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Higher resting heart rate variability (HRV)-an index of more flexible response to environmental stressors, including noxious stimuli-has been linked to reduced perception of experimentally induced pain. However, as stress responses are adapted to one's chronic environments, we propose that chronic exposure to threats captured by one's subjective socioeconomic status (SSS) may shape different adaptations that produce distinct pain responses linked to higher resting HRV. Specifically, lower SSS individuals with more threat exposures may prioritize threat detection by upregulating sensitivity to stressors, such as acute pain. Therefore, higher HRV would predict greater perceived acute pain among lower SSS individuals. In contrast, higher SSS individuals with less threat exposures may instead prioritize affective regulation by downregulating sensitivity to stressors, producing lower pain perception with higher HRV. We examined this stress response moderation by SSS in 164 healthy young adults exposed to experimental pain via the cold pressor test (CPT). Resting HRV, indexed by the root-mean-square of successive differences in heart rate, and self-reported SSS were measured at rest. Pain perception indexed by self-reported pain and pain tolerance indexed by hand-immersion time during the CPT were assessed. Results revealed that among higher SSS individuals, higher resting HRV predicted lower pain reports and subsequently greater pain tolerance during the CPT. Conversely, among lower SSS individuals, higher resting HRV predicted higher pain reports and subsequently lower pain tolerance. These findings provide preliminary evidence that environmental stress exposures linked to one's SSS may shape unique biological adaptations that predict distinct pain responses. Supplementary Information: The online version contains supplementary material available at 10.1007/s42761-023-00234-w.
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BACKGROUND: White matter hyperintensities (WMHs) represent diffuse small vessel disease implicating the cardiac, systemic, and cerebral vasculatures. As the brain may be the end-organ of cumulative vascular disease, and higher education is protective of both cardiovascular and brain health, we aim to clarify their intertwining relationships. METHODS: We evaluated participants (mean age = 64) from the UK Biobank with neuroimaging measures of WMHs, left ventricular ejection fraction (LVEF) quantified using cardiovascular MRI, and arterial stiffness index (ASI) quantified using finger photoplethysmography. We used multiple regression to evaluate the basic, independent, and interactive relationships of LVEF status (n = 27,512) and ASI (n = 33,584) with WMHs. Moderated mediation analysis was used to determine whether the relationship between LVEF status and WMH was mediated by ASI and moderated by education. RESULTS: Abnormal LVEF (ß = -0.082, p < 0.001) and higher ASI (ß = 0.02, p < 0.001) were associated with greater WMHs separately and independently, but not interactively. Moderated mediation analyses revealed that the relationship between abnormal LVEF and WMH was mediated by ASI, for individuals with lower education (ß = -0.004, p < 0.001). Abnormal LVEF was associated with lower cortical thickness in 16 predominantly frontotemporal and select parietal regions (FDR, q < 0.05). CONCLUSIONS: Cardiovascular dysfunction is associated with regional cerebral atrophy and may precipitate cerebrovascular disease via stiffening of systemic vasculatures, particularly for individuals with lower education. Integrative approaches to study biophysiological vascular systems can elucidate the complex interplay between biological and social determinants of brain and cerebrovascular health.
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Transtornos Cerebrovasculares , Rigidez Vascular , Humanos , Rigidez Vascular/fisiologia , Masculino , Feminino , Pessoa de Meia-Idade , Idoso , Transtornos Cerebrovasculares/fisiopatologia , Transtornos Cerebrovasculares/diagnóstico por imagem , Função Ventricular Esquerda/fisiologia , Volume Sistólico/fisiologia , Reino Unido/epidemiologia , Imageamento por Ressonância Magnética/métodosRESUMO
[This corrects the article DOI: 10.1007/s42761-023-00234-w.].
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There is increasing recognition that socioeconomic inequalities contribute to disparities in brain and cognitive health in older adults. However, whether neighborhood socioeconomic status (SES) buffers individuals with low individual SES against neurodegeneration, cerebrovascular disease, and poorer cognitive function is not well understood. Here, we evaluated whether neighborhood deprivation (Townsend deprivation index) interacted with individual SES (composite household income and education levels) on hippocampus volume, regional cortical thickness, white matter hyperintensities, and cognition in 19,638 individuals (mean age = 54.8) from the UK Biobank. We found that individuals with low individual SES had the smallest hippocampal volumes, greatest white matter hyperintensity burden, and poorest cognition if they were living in high deprivation neighborhoods but that these deleterious effects on brain and cognitive function were attenuated if they were living in low deprivation neighborhoods (p for interactions < .05). While neighborhood deprivation did not interact with individual SES to influence regional cortical thickness, higher neighborhood deprivation was independently associated with lower cortical thickness in 16 regions (false discovery rate q < .05). Across multiple brain indices and cognitive function analyses, we found converging evidence suggesting that low neighborhood deprivation may have a neuroprotective effect against neurodegeneration, cerebrovascular pathology, and cognitive impairment, particularly in vulnerable individuals with low household income and education levels.
