Prevalence and factors associated with food insecurity in quilombola families from Alagoas, Brazil / Prevalência e fatores associados à Insegurança Alimentar em famílias das comunidades quilombolas de Alagoas, Brasil

ABSTRACT Objective This study aimed identify the prevalence and factors associated with food insecurity in families from the remaining quilombola communities in Alagoas, Brazil. Methods This is a cross-sectional study involving families residing in a random sample of 34 out of the 68 quilombola communities in Alagoas. The dependent variable was food insecurity, defined by the Brazilian Food Insecurity Scale, and its association (prevalence ratio - PR and 95% CI) with the independent variables (socioeconomic, demographic, and environmental) was assessed through multivariable analysis (Poisson regression with robust variance adjustment). Results A total of 2,485 families were evaluated, of which 67.6% were experiencing food insecurity (32.9% mild, 20.1% moderate, and 14.6% severe). Variables associated with moderate + severe forms were: improper waste disposal other than public collection; households with ≤4 rooms; using inadequate water for consumption; households with >4 residents; with residents <18 years old; low educational level of the head of the family (≤8 years); belonging to the lower economic class (D-E); and being a beneficiary of the Bolsa Família Program. Conclusion Food insecurity affects more than two-thirds of quilombola families in Alagoas, constituting an expressive public health problem. In its more severe forms (moderate+severe), it is associated with worse environmental, socioeconomic, and demographic conditions.

RESUMO Objetivo Identificar a prevalência e os fatores associados à insegurança alimentar em famílias das comunidades remanescentes de quilombos de Alagoas, Brasil. Métodos Trata-se de um estudo transversal, envolvendo as famílias residentes em amostra aleatória de 34 dentre as 68 comunidades quilombolas alagoanos. A variável dependente foi a insegurança alimentar, definida pela Escala Brasileira de Insegurança Alimentar, e sua associação (razão de prevalência e intervalo de confiança 95%) com as variáveis independentes (socioeconômicas, demográficas e ambientais) foi verificada por análise multivariável, (regressão de Poisson com ajuste robusto da variância). Resultados Foram avaliadas 2.485 famílias, das quais 67,6% estavam em insegurança alimentar (32,9% leve, 20,1% moderada e 14,6% grave). As variáveis associadas às formas moderada e grave foram: destinação do lixo diferente de coleta pública; domicílios com ≤4 cômodos; utilização de água inadequada para consumo; domicílios com >4 moradores; com moradores <18 anos; baixa escolaridade do chefe da família (≤8 anos); pertencer à classe econômica inferior (D-E) e; ser usuário do Programa Bolsa Família. Conclusão A insegurança alimentar atinge mais de dois terços das famílias quilombolas alagoanas, configurando-se num importante problema de saúde pública. Em suas formas mais intensas (moderada e grave), associa-se a piores condições ambientais, socioeconômicas e demográficas.

Ultra-processed food consumption and metabolic syndrome: a cross-sectional study in Quilombola communities of Alagoas, Brazil.

BACKGROUND: The processing of food can cause changes that turn them into risk factors for chronic diseases. A higher degree of food processing is associated with the development of chronic non-communicable diseases (NCDs), including the metabolic syndrome (MetS). The objective of this study was to analyze the relationship between ultra-processed food (UPF) consumption and the prevalence of MetS and its risk factors, focusing on a population group especially subjected to precarious living conditions and food insecurity. METHOD: Cross-sectional population-based study with women (19 to 59 years) from Quilombola communities of Alagoas. The socioeconomic, demographic, anthropometric, health status, lifestyle, and food intake (24-h recall) variables were analyzed. The dependent variable was the MetS, defined using the harmonization criteria of the Joint Interim Statement, and its components. The foods consumed were categorized according to the Nova Classification, assuming the highest UPF consumption as risk exposure. The measure of association was the prevalence ratio (PR) and respective 95%CI, calculated by Poisson regression with robust variance. We also analyzed the association with the Nova score of UPF consumption. RESULTS: We investigated 895 women (38.9 ± 11.0 years), of whom 48.3% had MetS. On average, 15.9% of the total energy intake came from UPF. Lower Nova scores were associated with a lower prevalence of diabetes and low HDL. Higher UPF consumption was associated with a 30% higher prevalence of hypertension (PR = 1.30; 95%CI: 1.06-1.61). CONCLUSION: The highest UPF consumption was positively associated with the prevalence of hypertension, while a lower Nova score was a protective factor against diabetes and low HDL. UPF consumption in Quilombola communities is important but lower than that observed in the Brazilian population in general. It is suggested that public health programs be implemented to promote healthy eating while valuing the existing eating habits and traditions among the remaining Brazilian Quilombola people.

