Humoral Immune Response of BNT162b2 and CoronaVac Vaccinations in Hemodialysis Patients: A Multicenter Prospective Cohort.

The CoronaVac vaccine is the most used anti-SARS-CoV-2 vaccine worldwide. Previous data indicate that this vaccine produces a lower immune response than RNA vaccines such as BNT162b2. End-stage renal disease (ESRD) patients have an increased rate of COVID-19 and a reduced immune response to vaccinations. Currently, there is little data on this population's immune response induced by CoronaVac. Methods: This study involved a prospective cohort of ESRD patients in chronic hemodialysis who received a two-dose immunization scheme of either CoronaVac (Sinovac Biotech) or BNT162b2 vaccines (Pfizer-BioNTech). We measured the plasma levels of anti-SARS-CoV-2 IgG antibodies. We determined antibody titers before immunization, 2 and 4 months after two doses, plus 4 months after a booster dose. Results: We evaluated 208 patients in three hemodialysis centers. The mean age was 62.6 ± 15.6 years, of whom 91 were female (41.75%). Eighty-one patients (38.94%) received the BNT162b2 vaccine and 127 (61.06%) received the CoronaVac vaccine. Patients who received the BNT162b2 vaccine had a higher humoral response compared to those who received the CoronaVac vaccine (4 months after the second dose: BNT162b2: 88.89%, CoronaVac: 51.97%, p < 0.001; 4 months after the booster: BNT162b2: 98.77%, CoronaVac: 86.61%, p < 0.001). Conclusions: Our results suggest that the CoronaVac vaccine induced a lower humoral response than the BNT162b2 vaccine in ESRD patients on hemodialysis.

Seed predation and potential seed dispersers of the narrow endemic Ceratozamianorstogii (Zamiaceae).

In this study, we report the observation of potential seed dispersers of the endemic to Mexico and narrowly distributed Ceratozamianorstogii (Zamiaceae). Camera traps were installed in front of two plants of Ceratozamianorstogii and cone phenology until their maturity and disintegration was determined. The female cone of Ceratozamianorstogii has a development of ten months, from the time it emerges until it disintegrates. We were able to identify three stages of cone development: 1) Pre-pollination phase, 2) Pollination phase and 3) Seed maturation phase. Our results support an animal-dispersal hypothesis in Ceratozamia. Three mammals [a mouse (Pteromiscus sp.), a southern spotted skunk (Spilogaleangustifrons) and a kinkajou (Potusflavus)] were recorded biting, carrying or removing seeds of Ceratozamianorstogii. The camera traps recorded no evidence of birds or other mammals coming to the cones to feed. Thus, interaction of frugivores with seeds occurs at night. The most frequent visitor was the mouse, followed by the southern spotted skunk and the kinkajou. Significant differences (GLM, p< 0.05) in visitor frequency and time for interaction were found between species. We believe that the mouse is probably the most effective seed disperser for Ceratozamianorstogii. The results presented here have evolutionary implications that can be scaled to the entire genus Ceratozamia. Specifically, short-distance dispersal promotes allopatric speciation in this group of plants.

Learning to Work with Trauma Survivors: Lessons from Tbilisi, Georgia.

Survivors of armed conflict may experience traumatic stress, psychological symptoms, distress, or other behavioral health issues related to the disaster of war. This article outlines the historical background of the Russian-Georgian war, details the implementation of social work in the developing country of Georgia, and describes the training and application of social work knowledge and values using macro and micro examples of interventions that provide Masters of social work students and social workers with tools to address the needs of refugees affected by disaster. Following the macro- and microexamples, pedagogy and implications for social workers and social work students working with victims of trauma with few available resources are discussed.