[A Case of Ureteral Sciatic Hernia Improved by Indwelling a Ureteral Stent].

A 75-year-old woman visited our hospital with left lumber pain and fever. Symptoms, and computed tomography imaging revealed left pyelonephritis. Then she was admitted to our hospital for treatment. She improved with tazobactam and piperacillin PIPC infusion immediately and was discharged from the hospital. After that she visited our hospital twice with the same symptoms and was given hospital treatment. A second retrograde pyelography (RP) was performed urgently, and the diagnosis was left ureteral sciatic hernia. Then we placed a left ureteral stent. Three months later, we confirmed that the hydronephrosis was improved and removed the stent. Six months after stent removal, recurrence has not been observed.

[Y-graft replacement with left renal artery reconstruction for acute aortic dissection type B].

A 56-year-old male was admitted to our hospital for acute type B aortic dissection. He received conservative therapy but follow-up computed tomography (CT) revealed a low-enhanced left kidney and severe stenosis of the left common iliac artery due to the expansion of the false lumen. Serum blood urea nitrogen (BUN) and creatinine increased and renovascular hypertension worsened with severe intermittent claudication of the left leg. We performed Y-graft replacement with reconstruction of the left renal artery. Postoperative CT showed a well-enhanced left kidney and no stenosis of the left common iliac artery. Intermittent claudication and renal dysfunction improved and his hypertension became controllable. He was discharged on the 17th postoperative day.

Exercise-induced liver beta2-microglobulin expression is related to lower IgG clearance in the blood.

Voluntary wheel running exercise induced higher antigen-specific IgG in circulating blood is well recognized in mice. This antibody response may be regulated by an exercise-induced mechanism that protects against IgG catabolism. The recent hypothesis that the beta2-microglobulin gene is implicated in IgG protection is investigated further on mice voluntary wheel running. Male C57BL/6N mice were intraperitoneally immunized with 0.375microg/kg (body weight) of tetanus toxoid to induce primary and secondary antibody responses. At the peak concentration of blood tetanus toxoid specific IgG in this experiment, we administered (125)I-labeled mouse IgG. To determine how (125)I-IgG half-life is prolonged in voluntary wheel running exercised mice, we observed the tissue radioactivity (125)I-IgG. Significantly higher blood IgG concentrations were demonstrated in the exercised group compared to non-exercised group (P<.05). The mean value of radioactivity in the liver was higher in the exercised group (P<.05). Furthermore, extracted IgG concentration of exercised mouse liver was higher than that of non-exercised group (P<.05). Immunohistochemical analysis showed dramatically increased tissue IgG in the liver of the exercised group (P<.05). The gene expression of beta2-microglobulin was up-regulated in the exercised mouse liver (P<.05). There is a significant correlation between liver accumulation of (125)I-IgG and (125)I-IgG concentration in the blood (P<.05). In addition, there is a significant correlation between extracted total hepatic IgG and beta2-microglobulin in the liver (P<.05). These findings indicate that voluntary wheel running exercise-induced liver beta2-microglobulin expression is related to lower IgG clearance in the blood.

Voluntary wheel-running exercise enhances antigen-specific antibody-producing splenic B cell response and prolongs IgG half-life in the blood.

Exercise has been recognized to provoke upregulation of antibodies. However, the mechanism has not been explained. We examined the effects of voluntary wheel-running exercise on the number of cells which produce tetanus toxoid (TT)-specific IgG, as well as serum level and clearance of administered 125I-labeled mouse IgG in the blood. Male C57BL/6N mice were randomly divided into a voluntary wheel-running exercise group and a sedentary group. Mice were intraperitoneally immunized with 0.375 microg/kg of TT to induce primary and secondary anti-TT antibody responses. ELISPOT assays that identified TT-specific antibody production were performed on day 0 (Baseline, n = 8) and 22 (EX: n = 8, Non-EX: n = 8) after initial immunization (primary response) and on day 32 (EX: n = 8, Non-EX: n = 7) and 43 (EX: n = 7, Non-EX: n = 7). To explain why serum TT-specific IgG was elevated in the exercise group, we conducted an 125I-labeled mouse IgG clearance test on day 32. ELISPOT counts of secondary responses to TT immunization were significantly higher in the running group than in the sedentary group (P<0.05). The serum anti-TT specific IgG concentration was also significantly higher in the running group (P<0.05) than in the sedentary on day 32. The values of both groups were relatively lower on day 43. The (125)I-labeled mouse IgG was more rapidly cleared in the non-exercised than in the exercised group (P<0.05). These results show that voluntary wheel running upregulates the TT-specific humoral immune response. These reactions may be partly explained by the accelerated induction of TT-specific IgG-producing cells and prolonged serum IgG half-life with voluntary exercise.