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Substância Branca , Humanos , Idoso , Classe Social , Hipocampo , Cognição , EncéfaloRESUMO
The time period before, during and after pregnancy represents a unique opportunity for interventions to cultivate sustained healthy lifestyle behaviors to improve the metabolic health of mothers and their offspring. However, the success of a lifestyle intervention is dependent on uptake and continued compliance. To identify enablers and barriers towards engagement with a lifestyle intervention, thematic analysis of 15 in-depth interviews with overweight or obese women in the preconception, pregnancy or postpartum periods was undertaken, using the integrated-Promoting Action on Research Implementation in Health Services framework as a guide to systematically chart factors influencing adoption of a novel lifestyle intervention. Barrier factors include time constraints, poor baseline knowledge, family culture, food accessibility, and lack of relevant data sources. Enabling factors were motivation to be healthy for themselves and their offspring, family and social support, a holistic delivery platform providing desired information delivered at appropriate times, regular feedback, goal setting, and nudges. From the findings of this study, we propose components of an idealized lifestyle intervention including (i) taking a holistic life-course approach to education, (ii) using mobile health platforms to reduce barriers, provide personalized feedback and promote goal-setting, and (iii) health nudges to cultivate sustained lifestyle habits.
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Terapia Comportamental/métodos , Estilo de Vida Saudável , Entrevista Motivacional/métodos , Obesidade Materna/terapia , Período Pós-Parto , Cuidado Pré-Concepcional/métodos , Pesquisa Qualitativa , Adulto , Índice de Massa Corporal , Dieta Saudável/métodos , Exercício Físico , Feminino , Objetivos , Humanos , Gravidez , Apoio Social , Inquéritos e Questionários , Resultado do TratamentoRESUMO
There is a paucity of effective intervention tools for overweight/obese women to assess, guide and monitor their eating behavior. This study aimed to develop a lifestyle intervention tool, assess its acceptability and usefulness, and verify its construct validity in overweight/obese women. The 6P tool (Portion, Proportion, Pleasure, Phase, Physicality, Psychology) was developed and 15 women with a body mass index (BMI) ≥ 25 kg/m2 were interviewed to assess its perceived acceptability and usefulness. Subsequently, the revised 6P tool was tested in 46 women with a BMI ≥ 25 kg/m2. The Three-Factor Eating Questionnaire (TFEQ), International Physical Activity Questionnaire-Short (IPAQ), and weight were measured at baseline and one-month. Most participants were satisfied with the presentation of the 6P tool (86.8%), and agreed it was useful in guiding healthy eating (81.6%) and raising awareness of eating behavior (97.4%). There were significant improvements in cognitive restraint (p = 0.010) and disinhibition (p = 0.030) (TFEQ), portion size (P1), pleasure behaviors (P3), and total composite 6P score (p < 0.001). However, there was no significant reduction in weight or increase in physical activity. The 6P tool is acceptable and presents with good validity for assessing lifestyle behaviors.
