RESUMO
In the present study, in situ hybridization was used to examine the expression of nerve growth factor (NGF) receptor (p75NGFR), trk (p140trk) and trkB (p145trkB) mRNA in spinal cord sections from patients with amyotrophic lateral sclerosis (ALS). We report that the expression of p75NGFR and p145trkB mRNA is elevated in alpha motoneurons in ALS sections. However, p140trk mRNA was not expressed in either ALS or control sections.
Assuntos
Esclerose Lateral Amiotrófica/metabolismo , Neurônios Motores/metabolismo , Proteínas Proto-Oncogênicas/genética , RNA Mensageiro/biossíntese , Receptores Proteína Tirosina Quinases/genética , Receptores de Fator de Crescimento Neural/genética , Medula Espinal/metabolismo , Adulto , Humanos , Pessoa de Meia-Idade , Receptor trkA , Medula Espinal/citologiaAssuntos
Vértebras Cervicais , Deslocamento do Disco Intervertebral/complicações , Paralisia/etiologia , Sensação , Compressão da Medula Espinal/etiologia , Adulto , Feminino , Humanos , Imageamento por Ressonância Magnética , Masculino , Pessoa de Meia-Idade , Doenças do Sistema Nervoso/etiologia , Compressão da Medula Espinal/diagnóstico , SíndromeRESUMO
A rare case of homozygous protein C deficiency occurred in a newborn. The patient presented with purpura fulminans in the first few hours after birth and showed multiple hemorrhagic lesions on computed tomography of the brain at 5 days of age. Neurologic symptoms developed at two weeks and the patient died at 37 weeks. His protein C level was less than 5%. Autopsy revealed thrombosis of the dural sinuses, multiple cortical infarcts, intraparenchymal hemorrhages, and hydrocephalus. The pathologic findings are correlated with the neurologic deficits and previously documented cases are reviewed.
Assuntos
Encéfalo/patologia , Proteína C/análise , Transtornos da Coagulação Sanguínea/congênito , Transtornos da Coagulação Sanguínea/etiologia , Transtornos da Coagulação Sanguínea/genética , Hemorragia Cerebral/patologia , Homozigoto , Humanos , Hidrocefalia/etiologia , Hidrocefalia/patologia , Recém-Nascido , Masculino , Proteína C/genética , Trombose dos Seios Intracranianos/patologia , Trombose/etiologia , Trombose/genética , Trombose/patologiaRESUMO
To examine animal exposure in ALS patients, a case-control study was undertaken on 40 ALS patients and 40 closely matched controls. Exposure to pets of any kind and to small dogs in the period from birth until 10 years before onset of ALS symptoms was significantly increased. Affected men showed a trend toward increased exposure to neurologically ill pets, but there was no significant difference when male and female cases were grouped. No differences between ALS cases and controls were observed in exposure to any other single animal species. There may be a link between ALS and exposure to house pets.
