The effects of short-term group psychodynamic psychotherapy on the personality traits of patients treated in a day ward. / Wplyw krótkoterminowej grupowej psychoterapii psychodynamicznej na cechy osobowosci pacjentów leczonych na oddziale dziennym.

OBJECTIVES: In the literature, there is no research that would indicate how a change in specific personality elements may affect the therapeutic effect of short-term group psychodynamic psychotherapy (STGP). The aim of the study was to evaluate the effect of short-term group psychodynamic psychotherapy on personality traits in apopulation of patients with neurotic and personality disorders in a day ward of neurosis treatment. METHODS: The study involved 139 people with anxiety and personality disorders, including 110 who participated in the control measurements. The dimensions of personality (neuroticism, extraversion, psychoticism, lie) were assessed on the basis of the Eysenck Personality Questionnaire (EPQ) adapted to the Polish conditions. The measurements were made at two time points: (1) before treatment, (2) after 12 weeks of treatment. RESULTS: During therapy the level of neuroticism, extraversion, psychoticism and lie did not change significantly in the group of neurotic patients. In the group of people with personality disorders, the level of neuroticism significantly decreased (p = 0.0008), whereas the level of extraversion increased (p = 0.037). The values for psychoticism and lie did not change significantly in the course of psychotherapy in any group of patients. CONCLUSIONS: The dynamics of changes in neuroticism and extraversion under the influence of short-term group psychodynamic psychotherapy (STGP) in a day ward of neurosis treatment seems to be an important marker for assessing the effectiveness of the treatment in people suffering from personality disorders. There is a need to develop more precise parameters for the assessment of recovery in the group of people with anxiety disorders.

Serotonin-Related Gene Variants in Patients with Irritable Bowel Syndrome and Depressive or Anxiety Disorders.

AIM: To assess the association of six polymorphisms in serotonin-related genes with depressive or anxiety disorders in patients with irritable bowel syndrome (IBS). METHODS: The lifetime prevalence of depressive and anxiety disorders was assessed in 95 IBS patients (85% women) using the Munich version of the Composite International Diagnostic Interview (CIDI). IBS was diagnosed according to the Rome III criteria. SCL6A4 HTTLPR polymorphism (rs4795541) was determined using PCR-based method. Single-nucleotide polymorphisms in HTR1A (rs6295), HTR2A (rs6313 and rs6311), HTR2C (rs6318), and TPH1 (rs1800532) were detected by minisequencing method. RESULTS: IBS patients with depressive disorders were characterized by higher frequency of 5-HTTLPR L allele in comparison to IBS patients with anxiety disorders. The lower frequency of 1438 A allele in HTR2A was found in IBS patients with depressive disorders in comparison to IBS patients without mental disorders. The lower G allele frequency in HTR2C rs6318 polymorphism among IBS patients with anxiety disorders was also observed. CONCLUSIONS: Our results provide further evidence for the involvement of SLC6A4 rs4795541 and HTR2A rs6311 polymorphisms in the pathophysiology of depressive disorders in IBS patients. The new findings indicate that HTR2C rs6318 polymorphism may be associated with the susceptibility to anxiety disorders in IBS patients.

The lifetime prevalence of anxiety disorders among patients with irritable bowel syndrome.

BACKGROUND: The prevalence of irritable bowel syndrome (IBS), the most common functional gastrointestinal disorder, ranges from 10% to 20% in the general population. It is estimated that from 40% to 90% of persons with a diagnosis of IBS suffer from mental disorders, mainly anxiety and depressive disorders. OBJECTIVES: The aim of the study was to assess the lifetime prevalence of anxiety disorders in IBS patients and to compare it with the prevalence of these disorders in a control group of patients with gastroesophageal reflux disease (GERD). MATERIAL AND METHODS: The study included 106 patients with IBS and 53 patients with GERD. IBS was diagnosed according to the Rome II criteria after a basic evaluation to exclude an organic disease. Anxiety disorders were diagnosed using the Composite International Diagnostic Interview (CIDI) in accordance with ICD-10 diagnostic criteria. RESULTS: Anxiety disorders during the patient's lifetime were diagnosed in 50 IBS patients (47%). Specific phobias occurred in 23.5% of them, social phobias in 10.4%, generalized anxiety disorder in 10.4%, panic disorder in 3.8% and agoraphobia in 8.5%. In the control group with GERD, anxiety disorders during the subject's lifetime were diagnosed in 30% of the group. The difference in the prevalence of anxiety disorders between patients with IBS and GERD was statistically significant (p<0.05). CONCLUSIONS: The lifetime prevalence of anxiety disorders in IBS patients was higher than in the control group with GERD (47% vs. 30%). The prevalence rate of anxiety disorders in the control group with GERD was similar to the prevalence rate in the general population.

[Comorbidity of different forms of anxiety disorders and depression]. / Wspólwystepowanie rózonych postaci zaburzen lekowych i depresji.

AIM: Comorbidity of some anxiety disorders and depression were examined in order to compare their statistical closeness. METHOD: Patients treated in an out-patient care center for psychiatric disorders and/or family medicine were recruited. Persons that have anxiety and depressive symptoms as a consequence of somatic illnesses or consequence of other psychiatric disorders were excluded. Disorders were diagnosed a with diagnostic questionnaire based on Schedule for Assessment in Neuropsychiatry (SCAN), version 2.0, according to ICD-10 criteria. Analyses include selected disorders: generalized anxiety disorder, panic disorder, agoraphobia, specific phobias, social phobia and depression. RESULTS: 104 patients were included. 35 of them (33.7%) had anxiety disorders, 13 persons (12.5%) have depression. Analyses show that in patients with generalized anxiety disorder, depression occurred at least twice as often as in the remaining patients (odds ratio = 7.1), while in patients with agoraphobia the occurrence of panic disorder increased at least by 2.88 times (odds ratio = 11.9). In other disorders the odds ratios was greater than 1, but the differences were not statistically significant. CONCLUSION: Depression/generalized anxiety disorder and agoraphobia/panic disorder were shown to be statistically closer than other disorders.