RESUMO
Alcoholism and depression have always been in intricated. A lot of studies try presently to precise this relation:--Clinical studies about episodic alcoholism.--Genetical studies showing a debatable relation between alcoholism and unipolar depression.--Biological studies essentialy attesting a depressive action of ethanol among the serotoninergic system: ethanol would deviate the serotonin metabolism. Likewise it would induce a depletion of catecholamines in the brain. More, biochemical researches point out an inheritance of ethanol preference which would be correlated with a decrease of the brain level of serotonin. Is is a genetical transmission of alcoholism: these perturbations could manifest themselves by the ethanol dependence, or by depressive trends?
Assuntos
Alcoolismo/complicações , Depressão/complicações , Alcoolismo/genética , Alcoolismo/metabolismo , Animais , Antidepressivos/farmacologia , Química Encefálica , Catecolaminas/fisiologia , Depressão/genética , Depressão/metabolismo , Humanos , Serotonina/fisiologiaRESUMO
Twenty cases of thalassemia major and 20 children with glucose-6-phosphate dehydrogenase deficiency were studied for the protein content of their red cell membrane as well as for its fractions, compared to 20 normal controls. The results showed that the total membrane proteins per red cell and the various fraction percentages in both conditions were not significantly different from normal controls. Also the acrylamide gel electrophoretic studies of the red cell membrane proteins gave band patterns identical with those of normal controls. These results are discussed.