RESUMO
Photodegradation, a widely accepted and promising technology, has gained significant attention for addressing the escalating concerns of environmental deterioration. In this article, rhombohedral corundum-type In2O3 nanocrystals were obtained from the transformation of InOOH via a simple calcining process. Under ultraviolet light irradiation, they showed higher photocatalytic activity in the decomposition of rifampin compared to that of the cubic phase In2O3 and P25-TiO2. Furthermore, the probable pathway and the feasible mechanism for the degradation of rifampin were also deeply explored and discussed.
RESUMO
InOOH bulk crystals and ultrathin nanowires have been investigated under high pressures by in situ synchrotron radiation X-ray diffraction measurements at ambient temperature. The anisotropic compression indicates that the b-axis is more compressible than the other two axes in InOOH under hydrostatic conditions. Two inflection points, which are associated with the hydrogen-bond strengthening, can be reflected in the plots of b/c ratio versus pressure (b/c-P plots). The size-induced enhancement of the bulk modulus can be visualized from the P-V plots. By comparing the differences in the compression of bulk InOOH and ultrathin nanowires, it is validated that the nanosize effects play an important role in the high-pressure behaviors of InOOH.
RESUMO
The objective of this study is to use a carbohydrate polymer hyaluronic acid (HLA) as matrix to design novel transdermal nanogel loading poorly soluble drug nanocrystals. Baicalin nanocrystals (BCA-NC) were prepared by coupling homogenization technology and spray-drying technology. The morphology, the rheological behavior and transdermal permeation studies of HLA based BCA-NC-gel were evaluated. The results demonstrated that the BCA-NC could be successfully prepared in terms of trehalose after spray-drying. The trehalose could prevent the aggregation of BCA-NC during spray-drying. It was discovered that, the BCA-NC-gel with 1% HLA possessed the favorable gelatin capacity and thinning shear rheological property. In vitro transdermal permeation studies of BCA-NC-gel/HLA studies indicated a marked increase in the skin permeation of BCA. And the transdermal flux of BCA-NC-gel with 1% HLA were 20.65-fold higher (p < 0.01) than that of coarse BCA-gel, which could be attributed to particles size reduction of BCA-NC and bioadhesive property of HLA. And the morphology characterization of BCA-NC-gel/HLA demonstrated that BCA-NC could be imprisoned into the gel network of HLA, which might prevent it from aggregation in gel. In conclusion, HLA based nanogel system is a promising carrier for effectively transdermal delivery of poorly soluble drug.
