RESUMO
Prophylactic treatment of mice with interferon (IFN) or polyinosinic-polycytidylic acid [poly(I:C)], an IFN inducer, provided significant protection against an extracellular infection by Aspergillus fumigatus in both Swiss and Swiss athymic nude mice. Tunicamycin (TM) treatment inhibits the antifungal activity of IFN and poly(I:C) in these mice. Anti-asialo GM1 or TM [both inhibitors of natural killer (NK) cell function] treatment enhance the severity of A. fumigatus infection. These results suggest that NK cells may play a role in A. fumigatus infection and in the antifungal activity of IFN.
Assuntos
Aspergilose/prevenção & controle , Gangliosídeo G(M1) , Interferons/uso terapêutico , Aspergillus fumigatus , Glicoesfingolipídeos/imunologia , Glicoesfingolipídeos/farmacologia , Interferons/antagonistas & inibidores , Rim/microbiologia , Células Matadoras Naturais/imunologia , Poli I-C/uso terapêutico , Tunicamicina/farmacologiaAssuntos
Antifúngicos/uso terapêutico , Candidíase/microbiologia , Úlcera da Córnea/microbiologia , Animais , Candida/efeitos dos fármacos , Candidíase/tratamento farmacológico , Úlcera da Córnea/tratamento farmacológico , Feminino , Humanos , Testes de Sensibilidade Microbiana , Pessoa de Meia-Idade , CoelhosAssuntos
Fibrilação Atrial/etiologia , Hepatite Viral Humana/complicações , Adulto , Humanos , MasculinoAssuntos
Anfotericina B/farmacologia , Fusarium/efeitos dos fármacos , Ceratite/tratamento farmacológico , Fungos Mitospóricos/efeitos dos fármacos , Rhizoctonia/efeitos dos fármacos , Anfotericina B/uso terapêutico , Animais , Córnea/efeitos dos fármacos , Córnea/enzimologia , Peptídeo Hidrolases/metabolismo , Monoéster Fosfórico Hidrolases/metabolismo , CoelhosRESUMO
Life-table analysis consecutive cases of isolated coronary bypass surgery at the Buffalo Hospital between 1973 and 1977 showed an estimated survival of 94 per cent at five years, equal to that of an age- and sex-matched group of the US population. Subsets of these patients divided according to sex, age, number of vessels narrowed, number of segments grafted, history of myocardial infarction, ejection fraction, and presence of unstable angina have estimated survivals not statistically less in any of these subsets than that of matched cohorts of the general population.