Divergent Mortality Patterns Associated With Dementia in the United States: 1999-2020.

Objective: To analyze contemporary trends of dementia and dementia-related mortality in the United States between 1999 and 2020 categorized by demographic and regional attributes.Methods: A retrospective cohort analysis was conducted using mortality data from individuals aged 35 years to ≥85 years, where dementia/Alzheimer disease was recorded as a contributing or underlying cause of death. Data were extracted from the US Centers for Disease Control and Prevention's Wide-Ranging Online Data for Epidemiologic Research database for the years 1999-2020. Mortality rates adjusted for age due to dementia (annual age-adjusted mortality rate [AAMR]) per 10,000 individuals in the United States were categorized by gender, racial and ethnic groups, and geographic regions.Results: Results revealed 6,601,680 deaths related to dementia between 1999 and 2020. Among these, 85.5% were non-Hispanic (NH) white, 8% NH black, 4.34% Hispanic or Latino, 1.6% NH Asian or Pacific Islander, and 0.3% NH American Indian or Alaska Native adults. The overall AAMR was 17.49, with women experiencing a higher AAMR of 18.19 compared to men (16.05). Ethnic disparities were evident, with NH black adults having the highest AAMR (18.23), followed by NH white (18.09) and Hispanic adults (12.7). Over the study period, the overall AAMR increased from 10.86 in 1999 to 21.42 in 2020, with a notable 18.4% rise in the AAMR from 1999 to 2001. From 2001 to 2020, the average percent change of the AAMR was 1.0%. This upward trend in mortality was observed for both men and women and across all ethnicities.Conclusions: The study spanning 1999-2020 revealed concerning trends in dementia-related mortality in the United States. There is a critical need for targeted health care policy initiatives aimed at mitigating the increasing dementia burden.Prim Care Companion CNS Disord 2024;26(4):24m03724. Author affiliations are listed at the end of this article.

Bibliometric analysis of publication trends on ocular hygiene and infections in the past two decades.

Background: Ocular hygiene encompasses a spectrum of measures to initiate and maintain adequate ocular cleanliness to prevent eye infections and their further transmission. These infections affect all age groups and can lead to severe complications such as blindness. Nearly 1 billion cases could have been prevented out of over 2.2 billion people that are visually impaired worldwide. This bibliometric analysis focuses on the papers published on ocular hygiene and infections. Methods: We searched in the Scopus database from 2004 to 2024. After manual screening, a list of the 100 most-cited original articles was obtained, which was analysed for various factors, including temporal trends, subject areas, authorship patterns, country of origin, funding bodies, etc. Results: There has been a gradual decline over the past two decades in the number of publications. The United States was affiliated with the highest number of publications (n=61), followed by The United Kingdom (n=12) and Gambia (n=8). Several authors had 4 or more publications, with the highest number of publications by Rouse, B. T. (n=14). The American Journal of Ophthalmology takes the lead with 15 publications, while the National Eye Institute (n=23) was the leading funding body. Examination of institutional contributions shows that The University of Tennessee, Knoxville and UT College of Veterinary Medicine stand out with twelve publications each. Nearly half the publications belong to the field of medicine. However, significant publications also come from the fields Neuroscience, Microbiology and Immunology, Biochemistry, Genetics and Molecular Biology, etc. These findings highlight that there is great potential to conduct research to propagate ocular hygiene to prevent adverse effects of infections.

Does institutional quality complement the relationship between ownership structure and corporate social responsibility?

The key purpose of the Study is to examine if institutional quality complements the relationship between Ownership Structure and Corporate Social Responsibility disclosure and performance in the light of legitimacy and agency theory. To the best of my knowledge, it is the first study in literature of finance. The sample comprises of 112 top-performing listed firms (based on market capitalization) at Pakistan Stock Exchange from 2010 to 2019. Institutional quality comprised of world governance indicators which is developed via principal component analysis, an instrumental variable approach and content analysis are used for CSR Disclosure Index to demonstrate the relationship between ownership structure and CSR. The resources complementary phenomenon is adopted to examine the institutional quality's role. Our results show significantly positive impact of Institutional and Foreign Ownerships on CSR while negative significant influence of CEO Duality and Family Ownership on CSR, suggesting that well governed firms will be more socially responsible. In addition, the findings suggest the institutional quality's positive moderating role on the relationship between ownership structure and CSR, signifying the institutional quality's complementary role for the weak corporate environment in Pakistan. Our findings are robust to a series of tests by using Generalized Method of Moment (GMM).

