RESUMO
The number of CD3(+)CD56-HLA-G(+) cells in the peripheral blood of breast cancer patients was shown to increase by 2 times. Our results and published data suggest that the increase in the relative content of CD3(+)CD56-HLA-G(+) cells in the circulating blood in breast cancer contributes to tumor development due to suppression of antitumor immunity.
Assuntos
Neoplasias da Mama/imunologia , Antígenos HLA-G/imunologia , Imunidade Inata , Subpopulações de Linfócitos T/imunologia , Adulto , Neoplasias da Mama/genética , Neoplasias da Mama/patologia , Complexo CD3/genética , Complexo CD3/imunologia , Antígeno CD56/genética , Antígeno CD56/imunologia , Estudos de Casos e Controles , Feminino , Citometria de Fluxo , Expressão Gênica , Antígenos HLA-G/genética , Humanos , Imunofenotipagem , Interferon gama/genética , Interferon gama/imunologia , Interleucina-10/genética , Interleucina-10/imunologia , Contagem de Linfócitos , Pessoa de Meia-Idade , Estadiamento de Neoplasias , Subpopulações de Linfócitos T/patologia , Fator de Crescimento Transformador beta/genética , Fator de Crescimento Transformador beta/imunologiaRESUMO
Data are described on a retrospective immunohistochemical study of the Ki-67, PCNA, Bcl-2, BAX, BclX and VEGF expression in tumors of two groups of patients with breast cancer (BC) and with the favorable and unfavorable clinical courses. A reliably high level of VEGF expression was detected in tumors of patients with an early BC relapse. Apart from VEGF, higher levels of the Ki-67 and PCNA expression were registered in tumors of the discussed patient's category. It can be suggested that the expression parameters of VEGF, Ki-67 and PCNA in the primary tumor can be made use of in evaluating the BD prognostications or describing the features of high-risk groups with a high probability of early disease relapses.
Assuntos
Biomarcadores Tumorais/biossíntese , Neoplasias da Mama/metabolismo , Adulto , Idoso , Neoplasias da Mama/diagnóstico , Análise Discriminante , Feminino , Humanos , Antígeno Ki-67/biossíntese , Pessoa de Meia-Idade , Prognóstico , Antígeno Nuclear de Célula em Proliferação/biossíntese , Proteínas Proto-Oncogênicas c-bcl-2/biossíntese , Estudos Retrospectivos , Sensibilidade e Especificidade , Fatores de Crescimento do Endotélio Vascular/biossíntese , Proteína X Associada a bcl-2 , Proteína bcl-XRESUMO
We carried out a retrospective immunohistochemical study of Ki-67, PCNA, Bcl-2, BAX, BclX, and VEGF expression in tumors of two groups of breast cancer patients with favorable and unfavorable course of the disease. Considerably enhanced VEGF expression was detected in tumors of patients with early relapses of breast cancer. High VEGF expression was paralleled by high level of Ki-67 and PCNA expression in tumors. It can be hypothesized that expression of VEGF, Ki-67, and PCNA in primary tumor can be used for predicting the course of breast cancer or detecting the patients at a high risk of early relapses.