Mueller-Weiss disease: review of the literature.

Müller-Weiss (MW) disease is a spontaneous osteonecrosis of the tarsal navicular bone in adults. It is a rare cause of chronic medial midfoot pain and deformity characterized by the collapse of the dorso-lateral part of the navicular, progressive navicular fragmentation and talonavicular joint destruction. This study provides a review of the literature about the epidemiology, etio-pathogenesis, clinical, radiological findings and therapeutic alternatives.

Interleukin-6 gene polymorphism and risk of osteoarthritis of the hip: a case-control study.

OBJECTIVES: Osteoarthritis (OA) is considered a polygenic disease controlled by the expression of genetic factors. Genes encoding for cytokines have been associated with susceptibility for joint OA and interleukin (IL)-6 gene is also supposed to be involved in the cartilage degradation process. In this case-control study, we evaluated for the first time whether the risk of hip OA might be influenced by the -174 IL-6 gene polymorphism. METHODS: The distribution of IL-6 genotypes was evaluated in 75 patients affected by hip OA and in 107 age- and sex-matched controls. RESULTS: The distribution of IL-6 genotypes in (1) patients with hip OA: 33 GG, 30 GC, 12 CC and (2) control subjects: 34 GG, 40 GC, 33 CC. The frequency of the CC genotype was significantly higher in control patients (P=0.02). Logistic regression analysis indicated that the presence of the CC genotype is independently associated with a decreased risk of OA (odds ratio 0.4 [95% confidence interval 0.1-0.9], P=0.04). CONCLUSIONS: Primary OA of the hip has an important genetic component and variations of genes encoding for inflammatory cytokines, such as IL-6, may play an important role in the series of events responsible for the pathophysiology of OA.

The BeppoSAX View of the Hot Cluster Abell 2319.

We present results from a BeppoSAX observation of the rich cluster Abell 2319. The broadband spectrum (2-50 keV) of the cluster can be adequately represented by an optically thin thermal emission model with a temperature of 9.6+/-0.3 keV and a metal abundance of 0.25+/-0.03 in solar units and with no evidence of a hard X-ray excess in the PDS spectrum. From the upper limit to the hard-tail component, we derive a lower limit of approximately 0.04 µG for the volume-averaged intracluster magnetic field. By performing spatially resolved spectroscopy in the medium energy band (2-10 keV), we find that the projected radial temperature and metal abundance profiles are constant out to a radius of 16&arcmin; (1.4 Mpc). A reduction of the temperature of one-third, when going from the cluster core out to 16&arcmin;, can be excluded in the present data at the 99% confidence level. From the analysis of the temperature and abundance maps, we find evidence of a temperature enhancement and of an abundance decrement in a region localized 6&arcmin;-8&arcmin; northeast of the core, where a merger event may be taking place. Finally, the temperature map indicates that the subcluster located northwest of the main cluster may be somewhat cooler than the rest of the cluster.