1.
Lung
; 195(4): 517-521, 2017 08.
Artigo
em Inglês
| MEDLINE
| ID: mdl-28551717
RESUMO
The cellular immune response to Mycobacterium tuberculosis infection has been well characterized, while the humoral antibody response remains underexplored. We aimed to examine the total and anti-phospholipid IgM levels in the pleural lavage from mice with Mycobacterium bovis BCG extrapulmonary infection. We found that the levels of total and anti-phosphatidylcholine IgM antibodies remained significantly higher in infected mice as compared to non-infected mice up to day 90 after BCG infection, while the anti-cardiolipin IgM antibody levels decreased with bacteria clearance. Our findings suggest that IgM antibodies are secreted and their composition vary during early and late immune response to BCG pleurisy.
Assuntos
Anticorpos Antifosfolipídeos/imunologia , Imunidade Humoral , Imunoglobulina M/imunologia , Mycobacterium tuberculosis/imunologia , Fosfatidilcolinas/imunologia , Tuberculose Pleural/imunologia , Animais , Anticorpos Anticardiolipina/imunologia , Carga Bacteriana , Modelos Animais de Doenças , Feminino , Interações Hospedeiro-Patógeno , Masculino , Camundongos Endogâmicos C57BL , Fatores de Tempo , Tuberculose Pleural/microbiologia
2.
La Paz; OPS/OMS; dic.2009. s p.
Não convencional
em Espanhol
| LIBOCS, LIBOSP
| ID: biblio-1301825