RESUMO: INTRODUçãO: O processamento de alimentos pode causar alterações que os transformam em fatores de risco para doenças crônicas. Um maior grau de processamento de alimentos está associado ao desenvolvimento de doenças crônicas não transmissíveis (DCNT), incluindo a síndrome metabólica (SM). O objetivo deste estudo foi analisar a relação entre o consumo de alimentos ultraprocessados (AUP) e a prevalência de SM e seus fatores de risco, com foco em um grupo populacional especialmente submetido a precárias condições de vida e insegurança alimentar. MéTODO: Estudo transversal de base populacional com mulheres (19 a 59 anos) de comunidades Quilombolas de Alagoas. Foram analisadas as variáveis socioeconômicas, demográficas, antropométricas, estado de saúde, estilo de vida e ingestão alimentar (recordatório de 24 horas). A variável dependente foi a SM, definida a partir dos critérios de harmonização do Joint Interim Statement, e seus componentes. Os alimentos consumidos foram categorizados de acordo com a Classificação Nova, assumindo como exposição de risco o maior consumo de AUP. A medida de associação foi a razão de prevalência (RP) e respectivo IC 95%, calculado por regressão de Poisson com variância robusta. Também analisou-se a associação com o Escore Nova de consumo de AUP. RESULTADOS: Foram investigadas 895 mulheres (38,9 ± 11,0 anos), das quais 48,3% tinham SM. Em média, 15,9% da ingestão total de energia provinham de AUP. Escores Nova mais baixos foram associados a uma menor prevalência de diabetes e HDL baixo. O maior consumo de AUP se associou a uma prevalência 30% maior de hipertensão arterial (RP = 1,30; IC95%: 1,06-1,61). CONCLUSãO: O maior consumo de AUP se associou positivamente à prevalência de hipertensão, enquanto o menor escore Nova foi fator de proteção contra diabetes e baixo HDL. O consumo de AUP nas comunidades Quilombolas é relevante, mas inferior ao observado na população brasileira em geral. Sugere-se a implementação de programas de saúde pública que promovam a alimentação saudável, valorizando os hábitos e tradições alimentares existentes entre os remanescentes Quilombolas brasileiros.

Hemorrhagic prostatic cyst in a dog - case report.

We present the case of a five-year-old intact mixed breed male dog with hemorrhagic prostatic cysts. The patient presented with hematuria, dysesthesia, and pain on abdominal palpation. Abdominal ultrasound, hematology, urinalysis, and biochemical evaluation tests were subsequently conducted. Laboratory tests revealed cloudy urine with bacteria, and countless red blood cells. On ultrasound examination, the prostate was severely enlarged, with heterogeneous and reduced parenchyma, surrounding a large cavity filled with anechoic material with moderate cellularity. The urinary bladder was markedly distended and had a round, hypoechogenic structure in the lumen. The patient was hospitalized and had significant, irreversible worsening of the clinical symptoms and died. Subsequently, necropsy of the patient was performed and a histopathological diagnosis of benign prostatic hyperplasia associated with the presence of a prostatic hemorrhagic cyst, prostatitis, and chronic cystitis with an intraluminal blood clot was made. To the best of our knowledge, this is the first report to describe the occurrence of a hemorrhagic cyst in a canine prostate, thus bringing important information from clinical and imaging findings to the veterinary routine.

Apresentamos o caso de um cão macho de cinco anos de idade sem raça definida com cisto prostático hemorrágico. O paciente manifestava hematúria, disquesia e dor à palpação abdominal. Foram realizadas ultrassonografias abdominais subsequentes, hematologia, urinálise e testes de avaliação bioquímica. Os testes laboratoriais revelaram urina turva com bactérias e inúmeros glóbulos vermelhos. No exame ultrassonográfico, a próstata estava severamente aumentada, com parênquima heterogêneo e reduzido, circundando uma grande cavidade cheia de material anecoico com celularidade moderada. A bexiga urinária estava marcadamente distendida e tinha uma estrutura redonda e hipoecogênica no lúmen. O paciente foi internado e teve um agravamento significativo e irreversível dos sintomas clínicos e veio a óbito. Subsequentemente, foi realizada a necropsia do paciente e foi feito o diagnóstico histopatológico de hiperplasia prostática benigna associada à presença de um cisto hemorrágico prostático, prostatite e cistite crônica com um coágulo sanguíneo intraluminal. Tanto quanto sabemos, este é o primeiro relatório descrevendo a ocorrência de um cisto hemorrágico numa próstata canina, trazendo assim informações importantes dos resultados clínicos e de imagem para a rotina veterinária.

Múltiplos efeitos da pandemia de Covid-19 no contexto do transplante de órgãos no Brasil e no mundo / Multiple effects of the Covid-19 in the context of organ transplantation in Brazil and around the world

Introdução: Este artigo apresenta uma revisão literária do impacto dos transplantes de órgãos no contexto da pandemia de Covid-19. Esse período gerou desafios significativos para os programas de transplantes em todo o mundo, afetando a disponibilidade de órgãos, a segurança dos receptores, dos doadores e de recursos médicos. Objetivos: Realizar um levantamento dos aspectos relacionados aos impactos da pandemia de Covid-19 em torno do processo de transplantes. Método: Foi feita uma revisão sistemática com busca de artigos nas bases do PubMed, SciELO e LILACS, março de 2020 a fevereiro de 2023. Os descritores foram utilizados de forma combinada: "Covid-19", "Transplante de órgãos (Organ transplant)" e "Impacto (Impact)". Resultados: Foram encontrados 24 artigos. Diante da emergência da situação provocada pela síndrome respiratória aguda causada pela Covid-19, houve ocupação de unidades de terapia intensiva (UTI), gerando indisponibilidade de leitos para pacientes transplantados. O número de transplantes sofreu decréscimo diante dos impactos da pandemia de Covid-19. Conclusões: A pandemia de Covid-19 impactou os receptores de órgãos na diminuição de transplantes e doação de órgãos, repercutindo nos aspectos emocionais e psicológicos dos pacientes e de suas famílias, bem como dos profissionais de saúde, cujo desafio é garantir a continuidade dos procedimentos. Nota-se a importância da promoção de políticas públicas que favoreçam a melhor organização e disponibilidade de leitos para a realização de transplantes.

