[The effect of calcium antagonists and beta-adrenoblockaders on disordered stomach functions in patients with duodenal peptic ulcer]. / Vliianie antagonistov kal'tsiia i beta-adrenoblokatorov na narushennye funktsii zheludka u bol'nykh iazvennoi bolezn'iu dvenadtsatiperstnoi kishki.

The effect of a single dose of nifedipine or propranolol hydrochloride on gastric acid production and motility has been assessed in 90 duodenal ulcer (DU) patients having the relapse. Intragastric pH-metry showed that the drugs in a dose 20 mg significantly inhibit basal acid production. As indicated by electrogastromyography, nifedipine effect on gastric motility depends on its baseline level. The drug displays a moderate normalizing action (modulating effect) on the dominating frequency, amplitude of motor oscillations and overall capacity of gastric biopotentials. Propranolol hydrochloride noticeably lowered initially high frequency of gastric contractions. Due to nifedipine gastric evacuation inhibits and makes more regular. The authors recommend introduction of nifedipine and propranolol hydrochloride in correction of gastric dysfunction in DU patients.

[Chlorozyl, a new Soviet M-cholinolytic agent, and its effectiveness in duodenal ulcer]. / Khlorozil--novyi otechestvennyi M-kholinolitik i ego éffektivnost' pri iazvennoi bolezni dvenadtsatisperstnoi kishki.

The efficacy of a new peripheral M-cholinolytic, chlorozyl, was studied in two representative groups of duodenal ulcer patients and compared with that of atropine sulfate. The effects of single doses of chlorozyl and atropine on gastric acid production and motor function were under study, as was the effect of a course of treatment lasting 24-26 days on clinical symptoms, impaired gastric functions, healing of the ulcer defect, and remote results (in 1-3 years). The findings evidence that chlorozyl drastically inhibited gastric acid production and normalized motor function after a single administration and a course of treatment (in combination with antacids), rapidly alleviated painful and dyspeptic syndromes and provided ulcer cicatrization in 82 percent of patients, reduced the incidence of recurrences twofold within the first year after a course of treatment. Chlorozyl is much superior to atropine in respect of all the parameters listed; side effects are more rare, this being due to the fact that it poorly penetrates the hematoencephalic barrier and its central effect is weaker.

[Experience with objective evaluation of the action of cimetidine--a blocker of histamine-H2 receptors--in patients with peptic ulcer of the duodenum]. / Opyt ob"ektivnoi otsenki deistviia tsimetidina--blokatora H2-retseptorov gistamina--u bol'nykh iazvennoi bolezn'iu dvenadtsatiperstnoi kishki.

The action of cimetidine, a blocker of H2-histamine receptors, is analysed as compared with the peripheral M-cholinolytics atropine and chlorosyl when administered in single doses and in courses. Study of the drug action on the basic functions of the stomach and on the clinical course of the disease was performed with the aid of the original research methods, mathematic analysis of the pH-grams and electrogastrograms. It was revealed that cimetidine compared very favourably with the peripheral M-cholinolytics as regards the action on acid formation in the stomach, particularly if the drug was applied in single doses, and on the clinical course of the disease, primarily in reference to ulcer cicatrization. However, cimetidine appeared inferior to the cholinolytics in the potency of the inhibitory action on motor function of the stomach both when given in a single dose and in courses.