RESUMO
A new diarylhexane, kneglobularone B (1) and two new diarylpropanols, kneglobularols A - B (2 - 3) along with seven known compounds (4 - 10) were isolated and characterized from the roots of Knema globularia. It is the first time to find arylpropyl quinone (4) and isoflavone (8) in Myristicaceae family. In addition, 5 was found for the first time in Knema genus. Their structures were elucidated by UV, IR, MS, 1 D and 2 D NMR techniques. Compound 4 exhibited strong cytotoxicity against the NCI - H187 and MCF - 7 cell lines with IC50 values of 3.08 and 6.68 µg/mL, respectively.
Assuntos
Myristicaceae , Plantaginaceae , Linhagem Celular Tumoral , Humanos , Células MCF-7 , Estrutura Molecular , Myristicaceae/química , Extratos Vegetais/química , Raízes de Plantas/químicaRESUMO
Two new compounds, dalpulanone (1) and 2-hydroxyisomucronustyrene (2), were isolated from the stems of Dalbergia stipulacea. Fourteen known compounds (3-16) were also isolated. The chemical structures of all isolated compounds were elucidated using spectroscopic methods, including 1D-NMR, 2D-NMR, MS and IR data. Compound 4 displayed the strongest antifungal activity against Pythium insidiosum and had higher activity than the amphotericin-B standard.
Assuntos
Antifúngicos/farmacologia , Dalbergia , Pythium , Antifúngicos/isolamento & purificação , Dalbergia/química , Espectroscopia de Ressonância Magnética , Estrutura Molecular , Compostos Fitoquímicos/isolamento & purificação , Compostos Fitoquímicos/farmacologia , Caules de Planta/química , Pythium/efeitos dos fármacosRESUMO
Four new acylphloroglucinol derivatives 1, 3, 5 and 13 were isolated from the fruits of Horsfieldia irya, and in addition, thirteen known compounds were also discovered. All compounds were evaluated for cytotoxicity against HeLa and HCT116 cell lines, as well as normal cells (Vero cells). Compound 13 showed cytotoxicity against HeLa and HCT116 cell lines with IC50 values of 4.53 ± 0.05 and 4.53 ± 0.16 µg/mL, respectively, and showed less activity against normal cells (IC50 = 13.38 ± 0.75 µg/mL). Compound 13 may be useful for the development of anticancer agents. It was found that decanoyl side chain may be necessary for the cytotoxicity. The chemical structures of all isolated compounds were elucidated using spectroscopic methods including 1 D-NMR, 2 D-NMR, MS and IR data.
Assuntos
Antineoplásicos Fitogênicos , Myristicaceae , Animais , Antineoplásicos Fitogênicos/farmacologia , Chlorocebus aethiops , Frutas , Células HCT116 , Humanos , Estrutura Molecular , Células VeroRESUMO
A new flavonoid, atalantraflavone (1) as well as eight known compounds including atalantoflavone (2), racemoflavone (3), 5,4'-dihydroxy-(3â³,4â³-dihydro-3â³,4â³-dihydroxy)-2â³,2â³-dimethylpyrano-(5â³,6â³:7,8)-flavone (4), lupalbigenin (5), anabellamide (6), citrusinine I (7), p-hydroxybenzaldehyde (8), and frideline (9), were isolated from the leaves of Atalantia monophylla (L.) DC. Focusing on Alzheimer's disease, acetylcholine esterase (AChE) inhibition and antioxidant activity were evaluated using the modified Ellman's method and the ABTS scavenging assay, respectively. It was found that isoflavonoid 5, lupalbigenin, showed 79% inhibition to AChE and was 1.4-fold stronger than the tacrine standard. In addition, acridone 7, citrusinine I, displayed 90.68% antioxidant activity.
Assuntos
Antioxidantes/farmacologia , Inibidores da Colinesterase/farmacologia , Flavonoides/farmacologia , Rutaceae/química , Acridonas/química , Acridonas/farmacologia , Alcaloides/química , Alcaloides/farmacologia , Antioxidantes/química , Inibidores da Colinesterase/química , Avaliação Pré-Clínica de Medicamentos/métodos , Flavonoides/química , Isoflavonas/química , Isoflavonas/farmacologia , Espectroscopia de Ressonância Magnética , Estrutura Molecular , Extratos Vegetais/farmacologia , Folhas de Planta/químicaRESUMO
A new coumarin, scataccanol (1) and 10 known compounds were isolated from the fruits of Scaevola taccada (Gaertn.) Roxb. All compounds were evaluated for antifungal activity against Pythium insidiosum. Compounds 5 and 7 showed strong antifungal activity with minimum inhibitory concentration values of 5 and 10 µg/mL, respectively. Structural determination of all compounds was accomplished by 1D and 2D-NMR, IR and MS.
