RESUMO
Oligodendroglia growth factor (OGF) is a 16-kDa soluble protein produced by neuronal cell lines. This factor, when incubated with brain glia in culture, selectively stimulates growth of oligodendroglia, the myelin-producing cells of the CNS. OGF infused into the cerebral cortex of the adult rat accelerates the production of myelin proteins as shown by increased specific activity of the myelin enzyme 2',3'-cyclic nucleotide 3'-phosphohydrolase (2',3'-CNPase), by stimulated synthesis of myelin basic protein, and by elevations in levels of myelin proteolipid protein RNA. The ability of OGF to induce myelin protein production in vivo suggests that neuron-secreted growth factors help to regulate myelin formation within the CNS.
Assuntos
Encéfalo/metabolismo , Proteínas da Mielina/biossíntese , Proteínas do Tecido Nervoso/farmacologia , Neurônios/metabolismo , Animais , Linhagem Celular , Fenômenos Químicos , Química , Fator de Maturação da Glia , Proteína Básica da Mielina/biossíntese , Proteínas da Mielina/metabolismo , Proteína Proteolipídica de Mielina , Proteínas do Tecido Nervoso/isolamento & purificação , Proteínas do Tecido Nervoso/metabolismo , RatosRESUMO
There is growing evidence that immunomodulators influence cellular events within the central nervous system. Microglia are one important class of effector cells in the brain which both respond to and secrete immunoregulatory factors. By controlling the proliferation, death, or differentiation of neighboring cells, microglia may regulate the structure and function of neural tissues during development and in response to injury. As described here, suppression of microglia offers a new approach in the treatment of neurologic diseases.