Post-operative infections after cardiothoracic surgery and vascular procedures: a bibliometric and visual analysis of the 100 most-cited articles in the past 2 decades.

Aim: To recognize and analyze the 100 most-cited articles on post-operative infections following cardiothoracic surgery and vascular procedures in the past 20 years. Methods: Articles published on post-operative infections following cardiothoracic surgery and vascular procedures from inception 1986 till 2020 were reviewed and selected by two authors, based on their number of citations using the Scopus database. Their characteristics were recorded, i.e., title, authors, publication date, total no. of citations, citations per year (CPY), country of research, institutional affiliation, journal, research subject, and article type. Results: The top 100 most influential articles were published between 1968 and 2017, with the peak in 2002. The mean number of total citations was 236.79 (range: 108-1,157). Areas with a medical focus were predominant in the studied research articles on the researched topic. The top-most journals in which these articles were published include Annals of Thoracic Surgery (14), followed by Circulation (8), and the New England Journal of Medicine (8). The number of publications affiliated with an institution were highest in the United States, with the Cleveland Clinic Foundation (6) having the most. Conclusion: These findings highlight that there is a great potential to conduct research and publish the prevalence, causes, risk factors, pathogenesis and molecular biology of post-cardiac and -vascular surgery infections to prevent their adverse effects. The results can be taken into consideration for policy making to improve post-cardiac-surgery outcomes.

Rotavirus trends and distribution of genotypes before and during COVID-19 pandemic era: Bangladesh, 2017-2021.

Rotavirus gastroenteritis is accountable for an estimated 128 500 deaths among children younger than 5 years worldwide, and the majority occur in low-income countries. Although the clinical trials of rotavirus vaccines in Bangladesh revealed a significant reduction of severe rotavirus disease by around 50%, the vaccines are not yet included in the routine immunization program. The present study was designed to provide data on rotavirus diarrhea with clinical profiles and genotypes before (2017-2019) and during the COVID-19 pandemic period (2020-2021). Fecal samples were collected from 2% of the diarrheal patients at icddr,b Dhaka hospital of all ages between January 2017 and December 2021 and were tested for VP6 rotavirus antigen using ELISA. The clinical manifestations such as fever, duration of diarrhea and hospitalization, number of stools, and dehydration and so on were collected from the surveillance database (n = 3127). Of the positive samples, 10% were randomly selected for genotyping using Sanger sequencing method. A total of 12 705 fecal samples were screened for rotavirus A antigen by enzyme immunoassay. Overall, 3369 (27%) were rotavirus antigen-positive, of whom children <2 years had the highest prevalence (88.6%). The risk of rotavirus A infection was 4.2 times higher in winter than in summer. Overall, G3P[8] was the most prominent genotype (45.3%), followed by G1P[8] (32.1%), G9P[8] (6.8%), and G2P[4] (6.1%). The other unusual combinations, such as G1P[4], G1P[6], G2P[6], G3P[4], G3P[6], and G9P[6], were also present. Genetic analysis on Bangladeshi strains revealed that the selection pressure (dN/dS) was estimated as <1. The number of hospital visits showed a 37% drop during the COVID-19 pandemic relative to the years before the pandemic. Conversely, there was a notable increase in the rate of rotavirus positivity during the pandemic (34%, p < 0.00) compared to the period before COVID-19 (23%). Among the various clinical symptoms, only the occurrence of watery stool significantly increased during the pandemic. The G2P[4] strain showed a sudden rise (19%) in 2020, which then declined in 2021. In the same year, G1P[8] was more prevalent than G3P[8] (40% vs. 38%, respectively). The remaining genotypes were negligible and did not exhibit much fluctuation. This study reveals that the rotavirus burden remained high during the COVID-19 prepandemic and pandemic in Bangladesh. Considering the lack of antigenic variations between the circulating and vaccine-targeted strains, integrating the vaccine into the national immunization program could reduce the prevalence of the disease, the number of hospitalizations, and the severity of cases.

Unveiling the gender gap in research: a bibliometric analysis of the 100 most-cited articles on food-borne pathogen outbreaks from 1990 to 2020.