Introduction: This article presents an literary review of the organ transplant impact in the Covid-19 pandemic scenario. Organ transplant programs all over the world faced serious challenges during this period, affecting the tissue and organ availability, safety of the receptors, donors and the medical resources. Objective: Perform a withdrawal of the aspects related to the impacts of Covid-19 pandemic in the context of tissue and organ procurement. Method: Was made a systematic review with research in the databases of PubMed, SciELO and LILACS, from March 2020 to February 2023. The descriptors used in a combined manner were: Covid-19, organ transplant and impact. Results: 24 articles were found. Facing the acute respiratory syndrome emergency caused by the Covid-19, intensive care units (ICU) were occupied, resulting in a unavailability of beds to the transplant patients. The number of transplants suffered a decrease in front of Covid-19 pandemic. Conclusion: The Covid-19 pandemic impacted the organ receptors according to the transplantation and organ donation decrease, reflecting in emotional and psychological aspects of patients and their family, as well as healthcare professionals, whose challenge is to ensure the continuity of procedures. It is noticed the importance in promoting public policies that favor better organization and availability of beds for transplantation

Mobilização passiva precoce aumenta a resposta de reatividade vascular em pacientes graves com sepse: um estudo quase-experimental / Early passive mobilization increases vascular reactivity response in critical patients with sepsis: a quasi-experimental study

RESUMO Objetivo: Investigar a influência de uma sessão de mobilização passiva na função endotelial de pacientes com sepse. Métodos: Este foi um estudo quase-experimental duplo-cego e de braço único com desenho pré e pós-intervenção. Participaram 25 pacientes com diagnóstico de sepse hospitalizados em unidade de terapia intensiva. Avaliou-se a função endotelial basal (pré-intervenção) e imediatamente pós-intervenção por meio de ultrassonografia da artéria braquial. Foram obtidas a dilatação mediada pelo fluxo, a velocidade pico de fluxo sanguíneo e a taxa de cisalhamento pico. A mobilização passiva consistiu na mobilização bilateral (tornozelos, joelhos, quadris, pulsos, cotovelos e ombros), com três séries de dez repetições cada, totalizando 15 minutos. Resultados: Após a mobilização, encontramos aumento da função de reatividade vascular em relação à pré-intervenção: dilatação mediada pelo fluxo absoluta (0,57mm ± 0,22 versus 0,17mm ± 0,31; p < 0,001) e dilatação mediada pelo fluxo relativa (17,1% ± 8,25 versus 5,08% ± 9,16; p < 0,001). O pico de fluxo sanguíneo na hiperemia (71,8cm/s ± 29,3 versus 95,3cm/s ± 32,2; p < 0,001) e a taxa de cisalhamento (211s ± 113 versus 288s ± 144; p < 0,001) também aumentaram. Conclusão: Uma sessão de mobilização passiva foi capaz de aumentar a função endotelial em pacientes graves com sepse. Estudos futuros são necessários para investigar se um programa de mobilização pode ser aplicado como intervenção benéfica para melhorar clinicamente a função endotelial em pacientes hospitalizados por sepse.

ABSTRACT Objective: To investigate the influence of a passive mobilization session on endothelial function in patients with sepsis. Methods: This was a quasi-experimental double-blind and single-arm study with a pre- and postintervention design. Twenty-five patients with a diagnosis of sepsis who were hospitalized in the intensive care unit were included. Endothelial function was assessed at baseline (preintervention) and immediately postintervention by brachial artery ultrasonography. Flow mediated dilatation, peak blood flow velocity and peak shear rate were obtained. Passive mobilization consisted of bilateral mobilization (ankles, knees, hips, wrists, elbows and shoulders), with three sets of ten repetitions each, totaling 15 minutes. Results: After mobilization, we found increased vascular reactivity function compared to preintervention: absolute flow-mediated dilatation (0.57mm ± 0.22 versus 0.17mm ± 0.31; p < 0.001) and relative flow-mediated dilatation (17.1% ± 8.25 versus 5.08% ± 9.16; p < 0.001). Reactive hyperemia peak flow (71.8cm/s ± 29.3 versus 95.3cm/s ± 32.2; p < 0.001) and shear rate (211s ± 113 versus 288s ± 144; p < 0.001) were also increased. Conclusion: A passive mobilization session increases endothelial function in critical patients with sepsis. Future studies should investigate whether a mobilization program can be applied as a beneficial intervention for clinical improvement of endothelial function in patients hospitalized due to sepsis.

Targeting C5aR1 signaling reduced neutrophil extracellular traps and ameliorates COVID-19 pathology

Patients with severe COVID-19 develop acute respiratory distress syndrome (ARDS) that may progress to cytokine storm syndrome, organ dysfunction, and death. Considering that complement component 5a (C5a), through its cellular receptor C5aR1, has potent proinflammatory actions, and plays immunopathological roles in inflammatory diseases, we investigated whether C5a/C5aR1 pathway could be involved in COVID-19 pathophysiology. C5a/C5aR1 signaling increased locally in the lung, especially in neutrophils of critically ill COVID-19 patients compared to patients with influenza infection, as well as in the lung tissue of K18-hACE2 Tg mice (Tg mice) infected with SARS-CoV-2. Genetic and pharmacological inhibition of C5aR1 signaling ameliorated lung immunopathology in Tg-infected mice. Mechanistically, we found that C5aR1 signaling drives neutrophil extracellular trap (NET)s-dependent immunopathology. These data confirm the immunopathological role of C5a/C5aR1 signaling in COVID-19 and indicate that antagonist of C5aR1 could be useful for COVID-19 treatment.