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Comportamento Alimentar , Promoção da Saúde/normas , Estilo de Vida , Obesidade/terapia , Sobrepeso/terapia , Adulto , Índice de Massa Corporal , Dieta Saudável/métodos , Exercício Físico , Feminino , Humanos , Obesidade/psicologia , Sobrepeso/psicologia , Pesquisa Qualitativa , Inquéritos e Questionários/normas , Redução de PesoAssuntos
Ansiedade/psicologia , COVID-19/psicologia , Assistência Perioperatória/métodos , Assistência Perioperatória/psicologia , Equipamento de Proteção Individual , Adolescente , Ansiedade/prevenção & controle , COVID-19/prevenção & controle , Criança , Feminino , Humanos , Controle de Infecções/métodos , Masculino , Estudos ProspectivosRESUMO
BACKGROUND: Magnetic resonance (MRI) scanning of the heart is an established part of the investigation of cardiovascular conditions in children. In young children, sedation is likely to be needed, and multiple controlled periods of apnea are often required to allow image acquisition. Suppression of spontaneous ventilation is possible with remifentanil; however, the dose required is uncertain. AIMS: To establish the dose of remifentanil, by infusion, required to suppress ventilation sufficiently to allow a 30-s apnea during MRI imaging of the heart. METHOD: Patients aged 1-6 years were exposed to different doses of remifentanil, and the success in achieving a 30-s apnea was recorded. A dose recommendation was made for each patient, informed by responses of previous patients using an adaptive Bayesian dose-escalation design. Other aspects of anesthesia were standardized. A final estimate of the dose needed to achieve a successful outcome in 80% of patients (ED80) was made using logistic regression. RESULTS: 38 patients were recruited, and apnea achieved in 31 patients. The estimate of the ED80 was 0.184 µg/kg/min (95% CI 0.178-0.190). Post hoc analysis revealed that higher doses were required in younger patients. CONCLUSION: The ED80 for this indication was 0.184 µg/kg/min (95% CI 0.178-0.190). This is different from optimal dosing identified for other indications and dosing of remifentanil should be specific to the clinical context in which it is used.
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Apneia , Propofol , Anestesia Geral , Anestésicos Intravenosos , Apneia/induzido quimicamente , Teorema de Bayes , Criança , Pré-Escolar , Humanos , Lactente , Imageamento por Ressonância Magnética , Piperidinas , RemifentanilRESUMO
Despite difficulties in reading and writing, some research suggests that dyslexia may be related to higher levels of creativity. However, this pattern is not consistently observed. The current research sought to ascertain whether individuals with clinically diagnosed dyslexia exhibit higher creativity than controls through a meta-analysis. Fourteen studies that assessed the creativity of 397 individuals with clinically diagnosed dyslexia and 453 controls were reviewed. Random-effects meta-analysis revealed an overall non-significant difference in creativity scores between those with dyslexia and controls. Additionally, method factors such as the type of creativity task and whether intelligence was controlled for, as well as sample-related factors such as gender, did not explain differences in the dyslexia-creativity relationship. Nonetheless, individuals with dyslexia significantly outperformed controls in creativity scores in adult samples, but not in younger child/adolescent samples. Overall, the current findings provide limited support for the idea that individuals with dyslexia are more creative, and that past evidence of this relationship may be limited to adult samples.
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Criatividade , Dislexia/fisiopatologia , Leitura , Redação , Adolescente , Adulto , Criança , Feminino , Humanos , MasculinoRESUMO
OBJECTIVE: Research on subjective social status (SSS) and inflammation risk suffers from a lack of cross-cultural data as well as inconsistent findings between SSS and the biomarker C-reactive protein (CRP). The current study addressed these issues by examining possible cultural differences in the SSS-CRP link with anger control as an underlying mechanism while controlling for potential confounds such as wealth, education, and health factors. METHOD: Participants comprised 1,435 adults from the Biomarker Project of the MIDUS (American) and MIDJA (Japanese) studies. Participants' SSS and tendency to control anger were assessed through surveys, and their CRP levels were measured through fasting blood samples. RESULTS: Results showed that for Americans, CRP levels increased as SSS decreased, but for the Japanese, there was no relationship between SSS and CRP. Furthermore, this moderating effect of culture was mediated by anger control such that Americans controlled their anger less as SSS decreased, which then predicted higher levels of CRP, whereas the Japanese controlled their anger less as SSS increased, but this relationship did not predict CRP levels. These findings were specific to anger control (and not other varieties of anger) and robust to adjustment for a variety of potential confounds. CONCLUSIONS: Our findings demonstrate that culture exerts a moderating effect on the relationship between SSS and CRP, and this effect occurs through cultural differences in how SSS relates to anger control. The current study also highlights the need to consider cultural factors and psychosocial processes in further research on SSS and health. (PsycInfo Database Record (c) 2020 APA, all rights reserved).