Introduction: Despite a recent increase in the representation of female authors in scientific literature, a significant gap persists concerning the inclusion of women in research. This necessitates the analysis of published literature from a gender perspective. This study aimed to provide gender distribution in authorship in the 100 most-cited articles on food-borne pathogen outbreaks from 1990 to 2020. Methods: Bibliometric analysis was conducted using the Scopus database. Two reviewers were selected to search the database. We included the 100 most-cited articles on foodborne outbreak investigations. The analysis was conducted using Statistical Package for Social Sciences (SPSS) version 26 and Microsoft Excel version 2016. The citation data, including total citations, citations per year, and representation of women as first and senior authors, was analyzed in terms of frequencies, mean, median, and interquartile range. The correlation between journal impact factor and the representation of women in high-impact factor journals was determined. A p-value of <0.05 was considered significant. Results: Most of the top-cited articles were published between 2001 and 2010 (n=47). The top 3 most-cited articles were from the USA. Of the total 100 articles, women were the first and last authors in 46% and 28% of the articles, respectively, reflecting a significant gender gap. However, the proportion of females as principal investigators gradually increased from 25% (n=10/30) to 52% (n=24/47) during the period 2001-2010 and to 92% (n=12/13) during 2011-2020. The USA had the highest number of included articles (n=48), and women were principal authors in 56% (n=27) of them. The lowest representation of women was observed in Austria, Denmark, Japan, Netherlands, New Zealand, Nigeria, Portugal, and the United Kingdom. Conclusion: Women are under-represented in published literature on food-borne pathogen outbreaks. Although the representation of women as principal authors has recently increased, disparities still exist at the senior-author level, calling for women's advancement in academic science.

Intraoperative Neurophysiological Monitoring in Corrective Surgery of Scoliosis - Experience at a Tertiary Care Hospital.

OBJECTIVE: To evaluate the role of intraoperative neurophysiological monitoring (IONM) in reducing the postoperative neurologic deficit following corrective surgery of scoliosis. STUDY DESIGN: Observational Study. Place and Duration of the Study: Spine Surgery Department, Combined Military Hospital, Rawalpindi, from December 2022 to May 2023. METHODOLOGY: The study included 170 cases of scoliosis operated under multimodal IONM. Decreased amplitude of ≥50% in SSEP or 70-80% in MEPs were considered warning signs. Cases were divided into two groups: Group 1 (signal drop) and Group 2 (no signal drop). Group 1 was subdivided into Group 1a (true positive), Group 1b (false positive) and Group 1c (intermediate positive). Group 2 was subdivided into Group 2a (true negative) and Group 2b (false negative). RESULTS: Evoked potential changes were observed in 27 (15.9%) cases. This includes transient drop of signals in 16 (9.4%) and sustained drop of signals in 11 (6.5%) cases. Among sustained signal drop, 9 (5.29%) cases had exhibited postoperative neurological deficit whereas 2 (1.17%) cases did not show postoperative neurological deficit (false positive). Multimodal IONM in the current study shows sensitivity of 100%, specificity of 98.6%, positive predictive value of 92.6%, and negative predictive value of 100%. CONCLUSION: Multimodal IONM reduces the incidence of postoperative neurological deficit in corrective surgery of scoliosis by effectively detecting neurologic injury during surgery. Monitoring events alert surgical team to exercise immediate corrective measures which likely results in recovery of lost signals and predict the favorable outcome. KEY WORDS: Intraoperative monitoring, Motor evoked potentials, Neurological deficit, Scoliosis, Somatosensory evoked potentials.

Efficacy and Safety of Lotilaner Ophthalmic Solution (0.25%) for the Treatment of Demodex Blepharitis: A GRADE Assessed Systematic Review and Meta-Analysis of Observational & Experimental Studies.

PURPOSE: Several treatments have been in use for Demodex blepharitis, before the discovery of lotilaner, like tea tree oil and antibiotics; however, they either have irritable effects or systemic adverse effects, respectively. Lotilaner, a novel ectoparasiticide, has been proposed as a treatment for patients grappling with Demodex blepharitis. This review aims to assess the safety and efficacy of lotilaner in the treatment of Demodex blepharitis. DESIGN: Systematic review and meta-analysis. METHODS: An extensive search was conducted on PubMed, Cochrane Library, Scopus, and Google Scholar to find relevant literature till July 31, 2023 following the PRISMA guidelines. A total of 143 articles were retrieved by database searching, out of which 6 studies met the inclusion criteria and were included in the review. Four randomized controlled trials were included in the meta-analysis of mite eradication incidence. The review is registered with PROSPERO: CRD42023459997. RESULTS: Lotilaner is effective in eradicating Demodex mites in individuals suffering from Demodex blepharitis according to RR for the intervention versus the control group of 3.55 (95% confidence interval [CI]: 2.87-4.40, P < .00001, I2 = 0%). The meta-analysis of clinically meaningful collarette score revealed the summary RR for the intervention versus the control group was 3.15 (95% CI: 2.56-3.89, P < 0.00001, I2 = 27%). In conclusion, the results of the included studies were comparable and consistent. CONCLUSIONS: Our results indicated that lotilaner is an effective, well-tolerated, and promising drug in treating patients with Demodex blepharitis. Lotilaner administration and cost-effectiveness should now be contemplated for the study population as these constituents have a vital impact on its treatment success.

