Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 11 de 11
Filtrar
1.
Eur Rev Med Pharmacol Sci ; 18(19): 2846-50, 2014 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-25339478

RESUMO

Normal healing of fractures is a complex process that relies heavily on a cascade of consecutive activations of immune cells and mediators. This mechanism somewhat overlaps with all processes related to bone metabolism, from the absence of unions to heterotopic ossifications and osteoporosis. We aimed to review and describe this intricate process of bone metabolism with particular focus on abnormal function and to exemplify it with a series of clinical cases which could justify their practical importance. The elbow has great potential for fracture healing but it is very sensitive to prolonged immobilization which can easily lead to intra-articular adherences and stiffness. In addition, the interosseus membrane facilitates communication between the regenerative environments when both radius and ulna are fractured. Such extensive injuries, around the proximal forearm, can lead to heterotopic ossifications and synostosis, which decrease sagittal range of motion through impingement and even block rotational movement through bone bridges. Increased knowledge and awareness of the biological mechanism of fracture healing, will have great improvement in the pharmacological adjuvant treatment of elbow injuries.


Assuntos
Lesões no Cotovelo , Cotovelo/fisiologia , Consolidação da Fratura/fisiologia , Fraturas Ósseas/imunologia , Fraturas Ósseas/patologia , Animais , Cotovelo/patologia , Humanos , Osteoporose/imunologia , Osteoporose/patologia , Amplitude de Movimento Articular/fisiologia
2.
Eur Rev Med Pharmacol Sci ; 18(11): 1638-46, 2014 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-24943975

RESUMO

OBJECTIVE: Besides than in the control of developmental events, axonal adhesive glycoproteins may be also involved in functions requiring fine organization and connectivity of the nervous tissue. We previously demonstrated morphological alterations and functional cerebellar deficits in transgenic mice (TAG/F3 mice) ectopically expressing the F3/Contactin axonal glycoprotein under the control of a selected regulatory region from the Transient Axonal Glycoprotein (TAG-1) gene. In the present study, the hippocampal function was explored by evaluating the ability of TAG/F3 mice to encode spatial and non-spatial relationships between discrete stimuli and to analyze an anxiety-related behavior. MATERIALS AND METHODS: To the first end, mice were placed in an "open-Field" containing five objects and, after three sessions of habituation (S2-S4), their reactivity to objects displacement (S5-S4) and object substitution (S7-S6) was examined.To the second end, mice were placed in the "elevated zero maze", a standard test to explore the anxiety-related behavior, in order to study, in transgenic mice, the effects of F3 misexpression on emotional reactivity by measuring the avoidance of the unsheltered open sectors. RESULTS: Statistical evaluations of reactivity to object novelty, TAG-F3 mice showed a lower DO exploration with respect to wild-type mice and, regarding DOs, TAG/F3 mice interacted less than wild-type mice, showing an impaired spatial change response. Furthermore, the number of HDIPS in transgenic TAG/F3 mice resulted significantly lower with respect to the controls (wild type). CONCLUSIONS: These results indicate that the coordinated expression of axonal adhesive glycoproteins may be relevant for the functional maturation of the hippocampus.


Assuntos
Comportamento Animal/fisiologia , Contactina 1/fisiologia , Animais , Ansiedade/genética , Ansiedade/psicologia , Axônios/fisiologia , Contactina 1/genética , Feminino , Hipocampo/crescimento & desenvolvimento , Hipocampo/fisiologia , Masculino , Aprendizagem em Labirinto/fisiologia , Camundongos , Camundongos Endogâmicos C57BL , Camundongos Endogâmicos CBA , Camundongos Transgênicos , Atividade Motora/fisiologia , Gravidez
3.
Eur Rev Med Pharmacol Sci ; 18(24): 3898-901, 2014.
Artigo em Inglês | MEDLINE | ID: mdl-25555881