CASP4/11 contributes to pulmonary inflammation and disease exacerbation in COVID-19

Infection with SARS-CoV-2 induces COVID-19, an inflammatory disease that is usually self-limited, but depending on patient conditions may culminate with critical illness and patient death. The virus triggers activation of intracellular sensors, such as the NLRP3 inflammasome, which promotes inflammation and aggravates the disease. Thus, identification of host components associated with NLRP3 inflammasome is key for understanding the physiopathology of the disease. Here, we reported that SARS-CoV-2 induces upregulation and activation of human Caspase-4/CASP4 (mouse Caspase-11/CASP11) and this process contributes to inflammasome activation in response to SARS-CoV-2. CASP4 was expressed in lung autopsy of lethal cases of COVID-19 and CASP4 expression correlates with expression of inflammasome components and inflammatory mediators such as CASP1, IL1B, IL18 and IL6. In vivo infections performed in transgenic hACE2 humanized mouse, deficient or sufficient for Casp11, indicate that hACE2 Casp11-/- mice were protected from disease development, with reduced body weight loss, reduced temperature variation, increased pulmonary parenchymal area, reduced clinical score of the disease and reduced mortality. Collectively, our data establishes that CASP4/11 contributes to disease pathology and contributes for future immunomodulatory therapeutic interventions to COVID-19.

Patterns of vascular response immediately after passive mobilization in patients with sepsis: an observational transversal study.

Sepsis is a serious organ dysfunction leading to endothelial damage in critical patients. Physiologically, there is an augment of vascular diameter in response to increased vascular blood flow and shear stress stimulus. However, the pattern of vascular response in face of passive mobilization (PM), an early mobilization physical strategy, has not yet been explored in patients with sepsis. To explore patterns of vascular response to PM and associations with clinical and cardiovascular profile in patients with sepsis. Cross-sectional, single-arm study. Thirty-two patients diagnosed with sepsis were enrolled. Vascular response was assessed by flow-mediated dilation (FMD) using brachial artery ultrasound, before and after PM. The PM (to assess the response pattern) and SR (shear rate) were also calculated. PM protocol consisted of knees, hips, wrists, elbows, shoulders, dorsiflexion/plantar flexion movements 3 × 10 repetitions each (15 min). Arterial stiffness was assessed by Sphygmocor®, by analyzing the morphology and pulse wave velocity. Cardiac autonomic modulation (CAM) was assessed by analyzing heart rate variability indexes (mean HR, RMSSD, LF, HF, ApEn, SampEn, DFA). Different vascular responses were observed after PM: (1) increased vascular diameter (responders) (n = 13, %FMD = 11.89 ± 5.64) and (2) reduced vascular diameter (non-responders) (n = 19, %FMD= -7.42 ± 6.44). Responders presented a higher non-linear DFA2 index (p = 0.02). There was a positive association between FMD and DFA (r = 0.529; p = 0.03); FMD and SampEn (r = 0.633; p < 0.01). A negative association was identified between FMD and LF (Hz) (r= -0.680; p < 0.01) and IL-6 (r= -0.469; p = 0.037) and SR and CRP (r= -0.427; p = 0.03).

Early passive mobilization increases vascular reactivity response in critical patients with sepsis: a quasi-experimental study. / Mobilização passiva precoce aumenta a resposta de reatividade vascular em pacientes graves com sepse: um estudo quase-experimental.

OBJECTIVE: To investigate the influence of a passive mobilization session on endothelial function in patients with sepsis. METHODS: This was a quasi-experimental double-blind and single-arm study with a pre- and postintervention design. Twenty-five patients with a diagnosis of sepsis who were hospitalized in the intensive care unit were included. Endothelial function was assessed at baseline (preintervention) and immediately postintervention by brachial artery ultrasonography. Flow mediated dilatation, peak blood flow velocity and peak shear rate were obtained. Passive mobilization consisted of bilateral mobilization (ankles, knees, hips, wrists, elbows and shoulders), with three sets of ten repetitions each, totaling 15 minutes. RESULTS: After mobilization, we found increased vascular reactivity function compared to preintervention: absolute flow-mediated dilatation (0.57mm ± 0.22 versus 0.17mm ± 0.31; p < 0.001) and relative flow-mediated dilatation (17.1% ± 8.25 versus 5.08% ± 9.16; p < 0.001). Reactive hyperemia peak flow (71.8cm/s ± 29.3 versus 95.3cm/s ± 32.2; p < 0.001) and shear rate (211s ± 113 versus 288s ± 144; p < 0.001) were also increased. CONCLUSION: A passive mobilization session increases endothelial function in critical patients with sepsis. Future studies should investigate whether a mobilization program can be applied as a beneficial intervention for clinical improvement of endothelial function in patients hospitalized due to sepsis.

OBJETIVO: Investigar a influência de uma sessão de mobilização passiva na função endotelial de pacientes com sepse. MÉTODOS: Este foi um estudo quase-experimental duplo-cego e de braço único com desenho pré e pós-intervenção. Participaram 25 pacientes com diagnóstico de sepse hospitalizados em unidade de terapia intensiva. Avaliou-se a função endotelial basal (pré-intervenção) e imediatamente pós-intervenção por meio de ultrassonografia da artéria braquial. Foram obtidas a dilatação mediada pelo fluxo, a velocidade pico de fluxo sanguíneo e a taxa de cisalhamento pico. A mobilização passiva consistiu na mobilização bilateral (tornozelos, joelhos, quadris, pulsos, cotovelos e ombros), com três séries de dez repetições cada, totalizando 15 minutos. RESULTADOS: Após a mobilização, encontramos aumento da função de reatividade vascular em relação à pré-intervenção: dilatação mediada pelo fluxo absoluta (0,57mm ± 0,22 versus 0,17mm ± 0,31; p < 0,001) e dilatação mediada pelo fluxo relativa (17,1% ± 8,25 versus 5,08% ± 9,16; p < 0,001). O pico de fluxo sanguíneo na hiperemia (71,8cm/s ± 29,3 versus 95,3cm/s ± 32,2; p < 0,001) e a taxa de cisalhamento (211s ± 113 versus 288s ± 144; p < 0,001) também aumentaram. CONCLUSÃO: Uma sessão de mobilização passiva foi capaz de aumentar a função endotelial em pacientes graves com sepse. Estudos futuros são necessários para investigar se um programa de mobilização pode ser aplicado como intervenção benéfica para melhorar clinicamente a função endotelial em pacientes hospitalizados por sepse.