Adiponectin blood levels and autism spectrum disorders: a systematic review.

OBJECTIVE: To review the relationship between adiponectin levels and autism spectrum disorders (ASDs) in children. BACKGROUND: ASDs are associated with pervasive social interaction and communication abnormalities. Researchers have studied various pathophysiological mechanisms underlying ASDs to identify predictors for an early diagnosis to optimize treatment outcomes. Immune dysfunction, perhaps mediated by a decrease in anti-inflammatory adipokine, adiponectin, along with changes in other adipokines, may play a central role in increasing the risk for ASDs. However, other factors, such as low maternal vitamin D levels, atherosclerosis, diabetes, obesity, cardio-metabolic diseases, preterm delivery, and oxytocin gene polymorphism may also contribute to increased risk for ASDs. METHODS: Searches on the database; PubMed, Google Scholar, and Cochrane using keywords; adiponectin, adipokines, ASD, autism, autistic disorder, included English-language studies published till September 2022. Data were extracted on mean differences between adiponectin levels in children with and without ASDs. RESULTS: The search yielded six studies providing data on adiponectin levels in young patients with ASDs. As can be seen from Table 1, four of the six studies were positive for an inverse correlation between ASD and adiponectin levels. In addition, two of the four positive and one negative studies found low adiponectin levels associated with and the severity of autistic symptoms. However, results from one reviewed study were insignificant. CONCLUSION: Most studies reviewed yielded lower adiponectin levels in children with ASDs as well as the severity of autistic symptoms.

Unveiling the Latest Advancements in Vanadium Carbide MXene based Supercapacitors and their Future Trends.

Vanadium-carbide-based MXenes have bewitched the scientific community due to their distinctive characteristics, which make them potential candidates for several technological applications, such as supercapacitors (SCs), batteries, gas separation, biological sensors, and desalination. This article provides an overview of recent developments in the synthesis and applications of vanadium-carbide MXene in SCs. Vanadium carbide is one of the most difficult MXenes to synthesize, and various synthesis techniques, including electrochemical exfoliation and chemical etching, have been utilized to fabricate this material. Additionally, the review article also emphasizes the potential use of vanadium carbide MXene as SCs. Finally, the paper concludes with the challenges faced in the synthesis process and the prospects of vanadium carbide MXene-based material fabrication. Overall, this review article provides in-depth and detailed information on recent research on vanadium carbide MXene and its possible uses.

Digital Coaching and Mental Skills Development in Sports: Harnessing the Power of Information Technology / Entrenamiento digital y desarrollo de habilidades mentales en el deporte: aprovechar el poder de la tecnología de la información

The essential purpose of this research study is to determine the digital coaching and mental skills development in sports. This research study also describes the harnessing power of information technology between them. This research depends upon primary research data analysis for measuring the research develop different research questions related to the variables. Digital coaching and mental skills development are independent variables; the sport and information technology are dependent variables. To determine the research study used, SPSS software results determine descriptive statistics, one-way ANOVA test analysis, the regression analysis, and control chart related to dependent and independent variables. The overall result found that digital coaching shows a positive also significant link in sport harnessing of information technology. Mental skills development also shows a direct link in sports related to information technology.(AU)

Research on the use of 3D modeling and motion capture technologies for making sports training easier / Investigación sobre el uso de tecnologías de modelado 3D y captura de movimiento para facilitar el entrenamiento deportivo

The essential purpose of this research study is to measure the study on the use of 3D modeling and motion capture technologies for making sports training easier. This research study was conducted in china for determines whether the research study used specific MCQs-based questions related to the research topic included and its variables. 3D modeling is an independent variable, and motion capture technologies are the independent variable for determining the sport training effects and how it’s easier. This research study depends upon it became. To determine the research study used analytical software of smart PLS and generated specific results, including the smart PLS Algorithm model, segmentation analysis, indicator correlation, and significant analysis. This research study describes the econometric model between dependent and independent variables. A comprehensive research study found that there is a positive effect of 3d modeling and motion capture technologies on sports training. This quality feedback is very good for encouraging the players to play good sports. In the sports field, one major problem regarding the result and timing of various sports has been solved using electronic technology timers. These electronic timers automatically calculate the timing of an athlete during a sport, and the data then provides help in predicting the winner of any sport.(AU)

