fluid SHBG level and E(2)/T ratio were similar to those in plasma. We concluded, therefore, that increases in SHBG in the follicular and luteal phases may be a reflection of the functional state of ovarian stimulation, and further that such elevations may influence the pregnancy outcome through the modulation of circulating estrogen and androgen balance during down-regulated COH cycles for IVF/ICSI.
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Biomarcadores/sangue , Infertilidade Feminina/sangue , Infertilidade Feminina/terapia , Indução da Ovulação , Resultado da Gravidez , Globulina de Ligação a Hormônio Sexual/metabolismo , Adulto , Estradiol/sangue , Feminino , Fertilização in vitro , Líquido Folicular/metabolismo , Fase Folicular/sangue , Humanos , Fase Luteal/sangue , Valor Preditivo dos Testes , Gravidez , Progesterona/sangue , Injeções de Esperma Intracitoplásmicas , Testosterona/sangueRESUMO
BACKGROUND AND PURPOSE: Women often complain of symptoms related to urination during their pregnancy, but data are limited on the clinical profile and lower urinary tract symptoms (LUTS) of pregnant women in Taiwan. This study assessed the prevalence and predisposing factors of LUTS in Taiwanese women during pregnancy. METHODS: A cross-sectional survey was designed to collect data on the prevalence of LUTS during pregnancy. Women attending the antenatal clinic of a medical center in central Taiwan were recruited and asked to complete a LUTS questionnaire including 12 questions on symptoms related to urination. RESULTS: 799 normal pregnant women were included in this study. The most common LUTS were nocturia (60.2%) and stress urinary incontinence (SUI; 46.1%), followed by urgency (34.1%), frequency (27.8%), incomplete emptying (26.2%), a bearing-down sensation (23.8%), and voiding difficulty (12.6%). The prevalence of nocturia, SUI, urgency, and frequency generally increased as gestational age advanced. There was a significantly higher prevalence of SUI in multiparous women than in nulliparous women; however, the prevalence of urgency, frequency, incomplete emptying, bearing-down sensation, and straining was significantly higher in nulliparous women than in multiparous women. High parity, high body weight before pregnancy and advanced gestational age were the predisposing factors of SUI during pregnancy. Only 6.5% of the pregnant women studied complained that SUI caused a social or hygienic problem based on the International Continence Society (ICS) criteria. CONCLUSIONS: This study provides a profile of LUTS in Taiwanese women during pregnancy. Nocturia was the most common lower urinary tract symptom. Nocturia, SUI, urgency, and frequency increased as gestational age advanced. Parity was a predisposing factor for LUTS during pregnancy, with multiparous women experiencing significantly more SUI while nulliparous women had higher prevalence of other LUTS.
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Complicações na Gravidez/epidemiologia , Transtornos Urinários/epidemiologia , Adulto , Distribuição de Qui-Quadrado , Estudos Transversais , Feminino , Humanos , Gravidez , Prevalência , Inquéritos e Questionários , Taiwan/epidemiologiaRESUMO
Catheterization is considered to be a mandatory procedure for adequate bladder drainage following an anti-incontinence operation until the recovery of normal voiding function occurs. We conducted this prospective study to challenge this practice. A total of 86 patients with genuine stress incontinence who underwent a modified Burch coplosuspension were randomized into two groups based on the day of operation. The study group consisted of 42 patients who had the transurethral Foley catheter removed postoperatively the next morning (Group A). The control group was composed of 43 patients who had the transurethral indwelling catheter left in place until the fifth postoperative day (Group B). The percentages of immediate voiding difficulties in Groups A and B were 7.1% and 0%, respectively ( P>0.05). The postoperative urinary tract infection rates of Groups A and B were 16.6% and 23.3%, respectively ( P>0.05). The success rates of our patients were not compromised after our modified operative procedures (78.6% with dry results and 19.0% with improved symptoms in Group A vs. 74.4% with dry results and 20.9% with improved symptoms in Group B, P >0.05). Our results imply that it is not necessary that an indwelling catheter, for bladder drainage, be left in place until the fifth postoperative day to prevent immediate voiding difficulties.