The effect of passive mobilization associated with blood flow restriction and combined with electrical stimulation on cardiorespiratory safety, neuromuscular adaptations, physical function, and quality of life in comatose patients in an ICU: a randomized controlled clinical trial.

BACKGROUND: Intensive care unit-acquired atrophy and weakness are associated with high mortality, a reduction in physical function, and quality of life. Passive mobilization (PM) and neuromuscular electrical stimulation were applied in comatose patients; however, evidence is inconclusive regarding atrophy and weakness prevention. Blood flow restriction (BFR) associated with PM (BFRp) or with electrical stimulation (BFRpE) was able to reduce atrophy and increase muscle mass in spinal cord-injured patients, respectively. Bulky venous return occurs after releasing BFR, which can cause unknown repercussions on the cardiovascular system. Hence, the aim of this study was to investigate the effect of BFRp and BFRpE on cardiovascular safety and applicability, neuromuscular adaptations, physical function, and quality of life in comatose patients in intensive care units (ICUs). METHODS: Thirty-nine patients will be assessed at baseline (T0-18 h of coma) and randomly assigned to the PM (control group), BFRp, or BFRpE groups. The training protocol will be applied in both legs alternately, twice a day with a 4-h interval until coma awake, death, or ICU discharge. Cardiovascular safety and applicability will be evaluated at the first training session (T1). At T0 and 12 h after the last session (T2), muscle thickness and quality will be assessed. Global muscle strength and physical function will be assessed 12 h after T2 and ICU and hospital discharge for those who wake up from coma. Six and 12 months after hospital discharge, physical function and quality of life will be re-assessed. DISCUSSION: In view of applicability, the data will be used to inform the design and sample size of a prospective trial to clarify the effect of BFRpE on preventing muscle atrophy and weakness and to exert the greatest beneficial effects on physical function and quality of life compared to BFRp in comatose patients in the ICU. TRIAL REGISTRATION: Universal Trial Number (UTN) Registry UTN U1111-1241-4344. Retrospectively registered on 2 October 2019. Brazilian Clinical Trials Registry (ReBec) RBR-2qpyxf . Retrospectively registered on 21 January 2020, http://ensaiosclinicos.gov.br/rg/RBR-2qpyxf/.

Common Mental Disorder and early interruption of exclusive maternal breastfeeding in Quilombola women: a population-based study / Transtorno mental comum e interrupção precoce do aleitamento materno exclusivo em mulheres quilombolas: estudo de base populacional

Abstract Objectives: to investigate the prevalence of exclusive maternal breastfeeding (EMBF) and evaluate whether common mental disorder (CMD) and other predictors promote its early interruption (EI-EMBF4). Methods: a cross-sectional study involving all children <24 months (n=252) residing in 50% (n=34) of the Quilombola communities in Alagoas. The EI-EMBF4 was established when EMBF was ≤4 months. The Self-Reporting Questionnaire was used to identify the occurrence of CMD. Other predictors were obtained through interviews. The measure of association was the prevalence ratio calculated by the Poisson regression, following a hierarchical theoretical model. The prevalence of EMBF for 4 and 6 months, and its median duration (survival analysis) were calculated. Results: the prevalence of EI-EMBF4 and CMD was 57.6% and 42.9%, respectively. The risk factors independently associated with EI-EMBF4 were: living in a mud house, maternal age ≤18 years, low birth weight and the use of a pacifier or baby bottle. There was no association with CMD. The prevalence of EMBF for four and six months was 42.4% and 25.4%, respectively, and the median duration was 106 days. Conclusion: EMBF indicators are below the established recommendations, justifying the implementation of measures that prioritize women subjected to risk factors identified here. CMD is not configured among these.

Resumo Objetivos: investigar a prevalência do aleitamento materno exclusivo (AME) e se o transtorno mental comum (TMC) e outros preditores promovem sua interrupção precoce (IP- AME4). Métodos: estudo transversal envolvendo todas as crianças <24 meses (n=252) residentes em 50% (n=34) das comunidades quilombolas de Alagoas. A IP-AME4 foi definida quando o AME foi ≤ 4 meses. Utilizou-se o Self-Reporting Questionnaire para identificar o TMC. Outros preditores foram obtidos por meio de entrevista. A medida de associação foi a razão de prevalência calculada por regressão de Poisson, seguindo modelo teórico hierárquico. Foram calculadas as prevalências de AME por 4 e 6 meses e sua duração mediana (análise de sobrevivência). Resultados: as prevalências de IP-AME4 e do TMC foram 57,6% e 42,9%, respectivamente. Os fatores de risco independentemente associados à IP-AME4 foram: residir em casa de taipa, idade materna ≤18 anos, baixo peso ao nascer e uso de chupeta ou de mamadeira. Não houve associação com TMC. As prevalências do AME por quatro e por seis meses foram 42,4% e 25,4%, nessa ordem, e a duração mediana foi de 106 dias. Conclusão: os indicadores de AME estão aquém das metas estabelecidas, justificando a implementação de medidas que atuem sobre os fatores de risco aqui identificados, sendo que o TMC não se configura entre esses.

