RESUMO
The present study evaluates the effects of agmatine on histopathological damage following traumatic injury using a clinically relevant model of diffuse brain injury. A total of 27 male Sprague-Dawley rats weighing 200-225 g were anaesthetised and subjected to head trauma using Marmarou's impact-acceleration model. The rats were then separated into two main groups: one was treated with agmatine and the other with saline for up to 4 days immediately after head trauma. Rats from both groups were killed 1, 3 or 8 days post-injury. The brains were examined histopathologically and scored according to the axonal, neuronal and vascular changes associated with diffuse brain injury. There were no significant differences between the groups at 1 day or 3 days after trauma, but evaluation after 8 days revealed a significant improvement in the group treated with agmatine. Our data indicate that agmatine has a beneficial effect in diffuse brain injury and should be trialled for therapeutic use in the management of this condition.
Assuntos
Agmatina/farmacologia , Lesões Encefálicas/tratamento farmacológico , Encéfalo/patologia , Neurônios/efeitos dos fármacos , Neurotransmissores/farmacologia , Animais , Axônios/efeitos dos fármacos , Axônios/patologia , Encéfalo/irrigação sanguínea , Encéfalo/efeitos dos fármacos , Lesões Encefálicas/patologia , Circulação Cerebrovascular/efeitos dos fármacos , Modelos Animais de Doenças , Traumatismos Cranianos Fechados/complicações , Masculino , Neurônios/patologia , Fármacos Neuroprotetores/farmacologia , Distribuição Aleatória , Ratos , Ratos Sprague-Dawley , Estatísticas não Paramétricas , Fatores de Tempo , Resultado do TratamentoRESUMO
Cerebral alveolar echinococcis is a biologically aggressive infestation that mimics a malignant neoplasm radiologically and macroscopically. This paper describes the clinical and radiological aspects of the disease, with new diagnostic studies, and discusses the surgical treatment of this infestation. The records of five patients with cerebral alveolar echinococcis treated at our center between 2000 and 2004 were reviewed. Three patients underwent radical surgical treatment and received antihelminthic therapy post-operatively, two of whom experienced asymptomatic recurrence. Two patients with multiple lesions were treated with antihelminthic therapy alone. The prognosis was poor for these patients. Radical surgery combined with antihelminthic therapy of sufficient duration are mandatory to prevent the progression of symptoms but the disease continues to be difficult to cure.
Assuntos
Encefalopatias/parasitologia , Equinococose/diagnóstico , Adulto , Anti-Helmínticos/uso terapêutico , Encefalopatias/diagnóstico , Encefalopatias/terapia , Neoplasias Encefálicas/diagnóstico , Diagnóstico Diferencial , Equinococose/terapia , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Estudos Retrospectivos , Resultado do TratamentoRESUMO
Spinal intramedullary ependymal cysts are extremely rare. Fourteen cases have been reported in the literature, and only one was associated with another congenital lesion. The authors describe the case of a 33-year-old man in whom an intramedullary ependymal cyst and filar lipoma were present. These lesions were diagnosed using magnetic resonance imaging and were treated surgically. Pathological examination confirmed the diagnosis. At 6 months postsurgery, there was no evidence of recurrence.
