[Assessment of the erythropoietin-producing function of the kidney and liver under controlled perfusion]. / Otsenka éritropoétinprodutsiruiushchei funktsii pochki i pecheni v usloviiakh upravliaemoi perfuzii.

The balance of erythropoietin production by the dog kidney and liver was studied during controlled normoxic perfusion. The hormone production was stimulated by acute posthemorrhagic anemia (bloodletting of 25% total blood volume) combined with subcutaneous injection of cobaltous chloride (250 microM/kg body weight). The increase in erythropoietin level was revealed in posthypoxic animal perfusate after 6 hours of perfusion. The amount of hepatic erythropoietin was shown to be 2.5 times higher than that excreted by kidneys.