RESUMO

OBJECTIVE: Muscle-skeletal tumors represent a challenging pathology for orthopedic surgeons worldwide. The extremely invasive character, the local destruction, the high recurrence rate, the high incidence in young patients and the unfavorable prognosis are all very well known. For these patients it is very important to produce an accelerated functional, social and psychological postoperative rehabilitation. We studied 121 cases of muscle-skeletal tumors which were treated in our hospital over a 5 years period. PATIENTS AND METHODS: We noticed a high prevalence in males and mainly between the 2nd-3rd and 5th-7th decades of their life. At our observation, most patients were suffering in advanced stages of malignant lesions. RESULTS: We try to manage amputations below 5%, with a significant reduction in introducing reconstructive surgical methods as a choice of treatment (10 prostheses and 12 cases of filling with acrylic cement or bone substituent increased with internal fixation). In this way we could observe an unusual ratio between benign and malignant tumors, probably caused by the patient's lack of concern for minimal symptoms. The rural citizen's addressability towards the medical system is alarmingly low, due to the big gap existing from diagnosis to treatment. CONCLUSIONS: There is still an hard effort to develop better reconstructive techniques for the treatment of muscle-skeletal tumors and more studies must be made in order to achieve this goal.


Assuntos
Neoplasias Ósseas/cirurgia , Neoplasias Musculares/cirurgia , Adulto , Fatores Etários , Idoso , Neoplasias Ósseas/epidemiologia , Neoplasias Ósseas/patologia , Gerenciamento Clínico , Feminino , Humanos , Incidência , Masculino , Pessoa de Meia-Idade , Neoplasias Musculares/epidemiologia , Neoplasias Musculares/patologia , Estadiamento de Neoplasias , Prevalência , Prognóstico , Estudos Retrospectivos , Romênia/epidemiologia
4.
Eur Rev Med Pharmacol Sci ; 17(15): 2085-90, 2013.
Artigo em Inglês | MEDLINE | ID: mdl-23884830

RESUMO

BACKGROUND: While antioxidants and probiotics have been proposed for the treatment of functional dyspepsia, current data are still heterogeneous and studies are poorly designed. Extra-virgin olive oil, a common ingredient of Mediterranean diet, has shown antioxidant properties. AIMS: To evaluate the effect of extra-virgin olive oil enriched with antioxidants or probiotics on functional dyspepsia. PATIENTS AND METHODS: This study has been designed as a "proof of concept". Extra-virgin olive oil enriched with antioxidants or probiotics was blindly added to the common diet of 8 subjects with functional dyspepsia for 7 days. Dyspeptic symptoms were then evaluated in all patients. RESULTS AND CONCLUSIONS: A significant improvement of dyspeptic symptoms was observed in subjects receiving the antioxidant or probiotic enriched oil diet, with a greater effect observed for the latter. Larger studies are now needed to confirm these data.


Assuntos
Antioxidantes/uso terapêutico , Dispepsia/dietoterapia , Óleos de Plantas/uso terapêutico , Probióticos/uso terapêutico , Carotenoides/uso terapêutico , Dieta , Gorduras Insaturadas na Dieta/uso terapêutico , Humanos , Limosilactobacillus reuteri , Lacticaseibacillus rhamnosus , Licopeno , Azeite de Oliva , Projetos Piloto , Resveratrol , Saccharomyces , Selênio/uso terapêutico , Estilbenos/uso terapêutico , Ubiquinona/análogos & derivados , Ubiquinona/uso terapêutico
5.
Eur Rev Med Pharmacol Sci ; 16(9): 1222-6, 2012 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-23047506

RESUMO

OBJECTIVES: Aim of this work is to show the effectiveness of a protocol involving the use of platelet-rich plasma (PRP) as a grafting material in bone regeneration before dental implant rehabilitation. MATERIALS AND METHODS: 127 patients, requiring maxillary sinus lift, were enrolled in a follow-up study plan, which established clinical and radiological examinations on the day after surgery and six months later. PRP, in combination with autogenous bone, an organic bone material and organic bone substitutes, was used before implant-prosthetic rehabilitation. RESULTS AND CONCLUSIONS: After implant placement, 63 patients, previously treated with PRP, reached a statistically significant improvement in implant-prosthetic rehabilitation, established by primary stability and radiographic integration criteria, in comparison with the other 64 patients receiving implant-prosthetic rehabilitation without PRP treatment.