Prevalence of IGFBP3, NOS3 and TCF7L2 polymorphisms and their association with hypertension: a population-based study with Brazilian women of African descent.

OBJECTIVE: African ancestry seems to be a risk factor for hypertension; however, few genetic studies have addressed this issue. This study aimed to investigate the prevalence of polymorphisms NOS3; rs1799983, IGFBP3; rs11977526 and TCF7L2; rs7903146 in Brazilian women of African descent and their association with hypertension. RESULTS: The prevalences of the less frequent genotypes were 26.5% TT genotype of NOS3; rs1799983, 16.7% AA genotype of IGFBP3; rs11977526, and 18.3% TT genotype of TCF7L2; rs7903146. For these conditions, the prevalence of hypertension and PR (adjusted) relatively to the ancestral genotype were, respectively: 52.0% vs 24.5% (PR = 1.54; p < 0.001), 62.0% vs 24.1% (PR = 1.59; p < 0.001), and 38.9% vs 27.9% (PR = 0.86; p = 0.166). Associations with hypertension were statistically significant, except for the TCF7L2; rs7903146 polymorphism, after adjusted analysis. Brazilian Afro-descendant women with the TT genotype for the NOS3 gene and the AA genotype for the IGFBP3 gene are more susceptible to hypertension. The understanding of underlying mechanisms involving the pathogenesis of hypertension can motivate research for the development of new therapeutic targets related to nitric oxide metabolism and the management of oxidative stress.

Factors associated with childhood anaemia in Afro-descendant communities in Alagoas, Brazil.

OBJECTIVE: To investigate factors associated with anaemia in preschool children. DESIGN: A home survey was conducted in 2018. Anaemia in children (capillary blood Hb level < 110 g/l) was the outcome, and socio-economic, demographic and health factors of the mother and child were the independent variables. The measure of association was the prevalence ratio, and its 95 % CI was calculated using Poisson's regression with robust variance and hierarchical selection of independent variables. SETTING: Afro-descendants communities living in the state of Alagoas, northeast Brazil. PARTICIPANTS: Children aged 6-59 months and their mothers (n 428 pairs). RESULTS: The prevalence of child anaemia was 38·1 % (95 % CI 33·5, 42·7). The associated factors with child anaemia were male sex, age < 24 months, larger number of residents at home (> 4), relatively taller mothers (highest tertile) and higher z-score of BMI for age, after further adjustment for wealth index, vitamin A supplementation in the past 6 months and clinical visit in the last 30 d. CONCLUSIONS: The high prevalence of anaemia observed reveals a relevant public health problem amongst children under five from the quilombola communities of Alagoas. Considering the damage caused to health and multiplicity of risk factors associated with anaemia, the adoption of intersectoral strategies that act on modifiable risk factors and increase vigilance concerning those that are not modifiable becomes urgent.

Stunting and overweight among children in Northeast Brazil: prevalence, trends (1992-2005-2015) and associated risk factors from repeated cross-sectional surveys.

BACKGROUND: A study involving children from Alagoas (Northeast Brazil) revealed that, as a consequence of a drastic reduction in the prevalence of stunting between 1992 to 2005, (22.5 to 11.4%) combined with an increase in overweight prevalence (6.7 to 9.3%), the prevalence of these two conditions in 2005 was very close. If these trends were maintained, it is very likely that, at this time, the childhood overweight prevalence has already exceeded that of the stunting. However, no study is available to confirm this hypothesis. The identification of these changes is relevant to the planning and evaluation of public policies. This study aimed to investigate the prevalence, time trends and associated factors with stunting and overweight in children from Alagoas. METHODS: Independent cross-sectional household surveys were conducted in 1992 (n = 1231), 2005 (n = 1381) and 2015 (n = 988). Data were collected from probabilistic samples of children aged 0-60 months. Stunting was defined by stature-for-age < - 2 sd and overweight by weight-for-stature > 2 sd. RESULTS: Between 1992, 2005 and 2015, the stunting prevalence was 22.6, 11.2 and 3.2% (reduction of 85.8%), while the overweight prevalence was 6.9, 7.5 and 14.9% (increase of 115.9%), respectively. After multivariate analysis, the following positive associations with stunting were observed in 1992: age group > 24 months (28.3% vs 14.5%), mother with ≥2 children (28.8% vs 12.8%), low birth weight (28.3% vs 15.7%) and mother with low schooling (29.3% vs 7.2%). In 2015 there was a higher prevalence of stunting in males (4.2% vs 2.2%), in children < 24 months (4.6% vs 2.2%), with low birth weight (8.6% vs 3.0%) and in those who had mothers with low schooling (7.0% vs 2.6%). Regarding overweight, in 1992 there was higher prevalence for male (9.1% vs 4.7%) and in children whose mothers had ≤2 children (8.9% vs 5.8%), while in 2015 only birth weight >  4 kg was associated to overweight (27.3% vs 14.2%). CONCLUSIONS: During the analyzed period, there was a significant decrease in stunting prevalence. At the same time, a substantial increase was observed in the overweight prevalence. Currently, stunting is a problem of low magnitude, while overweight has become a worrying public health problem.