Information technology and its’ modernization, the Internet, and sport psychology / Las tecnologías de la información y su modernización, Internet y la psicología del deporte

This research aims to describe information technology and its' modernization, the Internet, and sports psychology. A research study based on primary data collected used open-ended and closed-ended questions related to the variable and defined Internet modernization and sports psychology. This research study determines by smart PLS software. It generates a different result, including indicator correlations, discriminant validity, model fitness analysis, composite reliability, and an intelligent PLS Algorithm model related to the variables. Information technology is the leading independent variable. The Internet and sports psychology are both dependent variables. The result found that information technology presents significant and positive relation to the modernization of the Internet. Information technology also shows the direct impact and significance of sport psychology It plays a vital role in the modernization internet also sports psychology performance.(AU)

Research methods and information technology applications in movement science and sport psychology / Métodos de investigación y aplicaciones de la tecnología de la información en la ciencia del movimiento y la psicología del deporte

The primary purpose of this research study is to describe the methods and information technology applications in movement science and sports psychology. This research study depends upon theoretical form, and secondary data in this research paper describe the application of information technology in sport psychology and movement of sciences. For data determination, used EVIEWS software and some general tests included descriptive statistics, correlation coefficient, unit root test analysis, an examination of equality, and histogram & state related to the variables. The research study also defined the application of each variable. The overall result found positive methods and information technology applications in movement science and sports psychology.(AU)

The impact of human-computer interaction on innovations and sports psychology

This study's major objective is to examine the impact of human-computer interaction on innovation and sports psychology. This research study utilized questions linked to independent and dependent variables based on primary data analysis to assess the research. This research study on human-computer interaction conducted in China also discusses innovation and sports psychology. Human-computer interaction is the primary independent variable; it encompasses computer science, cognitive science, and human factor engineering, all regarded as independent variables. Innovation and sports psychology are viewed as dependent factors. This research is based on original data from assessing the outcome with intelligent PLS software and generating useful results. The correlation, R-square, F-square values, and weighted average analysis illustrate the intelligent PLS Algorithm model. The overall findings indicate that human-computer interaction has a favorable and significant effect on innovation and sports psychology. Computer science has direct effects on sports psychology as well. Cognitive science has a close relationship with innovation and sports psychology.(AU)

The impact of virtual reality and augmented reality on sport psychology

The essential aim of this research study is to measure the effect of virtual reality and augmented reality on sport psychology. This research study based on the quantitative research and data based on primary data analysis. For this purpose, generate different questions related to the variables the virtual reality and augmented reality both are consider as independent variable the sport psychology is main dependent variable. This research study employed smart PLS software to run distinct outcomes connected to the indicators and it was based on primary data analysis. The R square, composite reliability, discriminant validity, the indicator correlation, the total effect analysis and smart PLS Algorithm model present the overall research study. The virtual reality and augmented reality both are play a vital role in sport psychology. According to the result the overall research founded that there are positive and significant impact of virtual reality and augmented reality on the sport psychology.(AU)

The impact of Sports Activities on Economic Survival, Social Life of Women, and What do Big Data Analysis reveals about Social Life of Sports Women / El impacto de las actividades deportivas en la supervivencia económica, la vida social de las mujeres y qué revela el análisis de Big Data sobre la vida social de las mujeres deportistas

Economic Survival and Social Support in Sports activities is a multifaceted area of research interest. Active participation of women in sports activities has a significant contribution to the growth and success of the sports industry. This article seeks to discuss the impact of sports activities on sportswomen's economic survival and social life. This is done using questionnaire themed around issues such lack of availability of time, limitations of knowledge, family-related and financial difficulties, and nature of activities, all of which can potentially impact the social life of sportswomen. The study shows that economic survival is a significant part of sport's activities as well as the social life of sportswomen. Economic survival supports the social life of sportswomen. The current article highlights the findings from big data analysis pertaining to the social life of sportswomen. The paper uses Big Data Analysis to examine the social life of sportswomen. However, BDA is a complex process resulting from data sources' diverse and unstructured nature. Big Data Analysis (BDA) is critical in the sports field, as it covers the data at the macro-level (such as the national sports industry, teams, and individuals). It was analyzed using the AMOS 23v and SPSS 26v after being collected from female sports players belonging to a geographically diverse region. The study found that there is a significant association between sports activities, economic survival, and the social life of sportswomen.(AU)