Assuntos
Regeneração Óssea , Implantação Dentária Endóssea , Seio Maxilar/cirurgia , Procedimentos Cirúrgicos Pré-Protéticos Bucais/métodos , Plasma Rico em Plaquetas , Cicatrização , Adulto , Feminino , Humanos , Masculino , Pessoa de Meia-Idade
6.
Ultrasound Obstet Gynecol ; 40(3): 304-9, 2012 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-22351034

RESUMO

OBJECTIVES: The purpose of this study was to investigate early markers of risk for neurobehavioral compromise in survivors with congenital heart disease (CHD). METHODS: Pregnant women in whom a fetal CHD had been diagnosed before 24 weeks' gestational age (GA) were enrolled in this prospective pilot study for serial Doppler ultrasound assessment of the fetal middle cerebral artery (MCA) and umbilical arteries. The cerebral-to-placental resistance ratio (CPR) and MCA pulsatility index (PI) Z-scores for GA were calculated. After birth, subjects underwent high-density (128-lead) electroencephalography (EEG), and beta frequency (12-24 Hz) band EEG power, a measure of local neural synchrony, was analyzed. Neurodevelopment was assessed at 18 months with the Bayley Scales of Infant Development (BSID)-III. RESULTS: Thirteen subjects were enrolled: four with hypoplastic left heart syndrome (HLHS), four with transposition of the great arteries (TGA) and five with tetralogy of Fallot (TOF). Compared with subjects with normal CPR, those with CPR < 1 (n = 7) had lower mean BSID cognitive scores (91.4 ± 4.8 vs. 99.2 ± 3.8, P = 0.008). Fetal MCA-PI Z-score also correlated with BSID cognitive score (r = 0.589, P = 0.03) as did neonatal EEG left frontal polar (r = 0.58, P = 0.037) and left frontal (r = 0.77, P = 0.002) beta power. Furthermore, fetal Doppler measures were associated with EEG power: fetuses with CPR < 1 had lower left frontal polar (t = 2.36, P = 0.038) and left frontal (t = 2.85, P = 0.016) beta power as newborns than did fetuses with normal CPR, and fetal MCA-PI Z-score correlated with neonatal EEG left frontal polar (r = 0.596, P = 0.04) and left frontal (r = 0.598, P = 0.04) beta power. CONCLUSION: In fetuses with HLHS, TGA and TOF, abnormal cerebrovascular resistance predicts decreased neonatal EEG left frontal beta power and lower 18-month cognitive development scores.


Assuntos
Sistema Nervoso Central/crescimento & desenvolvimento , Circulação Cerebrovascular/fisiologia , Eletroencefalografia/métodos , Cardiopatias Congênitas/diagnóstico por imagem , Artéria Cerebral Média/diagnóstico por imagem , Ultrassonografia Doppler/métodos , Ultrassonografia Pré-Natal/métodos , Artérias Umbilicais/diagnóstico por imagem , Sistema Nervoso Central/fisiopatologia , Feminino , Feto , Humanos , Recém-Nascido , Masculino , Projetos Piloto , Gravidez , Estudos Prospectivos
7.
Eur Rev Med Pharmacol Sci ; 15(11): 1296-300, 2011 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-22195362

RESUMO

OBJECTIVE: Aim of the present work is to assess the effectiveness of a scientific protocol built up to relieve pain in chronic temporo-mandibular disorders (TMD) using Michigan splint together with a pharmacological therapy compared to the traditional occlusal therapy by Michigan splint alone. PATIENTS: 35 adult patients, with signs and symptoms of TMD lasting more than 6 months, were enrolled into this study and divided into two groups: the first receiving occlusal therapy by Michigan splint and pharmacological therapy with Delorazepam and Thiocolchicoside, while the second receiving occlusal therapy by Michigan splint and "placebo" administration. The comparisons between the two experimental groups were assessed using a 5 steps visual-analogue scale (V.A.S.). RESULTS AND CONCLUSIONS: The outcomes from the experimental groups were statistically compared resulting significantly different with an improvement or disappearance of signs and symptoms in the treated group with respect to the placebo group at 12 and 18 months from the beginning of the experiment (p < 0.001).