Câncer de mama e imagem corporal: impacto dos tratamentos no olhar de mulheres mastectomizadas / Breast cancer and body image: impact of treatments from the point of view of mastectomized females

Esta pesquisa avaliou a percepção da imagem corporal de mulheres mastectomizadas, com ou sem reconstrução mamária, investigando como o adoecimento e os tratamentos impactaram suas vidas. Trata-se de um estudo descritivo, transversal, com abordagem qualitativa. Participaram dez mulheres com diagnóstico de câncer mamário, mastectomizadas, com ou sem reconstrução mamária, atendidas no HU/UFJF, de janeiro a novembro de 2015, por meio de uma entrevista semiestruturada. Para análise qualitativa, aplicou-se a Análise de Conteúdo de Bardin, de onde emergiram as categorias: "Diagnóstico e Enfrentamento", "Rede de Apoio", "Tratamentos e seus Anseios", "Imagem Corporal", e "Papel na Sociedade". Concluiu-se que o cuidado com a saúde das mulheres acometidas pela doença demanda assistência multiprofissional, que auxilie no processo de enfrentamento do câncer e na reabilitação para além das limitações físicas, com o intuito de reconexão do corpo físico, psíquico e espiritual, visando facilitar a adaptação ao "novo corpo" e permitir incremento na autoestima, a reinserção social e melhoria da qualidade de vida.

The perception of body image by mastectomized females, with or without breast reconstruction, is evaluated. Current descriptive, transversal and qualitative research analyzes how illness and treatments impacted their lives. Ten mastectomized females, diagnosed with breast cancer, attended at the University Hospital of UFJF, between January and November 2015, participated through a half-structured interview. Qualitative analysis comprised Bardin´s Content Analysis, from which were derived the categories: "Diagnosis and Coping", "Support Network", "Treatments and Anxiety", "Body Image", and "Role in Society". Results show that health care of ill females require multiprofessional assistance that helps them to cope with cancer and to rehabilitate them beyond physical limitations. The target is the reconnection of the physical, psychic and spiritual body, to facilitate the adaptation to the 'new body' and allow an increase in self-esteem, social reinsertion and improvement in life quality.

Noninvasive measurements of hemodynamic, autonomic and endothelial function as predictors of mortality in sepsis: A prospective cohort study.

BACKGROUND AND AIM: Sepsis is associated with marked alterations in hemodynamic responses, autonomic dysfunction and impaired vascular function. However, to our knowledge, analysis of noninvasive markers to identify greater risk of death has not yet been investigated. Thus, our aim was to explore the prognostic utility of cardiac output (CO), stroke volume (SV), indices of vagal modulation (RMSSD and SD1), total heart rate variability (HRV) indices and FMD of brachial artery (%FMD), all measured noninvasively, in the first 24 hours of the diagnosis of sepsis. METHODS: 60 patients were recruited at ICU between 2015 and 2017 and followed by 28 days. CO, SV, RR intervals were measurement. Doppler ultrasound was used to assess brachial artery FMD and the hyperemic response were obtained (%FMD). Patients were divided by survivors (SG) and nonsurvivors groups (NSG). RESULTS: A total of 60 patients were analysed (SG = 21 and NSG = 39). Survivors were younger (41±15 years vs. 55±11 years) and used less vasoactive drugs. As expected, APACHE and SOFA scores were lower in NSG compared to SG. In addition, higher SD1, triangular index, % FMD, velocity baseline and hyperemia flow velocity as well as lower HR values were observed in the SG, compared to NSG (P<0.05). Interestingly, RMSSD and SD1 indices were independent predictors of %FMD, ΔFMD and FMDpeak. RMSSD threshold of 10.8ms and %FMD threshold of -1 were optimal at discriminatomg survivors and nonsurvivors. CONCLUSION: Noninvasive measurements of autonomic and endotelial function may be important markers of sepsis mortality, which can be easily obtained in the early stages of sepsis at the bedside.

Prevalence and temporal trend (2005-2015) of anaemia among children in Northeast Brazil.

OBJECTIVE: Anaemia is the main nutritional deficiency in Brazil, and a prevention and control programme (National Program for Iron Supplementation) has been developed since 2005. Studies on the temporal evolution of anaemia prevalence contribute to assessment of the effectiveness of the actions undertaken. The present study aimed to identify the prevalence and temporal trend of anaemia in children. DESIGN: Study based on two cross-sectional household surveys carried out in 2005 and 2015. Anaemia was defined as Hb<11 g/dl (HemoCue®). Trend analysis was performed using the prevalence ratio (PR), calculated by Poisson regression with a robust adjustment of the variance. Differences were significant when P<0·05 in both crude analyses and those adjusted for possible confounding factors (e.g. socio-economic, demographic and health variables). SETTING: Alagoas, Brazil. SUBJECTS: In total, 666 and 782 children in the first and second Alagoas State Health and Nutrition Survey, respectively (probabilistic samples). RESULTS: In 2005 and 2015, anaemia prevalence was 45·1 and 27·4 %, respectively (-39·1 %; PR=0·61; 95 % CI 0·52, 0·70). In both surveys, children aged ≤24 months were more affected (P24 months (67·2 v. 40·7 %; 27·0 v. 19·3 %, respectively). CONCLUSIONS: The prevalence of anaemia reduced significantly in the evaluated period. Thus, it may no longer be a severe public health problem but can instead be considered a problem of moderate magnitude. It remains, however, above the level considered acceptable according to WHO criteria. These results justify the implementation of prevention and control actions.

Variability of susceptibility to deltamethrin in peridomestic Triatoma sordida from Triângulo Mineiro, State of Minas Gerais, Brazil.

