Radiofrequency Ablation Is Low Invasive and Effective in Treat Pleomorphic Adenoma in Trachea Without Recurrence for At Least Five Years.

The authors reported 6 patients of pleomophic adenoma in trachea in patients (57 ±â€Š3.6 years old). Swellings in trachea (2 ±â€Š0.85 cm) were revealed by computed tomography and bronchoscopy. All swellings were removed successfully using radiofrequency ablation through flexible bronchoscopy. Histopathological examinations of tumor specimens confirmed their diagnosis of pleomorphic adenoma. No complication nor tumor recurrences were reported throughout the 5-year postoperative follow-up period in each patient which indicate good prognosis. The authors here report an effect but mini-invasive approach to treat rare trachea tumor and demonstrate a way of successful treatment using a mini-invasive way. Compared with other treating procedures, the authors consider radiofrequency ablation is of low invasion with the consequence of cure all treated patients of pleomorphic adenoma in trachea.

Nitric oxide induces apoptosis of the hair cells of cochlea.

OBJECTIVE: Nitric oxide (NO) has a toxic effect on neuronal cells related to glutamate receptors. NO released from post-synaptic cells with glutamate receptors can induce nearby cell death. In this experiment, we examined the effect of NO on cochlear hair cells. METHODS: Two concentrations, 0.5 and 0.1 molar concentration (MC) of 1-hydroxy-2-oxo-3-(3-aminopropyl)-3-isopropyl-1-triazene (NOC-5), which is a NO donor, were placed on the round window of the guinea pig cochlea and its morphological changes were investigated at 12, 28, 72 h after the treatment. RESULTS: By the trypan blue dye extrusion method, the cell death was recognized in the outer hair cells at the percentage 0, 36.0+/-6.6, 4.9+/-1.2% at 12, 28, 72 h after treatment respectively in the group 0.5 MC NOC-5, but no inner hair cell death was recognized. In the group of 0.1 MC NOC-5 and control any cell death was not detected. Transmission electron microscopy revealed this cell death was characteristic of apoptosis. CONCLUSION: The findings that apoptosis was induced in the outer hair cells of the organ of Corti by NO suggests the possibility that the cochlea is affected when extra NO release occurs there, leading to cochlear dysfunction.