Assuntos
Placas Oclusais , Transtornos da Articulação Temporomandibular/tratamento farmacológico , Transtornos da Articulação Temporomandibular/terapia , Adulto , Benzodiazepinas/uso terapêutico , Doença Crônica , Colchicina/análogos & derivados , Colchicina/uso terapêutico , Terapia Combinada , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Relaxantes Musculares Centrais/uso terapêutico , Nordazepam/análogos & derivados , Nordazepam/uso terapêutico , Dor/tratamento farmacológico , Dor/etiologia , Medição da Dor/efeitos dos fármacos , Resultado do Tratamento
8.
Eur Rev Med Pharmacol Sci ; 14(6): 507-12, 2010 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-20712257

RESUMO

Rats receiving fluoride during the whole pregnancy up to the 9th day of lactation showed, when isolated at 10th day of life, a reduced rate of ultrasonic vocalizations (UV) in male pups (NaF 5.0 mg) and, in 90th days male rats, an increase of the Pre-Pulse Inhibition (PPI) with a reduction of the Peak response to the Startle stimulus given alone. Newborn rat reactivity could represent a useful and validated model in anxiety studies which could be moored with the Acoustic Startle Reflex (ASR) and PPI, appropriate models to study, in adulthood, particular neurological and psychiatric disorders showing deficits in attention and sensory-motor gating (Tourettes' syndrome, obsessive compulsive disorders, Huntington's disease and schizophrenia).


Assuntos
Feto/efeitos dos fármacos , Reflexo Acústico/efeitos dos fármacos , Reflexo de Sobressalto/efeitos dos fármacos , Fluoreto de Sódio/toxicidade , Vocalização Animal/efeitos dos fármacos , Animais , Feminino , Masculino , Gravidez , Ratos , Ratos Wistar , Reflexo Acústico/fisiologia , Reflexo de Sobressalto/fisiologia
9.
Eur Rev Med Pharmacol Sci ; 11(4): 211-24, 2007.
Artigo em Inglês | MEDLINE | ID: mdl-17876956

RESUMO

Contrasting studies on the toxic effects of sodium fluoride (NaF) during developmental stages of Wistar rats, lead us to investigate the neurofunctional effects caused by its perinatal exposure, devoid of any overt sign of toxicity and/or gross malformation. NaF solution was administered to pregnant rats by intragastric gavage at a daily dose of 2.5 and 5.0 mg/kg from gestational day 0 to day 9 after parturition. Developmental NaF exposure caused sex and dose specific behavioural deficits which affected males more than females in the majority of the evaluated end-points. In particular, the perinatal exposure to NaF 5.0 mg/kg, significantly affected learning, memory, motor coordination and blood pressure only in male rats. Conversely, a lack of habituation upon the second presentation of the objects and failure in the ability to discriminate between the novel and the familiar object were observed only in NaF 5.0 mg/kg female rats. Finally, a significant impairment of sexual behaviour was observed in male rats at both NaF dose levels. The present data indicate that perinatal rat exposure to NaF results in long lasting functional sex-specific alterations which occur at fluoride levels approaching those experienced by offspring of mothers.


