[Brain perfusion changes after head trauma assessed by cerebral SPECT with aminophylline test]. / Przeplyw mózgowy i reaktywnosc naczyniowa w odleglym okresie po urazie mózgowym badane przy pomocy tomografii emisyjnej SPECT z testem acetazolamidowym i aminofilinowym.

Tomographic cerebral blood flow SPECT scanning using Tc-99m-HMPAO was performed before and after i.v. administration of aminophylline in 36 patients between 6 months to 11 years after closed head trauma. Asymmetries of brain perfusion were found in 34 patients, normal rCBF distribution in 2 patients. Bi-focused asymmetries on the presumed line: trauma-contra coup were seen in 64% of the patients. In 70.4% of the patients with brain perfusion asymmetries the CT scan was normal. The aminophylline test improved the perfusion in 42% of the patients, indicating preserved perfusion reserve. Persistence of brain perfusion alterations after head trauma exists. Aminophylline test may be useful in the assessment of brain perfusion reserve in post-traumatic focus. Brain perfusion SPECT scans may be useful for medico-legal purposes.

[Tc-99m-MIBI and Tc-99m-HMPAO accumulation in primary and metastatic brain tumors assessed by brain SPECT]. / Akumulacja Tc-99m-MIBI i Tc-99m-HMPAO w pierwotnych i przerzutowych guzach mózgu ocenione tomografia emisyjna SPECT.

Imaging of intracranial lesions is frequently difficult in CT/MRI diagnosis. The introduction of the encephalic tracer MIBI seemed to be a promising alternative. We tried to compare the accumulation of Tc-99m-MIBI and HMPAO CT/MRI interpretationeally difficult intracranial lesions. We did SPECT scanning with single-head and triple-head gammacamera after i.v. administration of Tc-99m-HMPAO/MIBI. We performed HMPAO scanning in 34 patients, MIBI scanning in 41 pts. CT and MRI scanning was performed simultaneously. Histological diagnosis was done intra- and/or postoperatively. Increased accumulation of Tc-99m-MIBI was seen in 7/7 meningiomas (100%), 7/9 gliomas (77%), 10/15 brain metastases (66%), 2/4 unverified. In 5 cases with finally non-neoplastic diagnosis (stroke, a-v malformation) no MIBI accumulation was seen. Increased accumulation of HMPAO was seen in 3/11 gliomas, 2/7 meningiomas, 2/8 metastases and 2/4 unverified. In 4 cases non-neoplastic diagnosis was established. Our results seem to be less promising, than reported so far, particularly for heterogeneous accumulation of MIBI in metastatic tumours. The coupled Tc-99m-MIBI/HMPAO scanning may be useful in primary tumour diagnosis, particularly in meningiomas.