1.
Bioorg Med Chem Lett
; 26(17): 4250-5, 2016 09 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-27476420
RESUMO
IRAK4 has been identified as potential therapeutic target for inflammatory and autoimmune diseases. Herein we report the identification and initial SAR studies of a new class of pyrazole containing IRAK4 inhibitors designed to expand chemical diversity and improve off target activity of a previously identified series. These compounds maintain potent IRAK4 activity and desirable ligand efficiency. Rat clearance and a variety of off target activities were also examined, resulting in encouraging data with tractable SAR.