Assuntos
Antifúngicos/farmacologia , Furocumarinas/isolamento & purificação , Magnoliopsida/química , Pythium/efeitos dos fármacos , Frutas/química , Furocumarinas/química , Furocumarinas/farmacologia , Espectroscopia de Ressonância Magnética , Espectrometria de Massas , Testes de Sensibilidade MicrobianaRESUMO
Five new compounds, including pteroloterins A-C (1, 3, and 4), 1ß-acetoxytaepeenin C (2), and 8aα-hydroxycadinenal (5), and 11 known compounds were isolated from the root bark of Pterolobium macropterum. All compounds were evaluated for cytotoxicity against the cholangiocarcinoma cell lines. Compound 9 showed weak cytotoxicity against the KKU-M139 cell line with an IC50 value of 23.24 ± 0.18 µM and showed no activity against normal cells.
Assuntos
Antineoplásicos Fitogênicos/isolamento & purificação , Fabaceae/química , Terpenos/isolamento & purificação , Antineoplásicos Fitogênicos/química , Antineoplásicos Fitogênicos/farmacologia , Neoplasias dos Ductos Biliares , Ductos Biliares Intra-Hepáticos , Linhagem Celular Tumoral , Colangiocarcinoma , Ensaios de Seleção de Medicamentos Antitumorais , Humanos , Concentração Inibidora 50 , Estrutura Molecular , Osteogênese/efeitos dos fármacos , Casca de Planta/química , Relação Estrutura-Atividade , Terpenos/química , Terpenos/farmacologia , TailândiaRESUMO
Two new compounds, derrivanone (1) and derrischalcone (2), were isolated from the crude hexane extract of the fruits of Derris indica. In addition, 14 known compounds were isolated from the fruits of this plant. Chalcones 2-4 showed strong cytotoxicity against cholangiocarcinoma cell line (M156) and human hepatoma HepG2 cells. In addition, flavanones 15 and 16 exhibited potent and high cytotoxic efficacy.
Assuntos
Antineoplásicos/química , Antineoplásicos/toxicidade , Derris/química , Antineoplásicos/uso terapêutico , Neoplasias dos Ductos Biliares/tratamento farmacológico , Ductos Biliares Intra-Hepáticos , Linhagem Celular Tumoral , Chalconas/química , Colangiocarcinoma/tratamento farmacológico , Flavanonas/química , Flavanonas/toxicidade , Frutas/química , Células Hep G2 , Humanos , Extratos Vegetais/químicaRESUMO
Four new compounds, microminutin B (1), microminutin C (2), micromarinate (3), and secomicromelin (4) as well as 17 known compounds were isolated from the fruits of Micromelum falcatum. All compounds were evaluated for antifungal activity against Pythium insidiosum using disc diffusion assay. P. insidiosum is a fungus-like microorganism for which antifungal agents now available are not effective. The results show that four compounds including secomicromelin (4), 7-methoxy-8-(4'-methyl-3'-furanyl)coumarin (10), micromarin B (17), and isomicromelin (19) could inhibit the mycelia growth of P. insidiosum.
Assuntos
Antifúngicos/química , Cumarínicos/química , Extratos Vegetais/química , Pythium/efeitos dos fármacos , Rutaceae/química , Antifúngicos/isolamento & purificação , Antifúngicos/farmacologia , Cumarínicos/isolamento & purificação , Cumarínicos/farmacologia , Relação Dose-Resposta a Droga , Frutas/química , Espectroscopia de Ressonância Magnética , Testes de Sensibilidade Microbiana , Estrutura Molecular , Extratos Vegetais/isolamento & purificação , Extratos Vegetais/farmacologia , Pythium/crescimento & desenvolvimentoRESUMO
Thirteen compounds were isolated from the stem of Hymenocardia wallichii Tul. A new phenolic compound, wallinol (1), was found in this plant. The other chemical components were squalene (2), stigmasterol (4), homopterocarpin (5), two triterpenes (3 and 13), two benzaldehyde derivatives (6 and 9), three cinnamyl derivatives (7, 11, and 12), a coumarin (8), and a monoglyceride (10). Their structures were elucidated on the basis of spectroscopic methods including IR, HR-ESI-MS, and 1D and 2D NMR data.