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Ira/fisiologia , Proteína C-Reativa/metabolismo , Inflamação/epidemiologia , Distância Psicológica , Cultura , Feminino , Humanos , MasculinoRESUMO
This meta-analysis tested if the links between socioeconomic status (SES) and subjective well-being (SWB) differ by whether SES is assessed objectively or subjectively. The associations between measures of objective SES (i.e., income and educational attainment), subjective SES (i.e., the MacArthur ladder SES and perceived SES), and SWB (i.e., happiness and life satisfaction) were synthesized across 357 studies, totaling 2,352,095 participants. Overall, the objective SES and subjective SES measures were moderately associated (r = .32). The subjective SES-SWB association (r = .22) was larger than the objective SES-SWB association (r = .16). The income-SWB association (r = .23) was comparable with the ladder SES-SWB association (r = .22) but larger than the perceived SES-SWB association (r = .196). The education-SWB association (r = .12) was smaller than the associations with both measures of subjective SES. The subjective SES-SWB association was partially explained by common method variance. The subjective SES-SWB association, particularly with the ladder SES measure, also mediated the objective SES-SWB association. In moderation analyses, the objective SES-SWB associations strengthened as samples increased in wealth and population density. The subjective SES-SWB associations strengthened as samples increased in population density, decreased in income inequality, and decreased in relative social mobility. The role of common method variance, social comparisons, and other processes in explaining the SES-SWB links are discussed. (PsycInfo Database Record (c) 2020 APA, all rights reserved).
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Cultura , Felicidade , Qualidade de Vida/psicologia , Classe Social , Adulto , Escolaridade , Feminino , Objetivos , Humanos , Masculino , Pessoa de Meia-Idade , Fatores SocioeconômicosRESUMO
Identifying asymptomatic older individuals at elevated risk for developing Alzheimer disease (AD) is of clinical importance. Among 1,081 asymptomatic older adults, a recently validated polygenic hazard score (PHS) significantly predicted time to AD dementia and steeper longitudinal cognitive decline, even after controlling for APOE É4 carrier status. Older individuals in the highest PHS percentiles showed the highest AD incidence rates. PHS predicted longitudinal clinical decline among older individuals with moderate to high Consortium to Establish a Registry for Alzheimer's Disease (amyloid) and Braak (tau) scores at autopsy, even among APOE É4 noncarriers. Beyond APOE, PHS may help identify asymptomatic individuals at highest risk for developing Alzheimer neurodegeneration. Ann Neurol 2017;82:484-488.
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Doença de Alzheimer/genética , Apolipoproteína E4/genética , Predisposição Genética para Doença , Herança Multifatorial , Idoso , Idoso de 80 Anos ou mais , Progressão da Doença , Feminino , Genótipo , Humanos , Estudos Longitudinais , Masculino , Testes Neuropsicológicos , Medição de Risco , Fatores de RiscoRESUMO
By some accounts, global economic inequality is at its highest point on record. The pernicious effects of this broad societal trend are striking: Rising inequality is linked to poorer health and well-being across countries, continents, and cultures. The economic and psychological forces that perpetuate inequality continue to be studied, and in this theoretical review, we examine the role of daily experiences of economic inequality-the communication of social class signals between interaction partners-in this process. We theorize that social class signals activate social comparison processes that strengthen group boundaries between the haves and have nots in society. In particular, we argue that class signals are a frequent, rapid, and accurate component of person perception, and we provide new data and analyses demonstrating the accuracy of class signaling in 60-s interactions, Facebook photographs, and isolated recordings of brief speech. We suggest that barriers to the reduction of economic inequality in society arise directly from this class signaling process through the augmentation of class boundaries and the elicitation of beliefs and behaviors that favor the economic status quo.
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Disparidades nos Níveis de Saúde , Qualidade de Vida/psicologia , Classe Social , Fatores Socioeconômicos , HumanosRESUMO
The economic conditions of one's life can profoundly and systematically influence health outcomes over the life course. Our present research demonstrates that rejecting the notion that social class categories are biologically determined-a nonessentialist belief-buffers lower-class individuals from poor self-rated health and negative affect, whereas conceiving of social class categories as rooted in biology-an essentialist belief-does not. In Study 1, lower-class individuals self-reported poorer health than upper-class individuals when they endorsed essentialist beliefs but showed no such difference when they rejected such beliefs. Exposure to essentialist theories of social class also led lower-class individuals to report greater feelings of negative self-conscious emotions (Studies 2 and 3), and perceive poorer health (Study 3) than upper-class individuals, whereas exposure to nonessentialist theories did not lead to such differences. Discussion considers how lay theories of social class potentially shape long-term trajectories of health and affect of lower-class individuals.