INTRODUCTION: Despite chemical and physical vector control strategies, persistent infestations of Triatoma sordida have been reported in a large part of Minas Gerais, Brazil, and the cause for this is little investigated. We aimed to characterize the deltamethrin toxicological profile in peridomestic T. sordidapopulations from Triângulo Mineiro area of Minas Gerais. METHODS: Susceptibility to deltamethrin was assessed in seventeen peridomestic T. sordida populations. Serial dilutions of deltamethrin in acetone (0.2µL) were topically applied on the first instar nymphs (F1; five days old; fasting weight, 1.2 ± 0.2mg). Dose response results were analyzed using Probit software, and the lethal doses, slope and resistance ratios were determined. Qualitative tests were also performed. RESULTS: The deltamethrin susceptibility profile of T. sordida populations revealed resistance ratios ranging from 0.84 to 2.8. The percentage mortality in response to a diagnostic dose was 100.0% in all populations. CONCLUSIONS: From our results, the lack of resistance to insecticides but persistent T. sordida infestations in the Triângulo Mineiro area may be because of: 1) environmental degradation facilitating dispersion of T. sordida, allowing colonization in artificial ecotopes; 2) operational failures; and 3) complexity of the peridomicile in the study area.These variables are being investigated.

Variability of susceptibility to deltamethrin in peridomestic Triatoma sordida from Triângulo Mineiro, State of Minas Gerais, Brazil

Despite chemical and physical vector control strategies, persistent infestations of Triatoma sordida have been reported in a large part of Minas Gerais, Brazil, and the cause for this is little investigated. We aimed to characterize the deltamethrin toxicological profile in peridomestic T. sordidapopulations from Triângulo Mineiro area of Minas Gerais.

Efeitos das cepas probioticas de Lactobacillus acidophilus ATCC 4356, Lactobacillus rhamnosus ATCC 1465 e ATCC 7469 sobre o crescimento planctonico e formação de biofilme de Streptococcusmutans UA 159 / Probiotic strains Lactobacillus acidophilus ATCC 4356, Lactobacillus rhamnosus ATCC 1465 and ATCC 7469 effects on biofilm of Streptococcus mutans UA 159

A maioria das bactérias probióticas utilizadas em produtos comerciais são do gênero Lactobacillus. Entretanto, os efeitos das cepas probióticas de Lactobacillus na saúde bucal precisam ser mais investigados. Assim, o objetivo desse estudo foi avaliar os efeitos de cepas probióticas de Lactobacillus, sobre Streptococcus mutans. Foram testadas cepas de Lactobacillus acidophilus ATCC 4356, Lactobacillus rhamnosus ATCC 1465, Lactobacillus rhamnosus ATCC 7469 sobre o crescimento planctônico e biofilmes de Streptococcus mutans (UA159). Para estudo da atividade antibacteriana de Lactobacillus sobre o crescimento planctônico de S. mutans, suspensões padronizadas desses micro-organismos foram cultivadas em conjunto em caldo BHI por 24 h a 37 oC em 5% de CO2. Para estudo dos efeitos de Lactobacillus sobre biofilmes, suspensões padronizadas de cada cepa de Lactobacillus foram adicionadas aos biofilmes de S. mutans formados em fundo de placas de 96 poços. Os biofilmes foram incubados em Caldo BHI com 15% de sacarose a 37 oC por 48 h, e a seguir foram desagregados por homogeneização ultrassônica. Após a execução dos testes em crescimento planctônico e em biofilmes, foram realizadas diluições seriadas e semeaduras em meios de cultura seletivo para S. mutans (ágar Mitis Salivarius Bacitracina Sacarose) e para Lactobacillus (ágar Rogosa). A seguir, as unidades formadoras de colônias (UFC/mL) foram contadas e submetidas ao teste t de Student, considerando-se nível de significância de 5%. Os resultados demonstraram que as 3 cepas probioticas de Lactobacillus reduziram o crescimento planctônico de S. mutans, entretanto não foram observadas diferenças estatisticamente significantes entre os grupos Controle (S. mutans) e interação (S. mutans e cepa de Lactobacillus). Em relação aos biofilmes, apenas a cepa de Lactobacillus rhamnosus 1465 apresentou redução significativa no biofilme de S. mutans (p < 0,0001). Conclui-se que as cepas probióticas testadas não estimularam o ...

Most probiotic bacteria used in commercial products belong to the genus Lactobacillus. However, the effects of Lactobacillus probiotic strains in the oral health need to be further investigated. The objective of this study is to evaluate the effects of probiotic Lactobacillus strains, on Streptococcus mutans. Lactobacillus strains acidophilus ATCC 4356, Lactobacillus rhamnosus ATCC 1465, Lactobacillus rhamnosus ATCC 7469 were tested on planktonic and biofilm growth of Streptococcus mutans (UA159). In order to study the antimicrobial activity of Lactobacillus on planktonic growth of S. mutans, standardized suspensions of these microorganisms were grown together in BHI for 24 hours at 37 °C in 5% CO2. In order to study the antimicrobial activity on biofilm growth, standardized suspensions of each strain of Lactobacillus were added to the S. mutans biofilm formed on the bottom of 96 well plates. Biofilms were incubated in BHI broth with 15% sucrose at 37 °C for 48 h and then were separated by ultrasonic homogenization. After the tests with planktonic and biofilm growth, serial dilutions and sowing in selective culture media were performed for S. mutans (Mitis Salivarius Bacitracin Sucrose agar) and Lactobacillus (Rogosa agar). Subsequently, colony forming units (CFU / mL) were counted and submitted to the Student t test, considering a level of 5% significance. The results show that the 3 Lactobacillus probiotic strains reduced the planktonic growth of S. mutans, however, no significant statistical differences were observed between the control (S. mutans) and interaction groups (S. mutans and Lactobacillus strain). Regarding biofilm growth, only the strain of Lactobacillus rhamnosus 1465 showed a significant reduction of S. mutans biofilm (p < 0.0001). It was concluded that the probiotic strains tested do not stimulate the growth nor biofilm formation of S. mutans. Moreover, the Lactobacillus rhamnosus 1465 strain has shown the potential to be used as control ...