Assuntos
Comportamento Animal/efeitos dos fármacos , Cariostáticos/toxicidade , Efeitos Tardios da Exposição Pré-Natal , Fluoreto de Sódio/toxicidade , Animais , Aprendizagem da Esquiva/efeitos dos fármacos , Pressão Sanguínea/efeitos dos fármacos , Relação Dose-Resposta a Droga , Comportamento Exploratório/efeitos dos fármacos , Feminino , Idade Gestacional , Habituação Psicofisiológica/efeitos dos fármacos , Masculino , Memória/efeitos dos fármacos , Gravidez , Desempenho Psicomotor/efeitos dos fármacos , Ratos , Ratos Wistar , Medição de Risco , Fatores Sexuais , Comportamento Sexual Animal/efeitos dos fármacos , Fatores de Tempo , Vocalização Animal/efeitos dos fármacos
10.
Neuroscience ; 135(3): 897-905, 2005.
Artigo em Inglês | MEDLINE | ID: mdl-16112480

RESUMO

Glutamic acid decarboxylase and GABA immunoreactivities were qualitatively and quantitatively evaluated in the cerebellar cortex of adult rats prenatally exposed to a low concentration of carbon monoxide (75 parts per million). Carbon monoxide-exposed and control rats were perfused with modified Bouin's fluid and their cerebella were embedded in paraffin. Sections from the vermis of each cerebellum were stained with Toluidine Blue or assayed with anti-glutamic acid decarboxylase 65/67 or with anti-GABA antisera. In the Toluidine Blue-stained sections, no differences were observed in the microscopic structure of the cerebellar cortex between carbon monoxide-exposed rats and controls. The distribution patterns of glutamic acid decarboxylase and GABA immunoreactivities in the cerebellar cortex of the treated animals were qualitatively comparable to those of the controls, and in accordance with previous descriptions of glutamic acid decarboxylase and GABA immunoreactivities in the rat cerebellar cortex. However, quantitative analyses demonstrated a significant reduction of immunoreactivities to both substances in the exposed rats in comparison with the controls. The reduction regarded: in the molecular layer, the number of glutamic acid decarboxylase/GABA-immunoreactive neuronal bodies and of axon terminals and the area they covered; in the Purkinje neuron layer, the number and the area covered by glutamic acid decarboxylase/GABA immunoreactive axon terminals. The differences detected in the prenatally exposed adult rats could be due to carbon monoxide-induced impairment of the differentiation of cerebellar GABA synthesizing neurons. A consequently diminished synthesis of GABA might account for some behavioral disorders detected in adult rats submitted to the same experimental procedure.


Assuntos
Monóxido de Carbono/toxicidade , Córtex Cerebelar/metabolismo , Glutamato Descarboxilase/metabolismo , Efeitos Tardios da Exposição Pré-Natal , Ácido gama-Aminobutírico/metabolismo , Animais , Carboxihemoglobina/metabolismo , Córtex Cerebelar/enzimologia , Corantes , Grânulos Citoplasmáticos/enzimologia , Grânulos Citoplasmáticos/metabolismo , Feminino , Imuno-Histoquímica , Masculino , Gravidez , Células de Purkinje/enzimologia , Células de Purkinje/metabolismo , Ratos , Ratos Wistar , Fumar/metabolismo , Cloreto de Tolônio
11.
Eur Rev Med Pharmacol Sci ; 5(4): 127-9, 2001.
Artigo em Inglês | MEDLINE | ID: mdl-12067080

RESUMO

The sensitivity of H. Pylori to antibiotic treatment is well known. Politherapy (omeprazole or pantoprazole or ranitidine, amoxicillin and/or azithromycin and/or clarithromycin, metronidazole and bismuth citrate) notably changed the percentage of H. pylori eradication but rarely resolutive. Periodontal pockets treatment with topic metronidazole, calcium sulphate and potassium sulphate resulted active against bacteria included in periodontal pockets leading to a long-term H. pylori eradication (two years follow-up).


Assuntos
Sulfato de Cálcio/uso terapêutico , Infecções por Helicobacter/tratamento farmacológico , Helicobacter pylori , Metronidazol/uso terapêutico , Bolsa Periodontal/tratamento farmacológico , Quimioterapia Combinada , Infecções por Helicobacter/microbiologia , Humanos , Bolsa Periodontal/microbiologia , Projetos Piloto , Prevenção Secundária
SELEÇÃO DE REFERÊNCIAS
DETALHE DA PESQUISA