A new autoimmune disease: atopic dermatitis in children

Atopic dermatitis (AD) is mainly considered an allergy, exacerbated by allergic factors. Is there evidence to suggest the existence of autoimmune components in the pathophysiology of the illness? Studies in the literature that dealt with the occurrence of autoimmunity in children with AD were analyzed. We followed the studies published in PubMed for 10 years, from 2001 to 2021. Clinical signs and symptoms were similar to other autoimmune diseases, having periods of remission and relapses. Other correlations between AD and autoimmune diseases have been described, and patients with AD can also present with a wide range of autoimmune comorbidities. Three major factors contribute to the pathogenesis of AD: damage of the skin barrier, disorders of the immune response, and imbalances of the skin microbiome—all based on genetic changes and influenced by environmental factors. Predominant activation of Th 2 cells, with the increase of Th 1, Th 17, and Th 22 subsets, promotes skin inflammation. All this evidence suggests that AD might be classified as an autoimmune disease, not just as an allergic reaction (AU)

Déclaration de la Sixième Conférence ministérielle sur l’environnement et la santé: Annexe 1. Recueil de mesures possibles pour faire avancer la mise en œuvre de la Déclaration d’Ostrava

Les États membres de la Région européenne de l’OMS se sont engagés à renforcer et à activer les interventions visant à améliorer l’environnement et la santé aux niveaux international, national et sous-national dans le cadre de la Déclaration de la Sixième Conférence ministérielle sur l’environnement et la santé tenue à Ostrava (République tchèque) du 13 au 15 juin 2017. Ce document doit aider les États membres à élaborer des portefeuilles nationaux de mesures. À cet effet, il met en exergue l’importance desthèmes abordés par la déclaration, présente les objectifs à atteindre eu égard à ces priorités et propose des mesures pour y parvenir.

Arterial hypertension - prevalence of risk factors and morbide associations that increase cardiovascular risk.

Hypertension represents a serious problem in Romania, as there are over 3 million hypertensive people in our country. There is a high incidence of deaths caused by hypertension.WE PERFORMED AN ANALYTICAL PROSPECTIVE STUDY THAT AIMS TO DETERMINE: prevalence of arterial hypertension in a population from Cluj county, distribution on age and gender, arterial hypertension severity, association of hypertension with other cardiovascular risk factors. Our study included 2266 patients, age 14 years old up to over 90 years old, both masculine and feminine gender, known with hypertension and new-diagnosed ones. Each subject was submitted to an interview based on a questionnaire. Diagnosis of arterial hypertension was established according to ESH criteria that consider as hypertension: values over 140/90 mmHg. Out of all subjects submitted to the study 647 (29.74%) were diagnosed with arterial hypertension and, from these, 102 (15.13%) were new-diagnosed patients.We found out a predominance of arterial hypertension at the age of 51-60 and over 60, an increased involvement of feminine sex; an association of hypertension with other major cardiovascular risk factors: obesity, diabetes, dislypidemia.Arterial hypertension represents an important health problem in Romania due to an increased prevalence, major impact on morbidity and mortality by cardiovascular and cerebro-vascular disease. These facts accentuate the necessity of an early diagnosis, of making people aware of the severity of the disease and it's impact on their lifestyle.