[Intracerebral connections after administration of kainate into the caudal part of ventral sections of the medulla oblongata]. / Vnutrimozgovye sviazi posle vvedeniia kainata v kaudal'nuiu chast' ventral'nykh otdelov prodolgovatogo mozga.

It was found that 1 day after unilateral destruction with kainate of neurons in the caudal ventral medulla unanesthetized animals showed disorders of arterial pressure control with a prevalence of hypertensive response. In 7 days after operation there was a decrease in the rate of neuronal uptake of serotonin and an increase in choline-, dopamine-, noradrenaline-, and glycinergic mediation in the basal hypothalamus and rostral ventral medulla, which characterize the functional state of synaptic formations in the brain stem structures connected to neurons in the caudal ventral medulla and involved in cardiovascular regulation.

[Glucocorticoid control of the mediator process in the brain structures during immediate adaptation]. / Gliukokortikoidnyi kontrol' mediatornykh protsessov v strukturakh golovnogo mozga pri srochnoi adaptatsii.

In male rats with a high and low blood levels of corticosterone, the activity of serotonin-, dopamine-, noradrenaline-, glycine, GABA-, and cholinergic processes was shown to depend on the glycocorticoid content in the organism and receptor binding of 3H-corticosterone in different brain structures. The formation of adequate processes of neurotransmitter adaptation to a short-term vibration is only possible at a fairly high level of glycocorticoids in the organism.

[Modifying effects of neurotropin on post-radiation disorders of neuromediator processes in the autonomic function regulation centers]. / Modifitsiruiuschchie éffekty neirotropina na postluchevye narusheniianeiromediatornykh protsessov v tsentrakh reguliatsii vegetativnykh funktsii.

In experiments on Wistar rats, it was shown that 6 months after exposure to ionizing radiation (X-radiation 0.5 Gy and intraperitoneal 131I 6.5 mCu/kg) the hypothyroid state was accompanied by changes in inhibitory and excitatory mediation that are characteristic of chronic radiation stress in cerebral structures responsible for regulation of autonomic and animal functions and a relative deficiency of the hypothalamopituitary-adrenocortical axis. Application of therapeutic doses of neurotropin 3 months after radiation levelled the pattern of chronic radiation stress and diencephalic disorders that underlie disturbances of some systemic functions of the organism.

[The role of glucocorticoids in the post-vibration changes in inhibition mediation in the brain structures]. / Rol' gliukokortikoidov v postvibratsionnykh sdvigakh tormoznoi mediatsii v strukturakh golovnogo mozga.

Low-frequency vertical vibration for 2 hours together with three-fold increase of glucocorticoids is accompanied by the disruption of typical relationships of neuromediator processes (norepinephrine- and serotoninergic mediation) as well as the reduction of the intensity of choline trapping with glucocorticoid perception. Glucocorticoid-related conformation changes in plasma membranes and a drastic increase of the cAMP level provide plasticity of both nonspecific (hypothalamus, raphe bluish sites and nuclei) and specific (Deiters' nuclei) structures. The relationships of neuromediator processes in different CNS structures depend on the content of glucocorticoids. This should be taken into consideration when developing pathogenetically adequate methods for restoring the vestibular component of the motion sickness syndrome.

[Mediator processes in the brain structures in the late periods after external and combined exposure to ionizing radiation]. / Mediatornye protsessy v strukturakh golovnogo mozga v otdalennye sroki posle vneshnego i sochetannogo vozdeistviia ioniziruiushchei radiatsii.

In experiments with mature Wistar male rats it was shown that X-radiation of 12.9 mCi/kg and the combined effect of X-rays and 131I of 6.5 mCi/kg changed the rate of mediator processes in the structures responsible for the hypothalamic function regulation. At remote times (6 months) following irradiation differences were observed in the discoordination of mediator interrelations associated with the peculiarities of the indirect effect of external and combined irradiation implemented via endocrine mechanism system.

[Early effects of the influence of ionizing radiation in relatively small doses on the neuromediator systems responding to the central regulation of the hypothalamo-pituitary-adrenal cortex system]. / Rannye éffekty vliianiia ioniziruiushchei radiatsii v otnositel'no nebol'shikh dozakh na neiromediatornye sistemy, otvetstvennye za tsentral'nuiu reguliatsiiu gipotalamo-gipofiz-adrenokortikal'noi sistemy.

In experiments with mature Wistar male rats changes of mediator interrelations in different brain parts, responsible for the central regulation of the hypothalamo-pituitary-adrenocortical system, were detected at early times after whole-body X-irradiation with a dose of 12.9 mC/kg. These changes represent one of the major mechanisms leading, at later times after irradiation, to the development of syndromes related to diencephalic disturbances.

[Significance of adrenal hormones in brain energy metabolism]. / Nekotorye svedeniia o znachenii formonov nadpochechnikov v energeticheskom obmene mozga.

Intensity of glycolysis was studied under conditions of immobilization stress and adrenalectomy as well as with administration of adrenaline and hydrocortisone. The processes of aerobic glycolysis, activity of enzymes of the tricarboxylic acid cycle and mitochondria respiratory chain, content of total, free and protein-bound glycogen, glucose-I-phosphate, glucose-6-phosphate, pyruvate, alpha-ketoglutarate, cytrate and macroergs in the brain are shown to depend on the level of adrenal hormones producing a multilateral effect on a series of energy metabolism links.